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Paper · 3889907

A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors.

Pike BL and 1 other. Proc Natl Acad Sci U S A, 1985. Cited by 40 papers, by iCite.

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ConductScience Library. A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors. Papers, record 3889907. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3889907

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1985
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
40
iCite
Relative citation ratio, by iCite
0.75
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pike BLB L
2Nossal GJG J

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Growth SubstancesMajor topic
LymphokinesMajor topic
Animals
Antibody Formation
Antibody-Producing Cells
Biological Assay
Cell Differentiation
Cell Division
Cells, Cultured
Enzyme-Linked Immunosorbent Assay
Fibroblasts
Haptens
Hemolytic Plaque Technique
Interleukin-4
Mice

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
AI-03958NIAID NIH HHSUnited StatesR01AI003958PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1300,377Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.J Biol Chem1977https://conductscience.org/library/papers/300377PubMed
26,199,407A reappraisal of "T-independent" antigens. I. Effect of lymphokines on the response of single adult hapten-specific B lymphocytes.J Immunol1984https://conductscience.org/library/papers/6199407PubMed
3303,681Regulation of B-lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors.J Exp Med1977https://conductscience.org/library/papers/303681PubMed
4350,592Sequential use of hapten-gelatin fractionation and fluorescence-activated cell sorting in the enrichment of hapten-specific B llymphocytes.Eur J Immunol1978https://conductscience.org/library/papers/350592PubMed
5105,075Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load.J Exp Med1979https://conductscience.org/library/papers/105075PubMed
66,967,311Granulocyte/macrophage-, megakaryocyte-, eosinophil- and erythroid-colony-stimulating factors produced by mouse spleen cells.Biochem J1980https://conductscience.org/library/papers/6967311PubMed
757,094Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes.Immunology1976https://conductscience.org/library/papers/57094PubMed
86,159,416Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.J Immunol1980https://conductscience.org/library/papers/6159416PubMed
96,161,187Activation of murine B lymphocytes. III. Stimulation of B lymphocyte clonal growth with lipopolysaccharide and dextran sulfate.J Immunol1981https://conductscience.org/library/papers/6161187PubMed
107,009,407Strategies for the analysis of accessory-cell function: the in vitro cloning and characterization of the P cell.Immunol Rev1980https://conductscience.org/library/papers/7009407PubMed

1 to 10 of 35

See all 35 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 40 citations.

PMIDTitleJournalYearIn PapersSource
8,503,867Cellular signalling mechanisms in B lymphocytes.Biochem J1993https://conductscience.org/library/papers/8503867PubMed
3,877,937Interleukin 1 can act as a B-cell growth and differentiation factor.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3877937PubMed
3,495,004Clonal analysis of the anti-DNA repertoire of murine B lymphocytes.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3495004PubMed
3,493,492Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3493492PubMed
3,110,787T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3110787PubMed
3,110,347Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.J Exp Med1987https://conductscience.org/library/papers/3110347PubMed
3,049,907Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.J Exp Med1988https://conductscience.org/library/papers/3049907PubMed
2,786,635Sudden appearance of anti-protein IgG1-forming cell precursors early during primary immunization.Proc Natl Acad Sci U S A1989https://conductscience.org/library/papers/2786635PubMed
1,371,126Selective induction of rheumatoid factors by superantigens and human helper T cells.J Clin Invest1992https://conductscience.org/library/papers/1371126PubMed
1,348,366Memory cell generation ablated by soluble protein antigen by means of effects on T- and B-lymphocyte compartments.Proc Natl Acad Sci U S A1992https://conductscience.org/library/papers/1348366PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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