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Paper · 47889

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

Nossal GJ and 1 other. J Exp Med, 1975. Cited by 291 papers, by iCite.

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ConductScience Library. Evidence for the clonal abortion theory of B-lymphocyte tolerance. Papers, record 47889. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/47889

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Evidence for the clonal abortion theory of B-lymphocyte tolerance.
PubMed
Journal
J Exp Med
PubMed
Year
1975
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
291
iCite
Relative citation ratio, by iCite
5.19
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Nossal GJG J
2Pike BLB L

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Immune ToleranceMajor topic
Animals
Antigens
Birds
Bone Marrow Cells
Bone Marrow Transplantation
Clone Cells
Culture Techniques
Dinitrophenols
Epitopes
Flagella
Haptens
Humans
Hybridization, Genetic
Immune Sera
Mice
Mice, Inbred Strains
Phenylacetates
Salmonella
Serum Albumin, Bovine
Spleen
T-Lymphocytes
Transplantation, Homologous
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
213,668,512Genes and antibodies.Science1959https://conductscience.org/library/papers/13668512PubMed
34,117,564Effect of immunological unresponsiveness on different cell populations.Transplant Rev1972https://conductscience.org/library/papers/4117564PubMed
44,119,591Fate of antigen-binding cells in unresponsive and immune mice.J Exp Med1973https://conductscience.org/library/papers/4119591PubMed
54,125,922Immunological unresponsiveness.Adv Immunol1973https://conductscience.org/library/papers/4125922PubMed
64,132,995Induction of immunological tolerance to a thymus-dependent antigen in the absence of thymus-derived cells.J Exp Med1974https://conductscience.org/library/papers/4132995PubMed
74,134,000T cell modification of B cell responses to antigen in mice.Contemp Top Immunobiol1974https://conductscience.org/library/papers/4134000PubMed
84,141,645Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling.Cell Immunol1974https://conductscience.org/library/papers/4141645PubMed
94,142,364Principles of immunological tolerance and immunocyte receptor blockade.Adv Cancer Res1974https://conductscience.org/library/papers/4142364PubMed
104,168,614Primary immune response in cultures of spleen cells.Lancet1967https://conductscience.org/library/papers/4168614PubMed
114,279,889Differentiation of lymphocytes in the mouse bone marrow. III. The adoptive response of bone marrow cells to a thymus cell-independent antigen.Immunology1974https://conductscience.org/library/papers/4279889PubMed

1 to 10 of 22

See all 22 references

Cited by67

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 291 citations.

PMIDTitleJournalYearIn PapersSource
40,297,057Alzheimer's disease and the immune system: A comprehensive overview with a focus on B cells, humoral immunity, and immunotherapy.J Alzheimers Dis Rep2025https://conductscience.org/library/papers/40297057PubMed
34,937,915The foundations of immune checkpoint blockade and the ipilimumab approval decennial.Nat Rev Drug Discov2022https://conductscience.org/library/papers/34937915PubMed
31,616,406Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases.Front Immunol2019https://conductscience.org/library/papers/31616406PubMed
29,449,887Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.Thyroid Res2018https://conductscience.org/library/papers/29449887PubMed
24,795,433Restoring the balance: immunotherapeutic combinations for autoimmune disease.Dis Model Mech2014https://conductscience.org/library/papers/24795433PubMed
24,127,845Immunosenescence and immune response in organ transplantation.Int Rev Immunol2014https://conductscience.org/library/papers/24127845PubMed
20,655,723B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.Transplant Rev (Orlando)2010https://conductscience.org/library/papers/20655723PubMed
20,209,168Kinetic modeling reveals a common death niche for newly formed and mature B cells.PLoS One2010https://conductscience.org/library/papers/20209168PubMed
20,161,663B-cell tolerance in transplantation: is repertoire remodeling the answer?Expert Rev Clin Immunol2009https://conductscience.org/library/papers/20161663PubMed
19,843,930Establishing anergy as a bona fide in vivo mechanism of B cell tolerance.J Immunol2009https://conductscience.org/library/papers/19843930PubMed

1 to 10 of 67

See all 67 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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