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Paper33118

The capacity of microsomally-activated cyclophosphamide to induce immunosuppression in vitro.

Shand FL. Immunology, 1978. Cited by 20 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The capacity of microsomally-activated cyclophosphamide to induce immunosuppression in vitro. Papers, record 33118. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33118

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The capacity of microsomally-activated cyclophosphamide to induce immunosuppression in vitro.
PubMed
Journal
Immunology
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
20
iCite
Relative citation ratio, by iCite
0.83
iCite
Revised in PubMed
2021-12-03
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Shand FLF L

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody FormationMajor topic
CyclophosphamideMajor topic
Animals
B-Lymphocytes
Female
Graft vs Host Reaction
Immunologic Capping
Immunosuppression Therapy
In Vitro Techniques
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Microsomes, Liver
Rats
Receptors, Antigen, B-Cell
T-Lymphocytes

Source PubMed

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,181Analysis of immunosuppression generated by the graft-versus-host reaction. II. Characterization of the suppression cell and its mechanism of action.Immunology1976https://conductscience.org/library/papers/11181PubMed
21,277,205Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds.Cancer Treat Rep1976https://conductscience.org/library/papers/1277205PubMed
314,208,670[ON THE ACTIVATION OF CYCLOPHOSPHAMIDE IN VIVO AND IN VITRO].Arzneimittelforschung1963https://conductscience.org/library/papers/14208670PubMed
4304,528Cyclophosphamide inhibited B cell receptor regeneration as a basis for drug-induced tolerance;.Nature1978https://conductscience.org/library/papers/304528PubMed
5324,776Regulation of the immune response. II. Repressor T cells in cyclophosphamide-induced tolerant mice.Eur J Immunol1977https://conductscience.org/library/papers/324776PubMed
6325Analysis of immunosuppression generated by the graft-versus-host reaction. I. A suppressor T-cell component studied in vivo.Immunology1975https://conductscience.org/library/papers/325PubMed
74,177,548Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro.Biochem J1968https://conductscience.org/library/papers/4177548PubMed
84,393,964The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens.J Immunol1970https://conductscience.org/library/papers/4393964PubMed
94,394,274A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.Transplantation1970https://conductscience.org/library/papers/4394274PubMed
104,398,015Microsomal activation of cyclophosphamide in vivo.Biochem Pharmacol1970https://conductscience.org/library/papers/4398015PubMed
114,405,409Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice.Immunology1972https://conductscience.org/library/papers/4405409PubMed
124,811,053Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide.Biochem Pharmacol1974https://conductscience.org/library/papers/4811053PubMed
134,934,348The effect of cytotoxic drugs on graft-versus-host disease in mice.Transplantation1971https://conductscience.org/library/papers/4934348PubMed
144,950,080Periodicity during recovery of immune response after cyclophosphamide treatment.Blood1971https://conductscience.org/library/papers/4950080PubMed
155,046,868Selective depletion of lymphoid tissue by cyclophosphamide.Clin Exp Immunol1972https://conductscience.org/library/papers/5046868PubMed
165,461,623Drug-induced immunologic tolerance: site of action of cyclophosphamide.Proc Soc Exp Biol Med1970https://conductscience.org/library/papers/5461623PubMed

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 20 citations.

PMIDTitleJournalYearIn Papers
159,940
T-suppressor cells sensitive to cyclophosphamide and to its in vitro active derivative 4-hydroperoxycyclophosphamide control the mitogenic response of murine splenic B cells to dextran sulfate. A direct proof for different sensitivities of lymphocyte subsets to cyclophosphamide.
J Exp Med1979https://conductscience.org/library/papers/159940

Source PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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