ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 329276

Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase.

Yamane T and 1 other. Proc Natl Acad Sci U S A, 1977. Cited by 56 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase. Papers, record 329276. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/329276

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
56
iCite
Relative citation ratio, by iCite
1.03
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yamane TT
2Hopfield JJJ J

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Amino Acyl-tRNA SynthetasesMajor topic
Isoleucine-tRNA LigaseMajor topic
RNA, TransferMajor topic
Transfer RNA AminoacylationMajor topic
Tyrosine-tRNA LigaseMajor topic
Valine-tRNA LigaseMajor topic
Escherichia coli
Kinetics
N-Formylmethionine
Phenylalanine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References44

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
113,841,480The specificity of protein biosynthesis.Adv Protein Chem1959https://conductscience.org/library/papers/13841480PubMed
25,803,296Recognition of tRNA by isoleucyl-tRNA synthetase. Effect of substrates on the dynamics of tRNA-enzyme interaction.J Mol Biol1969https://conductscience.org/library/papers/5803296PubMed
3264,694A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/264694PubMed
4319,457Proofreading of the codon-anticodon interaction on ribosomes.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/319457PubMed
5795,646Interpretation of tRNA-mischarging kinetics.Eur J Biochem1976https://conductscience.org/library/papers/795646PubMed
6786,371Energy metabolism of Saccharomyces cerevisiae discrepancy between ATP balance and known metabolic functions.Biochim Biophys Acta1976https://conductscience.org/library/papers/786371PubMed
7786,367Hydrolytic action of aminoacyl-tRNA synthetases from baker's yeast: "chemical proofreading" preventing acylation of tRNA(I1e) with misactivated valine.Biochemistry1976https://conductscience.org/library/papers/786367PubMed
84,604,278Correction of aminoacylation errors: evidence for a non significant role of the aminoacyl-tRNA synthetase catalysed deacylation of aminoacyl-tRNAs.FEBS Lett1974https://conductscience.org/library/papers/4604278PubMed
94,373,457Structural requirements for recognition of Escherichia coli initiator and non-initiator transfer ribonucleic acids by bacterial T factor.J Biol Chem1974https://conductscience.org/library/papers/4373457PubMed
104,604,598Incorrect aminoacylations involving tRNAs or valyl-tRNA synthetase from Bacillus stearothermophilus.Eur J Biochem1974https://conductscience.org/library/papers/4604598PubMed

1 to 10 of 44

See all 44 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 56 citations.

PMIDTitleJournalYearIn PapersSource
41,724,766Non-enzymatic error correction in self-replicators without extraneous energy supply.Sci Rep2026https://conductscience.org/library/papers/41724766PubMed
33,357,378Proofreading through spatial gradients.Elife2020https://conductscience.org/library/papers/33357378PubMed
32,687,854The Intrinsically Disordered N-terminal Extension of the ClpS Adaptor Reprograms Its Partner AAA+ ClpAP Protease.J Mol Biol2020https://conductscience.org/library/papers/32687854PubMed
28,208,756Homocysteine Editing, Thioester Chemistry, Coenzyme A, and the Origin of Coded Peptide Synthesis †.Life (Basel)2017https://conductscience.org/library/papers/28208756PubMed
28,138,071A recent intermezzo at the Ribosome Club.Philos Trans R Soc Lond B Biol Sci2017https://conductscience.org/library/papers/28138071PubMed
27,489,144Intrinsic limits to gene regulation by global crosstalk.Nat Commun2016https://conductscience.org/library/papers/27489144PubMed
27,223,819Aminoacyl-tRNA Synthetases in the Bacterial World.EcoSal Plus2016https://conductscience.org/library/papers/27223819PubMed
26,670,257Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification.Life (Basel)2015https://conductscience.org/library/papers/26670257PubMed
22,786,930Speed, dissipation, and error in kinetic proofreading.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22786930PubMed
21,843,463Kinetic proofreading in chromatin remodeling: the case of ISWI/ACF.Biophys J2011https://conductscience.org/library/papers/21843463PubMed

1 to 10 of 20

See all 20 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
MT-TG4,563PubTator's text mininghttps://conductscience.org/library/genes/4563NCBI Gene
VARS17,407PubTator's text mininghttps://conductscience.org/library/genes/7407NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/329276

GET https://conductscience.org/api/papers/v1/329276/references?page=2

API referenceFor AI assistants