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Paper · 31900366

Identification and characterization of extrachromosomal circular DNA in maternal plasma.

Sin STK and 9 others. Proc Natl Acad Sci U S A, 2020. Cited by 147 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Identification and characterization of extrachromosomal circular DNA in maternal plasma. Papers, record 31900366. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31900366

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Identification and characterization of extrachromosomal circular DNA in maternal plasma.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
2020
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
147
iCite
Relative citation ratio, by iCite
5.87
iCite
Revised in PubMed
2020-04-27
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sin STKSarah T K
2Jiang PPeiyong
3Deng JJiaen
4Ji LLu
5Cheng SHSuk Hang
6Dutta AAnindya
7Leung TYTak Y
8Chan KCAK C Allen
9Chiu RWKRossa W K
10Lo YMDY M Dennishttps://orcid.org/0000-0001-8746-0293

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell-Free Nucleic AcidsMajor topic
DNA, CircularMajor topic
PlasmaMajor topic
Female
Genome, Human
Hong Kong
Humans
Noninvasive Prenatal Testing
Pregnancy

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
125,646,427Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.Proc Natl Acad Sci U S A2015https://conductscience.org/library/papers/25646427PubMed
224,843,150Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing.Proc Natl Acad Sci U S A2014https://conductscience.org/library/papers/24843150PubMed
326,038,577Extrachromosomal circular DNA is common in yeast.Proc Natl Acad Sci U S A2015https://conductscience.org/library/papers/26038577PubMed
422,052,939Nonhematopoietically derived DNA is shorter than hematopoietically derived DNA in plasma: a transplantation model.Clin Chem2012https://conductscience.org/library/papers/22052939PubMed
530,808,726Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.Genome Res2019https://conductscience.org/library/papers/30808726PubMed
69,274,585Presence of fetal DNA in maternal plasma and serum.Lancet1997https://conductscience.org/library/papers/9274585PubMed
72,079,966Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells.Mutat Res1990https://conductscience.org/library/papers/2079966PubMed
827,899,652Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity.Nucleic Acids Res2017https://conductscience.org/library/papers/27899652PubMed
915,289,578Origin of the intrinsic rigidity of DNA.Nucleic Acids Res2004https://conductscience.org/library/papers/15289578PubMed
1020,110,278BEDTools: a flexible suite of utilities for comparing genomic features.Bioinformatics2010https://conductscience.org/library/papers/20110278PubMed

1 to 10 of 37

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Cited by111

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 147 citations.

PMIDTitleJournalYearIn PapersSource
42,826,178Reappraising the topology of cell-free fetal DNA in maternal blood toward improved prenatal genetic diagnostics.Sci Adv2026https://conductscience.org/library/papers/42826178PubMed
42,712,436Discovery and validation of GNA12circle as a first-trimester plasma eccDNA marker for early-onset preeclampsia.Front Neurol2026https://conductscience.org/library/papers/42712436PubMed
42,332,569Circle-seq analysis reveals the involvement of eccDNAs in salt stress response of bermudagrass (Cynodon dactylon).BMC Genomics2026https://conductscience.org/library/papers/42332569PubMed
42,243,982Deciphering the role of cell-free extrachromosomal circular DNA in human heart failure.Hum Genomics2026https://conductscience.org/library/papers/42243982PubMed
41,987,223Convergent evolution of complex structural variants drives therapy resistance in metastatic prostate cancer.Genome Biol2026https://conductscience.org/library/papers/41987223PubMed
41,947,008Galectin-9high Neutrophils Exacerbate Radiation-Induced Frailty.Aging Cell2026https://conductscience.org/library/papers/41947008PubMed
41,724,384An enhancement of extrachromosomal circular DNA enrichment and amplification to address the extremely low overlap between replicates.J Biol Chem2026https://conductscience.org/library/papers/41724384PubMed
41,691,146Extrachromosomal circular DNA: a potential clinical therapeutic target in malignant tumors.Cell Mol Biol Lett2026https://conductscience.org/library/papers/41691146PubMed
41,640,667The potential clinical implications of extrachromosomal circular DNA as a biomarker.Genes Dis2026https://conductscience.org/library/papers/41640667PubMed
41,542,081Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia.Comput Struct Biotechnol J2025https://conductscience.org/library/papers/41542081PubMed

1 to 10 of 111

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DR11,810PubTator's text mininghttps://conductscience.org/library/genes/1810NCBI Gene
EXO564,789PubTator's text mininghttps://conductscience.org/library/genes/64789NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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