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Paper · 33749593

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.

Tawfik B and 8 others. Elife, 2021. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming. Papers, record 33749593. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33749593

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.
PubMed
Journal
Elife
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
24
iCite
Relative citation ratio, by iCite
1.36
iCite
Revised in PubMed
2021-09-09
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tawfik BBassamhttps://orcid.org/0000-0003-1193-8494
2Martins JSJoana S
3Houy SSébastienhttps://orcid.org/0000-0003-3639-1931
4Imig CCordeliahttps://orcid.org/0000-0001-7351-8706
5Pinheiro PSPaulo S
6Wojcik SMSonja M
7Brose NNils
8Cooper BHBenjamin H
9Sørensen JBJakob Balslevhttps://orcid.org/0000-0001-5465-3769

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CalciumMajor topic
Cell MembraneMajor topic
Intracellular Signaling Peptides and ProteinsMajor topic
Nerve Tissue ProteinsMajor topic
Secretory VesiclesMajor topic
SynaptotagminsMajor topic
Animals
Chromaffin Cells
Electron Microscope Tomography
Exocytosis
Membrane Fusion
Mice
Mice, Inbred C57BL

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
KU2016University of Copenhagen 2016 excellence programPubMed
NNF19OC0058298Novo Nordisk FoundationPubMed
R221-2016-1202LundbeckfondenPubMed
0134-00141AIndependent Research Fund DenmarkPubMed
R34-A3740LundbeckfondenPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References116

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,792,326Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.Cell2002https://conductscience.org/library/papers/11792326PubMed
221,551,071Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells.Mol Biol Cell2011https://conductscience.org/library/papers/21551071PubMed
328,521,135Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse.Neuron2017https://conductscience.org/library/papers/28521135PubMed
425,374,362The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.Neuron2014https://conductscience.org/library/papers/25374362PubMed
511,998,689Vesicle pools and short-term synaptic depression: lessons from a large synapse.Trends Neurosci2002https://conductscience.org/library/papers/11998689PubMed
624,985,331How could SNARE proteins open a fusion pore?Physiology (Bethesda)2014https://conductscience.org/library/papers/24985331PubMed
710,433,271Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices.Neuron1999https://conductscience.org/library/papers/10433271PubMed
833,369,005Biogenesis of large dense core vesicles in mouse chromaffin cells.Traffic2021https://conductscience.org/library/papers/33369005PubMed
926,437,117Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.PLoS Biol2015https://conductscience.org/library/papers/26437117PubMed
1021,642,968Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.Nat Struct Mol Biol2011https://conductscience.org/library/papers/21642968PubMed

1 to 10 of 116

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Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMIDTitleJournalYearIn PapersSource
41,665,484Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex.Elife2026https://conductscience.org/library/papers/41665484PubMed
41,629,537SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons.Commun Biol2026https://conductscience.org/library/papers/41629537PubMed
40,666,287Cellular mechanisms of hormone secretion in neuroendocrine tumors: what goes wrong?Front Cell Dev Biol2025https://conductscience.org/library/papers/40666287PubMed
40,205,739SNARE complex assembly and disassembly dynamics in response to Ca2+ current activation in live cells.Biophys J2025https://conductscience.org/library/papers/40205739PubMed
39,585,326Key determinants of the dual clamp/activator function of Complexin.Elife2024https://conductscience.org/library/papers/39585326PubMed
39,429,212Biomarkers of mature neuronal differentiation and related diseases.Future Sci OA2024https://conductscience.org/library/papers/39429212PubMed
39,082,978Exploring the structural dynamics of the vesicle priming machinery.Biochem Soc Trans2024https://conductscience.org/library/papers/39082978PubMed
38,536,730Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release.Elife2024https://conductscience.org/library/papers/38536730PubMed
38,262,726Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.J Neurosci2024https://conductscience.org/library/papers/38262726PubMed
38,170,748All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle priming.Proc Natl Acad Sci U S A2024https://conductscience.org/library/papers/38170748PubMed

1 to 10 of 19

See all 19 cited by

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
SNAR-E100,170,220PubTator's text mininghttps://conductscience.org/library/genes/100170220NCBI Gene
SYT16,857PubTator's text mininghttps://conductscience.org/library/genes/6857NCBI Gene
SYT2127,833PubTator's text mininghttps://conductscience.org/library/genes/127833NCBI Gene
SYT79,066PubTator's text mininghttps://conductscience.org/library/genes/9066NCBI Gene
SYT9143,425PubTator's text mininghttps://conductscience.org/library/genes/143425NCBI Gene
UNC13B10,497PubTator's text mininghttps://conductscience.org/library/genes/10497NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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