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Paper · 34192547

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes.

Abu-Odeh M and 18 others. Cell Rep, 2021. Cited by 90 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Papers, record 34192547. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34192547

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes.
PubMed
Journal
Cell Rep
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
90
iCite
Relative citation ratio, by iCite
5.63
iCite
Revised in PubMed
2023-03-30
PubMed

Authors19

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Abu-Odeh MMohammad
2Zhang YYuan
3Reilly SMShannon M
4Ebadat NNima
5Keinan OOmer
6Valentine JMJoseph M
7Hafezi-Bakhtiari MMaziar
8Ashayer HHadeel
9Mamoun LLana
10Zhou XXin

1 to 10 of 19Source PubMed

See all 19 authors

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AdipocytesMajor topic
Autocrine CommunicationMajor topic
Fibroblast Growth FactorsMajor topic
Gene Expression RegulationMajor topic
ThermogenesisMajor topic
3T3-L1 Cells
Adipose Tissue, Brown
Adipose Tissue, White
Adrenergic beta-Agonists
Animals
Lipolysis
Liver
Mice
Organ Specificity
Protein Binding
RNA, Messenger
Receptors, Adrenergic, beta-3
Receptors, Fibroblast Growth Factor

Source PubMed

Grants22

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK125820NIDDK NIH HHSUnited StatesR01DK125820PubMed and NIHNIH RePORTER
T32 DK007044NIDDK NIH HHSUnited StatesT32DK007044PubMedNIH RePORTER
R01 DK124496NIDDK NIH HHSUnited StatesR01DK124496PubMed and NIHNIH RePORTER
R01 AA028473NIAAA NIH HHSUnited StatesR01AA028473PubMed and NIHNIH RePORTER
R01 DK120480NIDDK NIH HHSUnited StatesR01DK120480PubMed and NIHNIH RePORTER
K01 DK105075NIDDK NIH HHSUnited StatesK01DK105075PubMed and NIHNIH RePORTER
R01 DK126944NIDDK NIH HHSUnited StatesR01DK126944PubMed and NIHNIH RePORTER
R01 DK122804NIDDK NIH HHSUnited StatesR01DK122804PubMed and NIHNIH RePORTER
R01 DK073368NIDDK NIH HHSUnited StatesR01DK073368PubMed and NIHNIH RePORTER
R01 DK076906NIDDK NIH HHSUnited StatesR01DK076906PubMed and NIHNIH RePORTER

1 to 10 of 22

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in34,290,395Autocrine FGF21 signalling promotes beiging.https://conductscience.org/library/papers/34290395

Source PubMed

References60

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,018,895FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.J Biol Chem2010https://conductscience.org/library/papers/20018895PubMed
224,096,302Development of small-molecule inhibitors targeting adipose triglyceride lipase.Nat Chem Biol2013https://conductscience.org/library/papers/24096302PubMed
37,644,477A synthetic inhibitor of the mitogen-activated protein kinase cascade.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7644477PubMed
421,317,437Thermogenic activation induces FGF21 expression and release in brown adipose tissue.J Biol Chem2011https://conductscience.org/library/papers/21317437PubMed
526,635,723Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity.Front Endocrinol (Lausanne)2015https://conductscience.org/library/papers/26635723PubMed
616,260,143Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling.Trends Biochem Sci2005https://conductscience.org/library/papers/16260143PubMed
725,956,583Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.Cell Rep2015https://conductscience.org/library/papers/25956583PubMed
817,550,778Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.Cell Metab2007https://conductscience.org/library/papers/17550778PubMed
919,819,944Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.Endocrinology2009https://conductscience.org/library/papers/19819944PubMed
1024,090,673Adrenergic pathway activation enhances brown adipose tissue metabolism: a [¹⁸F]FDG PET/CT study in mice.Nucl Med Biol2014https://conductscience.org/library/papers/24090673PubMed

1 to 10 of 60

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Cited by62

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 90 citations.

PMIDTitleJournalYearIn PapersSource
42,883,860Canonical and Non-Canonical Regulators of Lipid Metabolism in the Liver and the "Liver-Other Organs" Axes.Int J Mol Sci2026https://conductscience.org/library/papers/42883860PubMed
42,825,310βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry.Korean J Physiol Pharmacol2026https://conductscience.org/library/papers/42825310PubMed
42,706,243Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.Nat Commun2026https://conductscience.org/library/papers/42706243PubMed
42,639,474The hallmarks of protein and amino acid restriction in aging and longevity.Cell Press Blue2026https://conductscience.org/library/papers/42639474PubMed
42,627,910Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism.Sci Adv2026https://conductscience.org/library/papers/42627910PubMed
42,511,610Alternative Receptor Signaling for the Selective and Multifaceted Regulation of Human Brown Adipocytes.Int J Mol Sci2026https://conductscience.org/library/papers/42511610PubMed
42,439,678Follistatin Mitigates Atherosclerosis Through Activation of Arginine Metabolism and Adipose Browning.Cells2026https://conductscience.org/library/papers/42439678PubMed
42,352,318Exercise Intensity and Circulating Exerkine Responses: A Narrative Review of Selected Molecules.Biomolecules2026https://conductscience.org/library/papers/42352318PubMed
42,313,341The role of fibroblast growth factor 21 in diabetes and metabolic dysfunction.Mol Biol Rep2026https://conductscience.org/library/papers/42313341PubMed
42,274,873Integrative Genomic and Transcriptomic Insights into High-Altitude Adaptation in Changthangi Goats.Appl Biochem Biotechnol2026https://conductscience.org/library/papers/42274873PubMed

1 to 10 of 62

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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