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Paper · 32066950

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.

Weisel FJ and 16 others. Nat Immunol, 2020. Cited by 241 papers, by iCite.

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ConductScience Library. Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis. Papers, record 32066950. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32066950

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.
PubMed
Journal
Nat Immunol
PubMed
Year
2020
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
241
iCite
Relative citation ratio, by iCite
8.94
iCite
Revised in PubMed
2022-04-18
PubMed

Authors17

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Weisel FJFlorian Jhttps://orcid.org/0000-0002-8679-9241
2Mullett SJSteven J
3Elsner RARebecca A
4Menk AVAshley V
5Trivedi NNikita
6Luo WWeihttps://orcid.org/0000-0003-2826-1723
7Wikenheiser DDaniel
8Hawse WFWilliam F
9Chikina MMaria
10Smita SShuchi

1 to 10 of 17Source PubMed

See all 17 authors

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Fatty AcidsMajor topic
Germinal CenterMajor topic
Animals
Cell Proliferation
Energy Metabolism
Fatty Acids, Nonesterified
Gene Expression
Glucose
Glycolysis
In Vitro Techniques
Metabolome
Mice
Mice, Inbred BALB C
Mice, Knockout
Oxidation-Reduction
Oxidative Phosphorylation
Oxygen Consumption

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK114012NIDDK NIH HHSUnited StatesR01DK114012PubMed and NIHNIH RePORTER
S10 OD011925NIH HHSUnited StatesS10OD011925PubMed and NIHNIH RePORTER
S10 OD023402NIH HHSUnited StatesS10OD023402PubMed and NIHNIH RePORTER
R01 AI105018NIAID NIH HHSUnited StatesR01AI105018PubMed and NIHNIH RePORTER
T32 AI089443NIAID NIH HHSUnited StatesT32AI089443PubMed and NIHNIH RePORTER
S10 OD019942NIH HHSUnited StatesS10OD019942PubMed and NIHNIH RePORTER
R01 AI043603NIAID NIH HHSUnited StatesR01AI043603PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections3

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in32,066,952B is for 'Big Mac': GCs crave a high-fat diet.https://conductscience.org/library/papers/32066952PubMed
Comment in32,375,061Dietary Fat Makes Germinal Center B Cells Happy.https://conductscience.org/library/papers/32375061PubMed
Comment in32,382,129The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells.https://conductscience.org/library/papers/32382129PubMed

References59

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,654,945Impaired germinal center reaction in mice with short telomeres.EMBO J2000https://conductscience.org/library/papers/10654945PubMed
229,999,501αv Integrins regulate germinal center B cell responses through noncanonical autophagy.J Clin Invest2018https://conductscience.org/library/papers/29999501PubMed
317,723,214Germinal-center organization and cellular dynamics.Immunity2007https://conductscience.org/library/papers/17723214PubMed
430,874,348B cell primary immune responses.Immunol Rev2019https://conductscience.org/library/papers/30874348PubMed
524,655,299Metabolic regulation of immune responses.Annu Rev Immunol2014https://conductscience.org/library/papers/24655299PubMed
630,602,764Metabolism as a guiding force for immunity.Nat Cell Biol2019https://conductscience.org/library/papers/30602764PubMed
723,601,682Metabolic pathways in immune cell activation and quiescence.Immunity2013https://conductscience.org/library/papers/23601682PubMed
825,857,523Mitochondrial function provides instructive signals for activation-induced B-cell fates.Nat Commun2015https://conductscience.org/library/papers/25857523PubMed
925,786,173Mitochondria in the regulation of innate and adaptive immunity.Immunity2015https://conductscience.org/library/papers/25786173PubMed
1030,240,649Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling.iScience2018https://conductscience.org/library/papers/30240649PubMed

1 to 10 of 59

See all 59 references

Cited by177

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 241 citations.

PMIDTitleJournalYearIn PapersSource
42,982,553EFhd2 regulates microtubule-dependent mitochondrial fitness at the B cell immune synapse.Life Sci Alliance2027https://conductscience.org/library/papers/42982553PubMed
42,959,688Biotin-dependent metabolism controls germinal center fate and vaccine-induced antibody diversification.iScience2026https://conductscience.org/library/papers/42959688PubMed
42,956,059Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling.Elife2026https://conductscience.org/library/papers/42956059PubMed
42,951,872Adaptive immune plasticity in MASH: Functional states, pathological consequences, and regulatory mechanisms.Hepatol Commun2026https://conductscience.org/library/papers/42951872PubMed
42,858,645A mature tertiary lymphoid structure-associated spatial niche is inversely associated with ACC1-related lipid metabolism in neoadjuvant-treated hepatocellular carcinoma.Transl Oncol2026https://conductscience.org/library/papers/42858645PubMed
42,844,382A guide to B cell metabolism.Nat Rev Immunol2026https://conductscience.org/library/papers/42844382PubMed
42,706,436HnRNPK restrains memory precursor and plasma cell differentiation to control germinal center B-cell output.Cell Mol Immunol2026https://conductscience.org/library/papers/42706436PubMed
42,650,872Shared Major Metabolic Pathways and Potential Targeted Therapies in Malignancies and Systemic Lupus Erythematosus.Biomolecules2026https://conductscience.org/library/papers/42650872PubMed
42,636,358SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/42636358PubMed
42,634,089Metabolic switch: lymphocytes and the onset of T-cell-mediated autoimmunity.Cell Mol Immunol2026https://conductscience.org/library/papers/42634089PubMed

1 to 10 of 177

See all 177 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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