Paper · 17550778

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Badman MK and 5 others. Cell Metab, 2007. Cited by 1,328 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Papers, record 17550778. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17550778

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.; PubMed
Journal: Cell Metab; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17550778/; PubMed
DOI: https://doi.org/10.1016/j.cmet.2007.05.002; PubMed
The journal: https://conductscience.org/library/journal-index/101233170; PubMed
Citations, by iCite: 1,328; iCite
Relative citation ratio, by iCite: 30.3; iCite
Revised in PubMed: 2024-01-09; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Badman MK	Michael K
2	Pissios P	Pavlos
3	Kennedy AR	Adam R
4	Koukos G	George
5	Flier JS	Jeffrey S
6	Maratos-Flier E	Eleftheria

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Fibroblast Growth Factors	Major topic
Hepatocytes	Major topic
Lipid Metabolism	Major topic
Liver	Major topic
PPAR alpha	Major topic
Adenoviridae
Animals
Cells, Cultured
Fenofibrate
Gene Expression Regulation
Hypolipidemic Agents
Immunoblotting
Ketosis
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Oligonucleotide Array Sequence Analysis
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Transfection

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P01 DK056116	NIDDK NIH HHS	United States	P01DK056116	PubMed and NIH	NIH RePORTER
R01 DK069983	NIDDK NIH HHS	United States	R01DK069983	PubMed and NIH	NIH RePORTER
HL-48739	NHLBI NIH HHS	United States	R01HL048739	PubMed and NIH	NIH RePORTER
5P30DK46200-14	NIDDK NIH HHS	United States	P30DK462001	PubMed	NIH RePORTER
			P30DK046200	NIH	NIH RePORTER
			R01DK056113	NIH	NIH RePORTER

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record	Source
NCT01911091	Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus)	Background		ClinicalTrials.gov
NCT03369145	High-fat Overfeeding, Hepatokines and Appetite Regulation	Background		ClinicalTrials.gov

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	17,550,773	FGF21: a missing link in the biology of fasting.	https://conductscience.org/library/papers/17550773

Source PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by840

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,328 citations.

PMID	Title	Journal	Year	In Papers	Source
42,957,849	Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging.	Mol Biomed	2026	https://conductscience.org/library/papers/42957849	PubMed
42,948,748	Emerging insights into PPARα's role in lean metabolic dysfunction-associated steatotic liver disease: Implications for targeted therapies.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42948748	PubMed
42,709,008	Fenofibrate Protects Against Antipsychotic-Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms.	FASEB J	2026	https://conductscience.org/library/papers/42709008	PubMed
42,653,122	Beneficial Hepatokines in MASLD/MASH: Therapeutic Potentials and Drug Delivery Challenges.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42653122	PubMed
42,587,786	Adipose Tissue Dysfunction in Metabolic Dysfunction-Associated Steatotic Liver Disease.	Cells	2026	https://conductscience.org/library/papers/42587786	PubMed
42,564,630	Adipokine in Metabolic Liver Disease: Adipo-Brain-Liver Cross talk.	Int J Endocrinol	2026	https://conductscience.org/library/papers/42564630	PubMed
42,512,119	Apabetalone Drives a Metabolic Shift Towards Ketogenesis and Reduces Liver Steatosis in Diet-Induced Obesity Mice.	Biomedicines	2026	https://conductscience.org/library/papers/42512119	PubMed
42,441,528	PPARα Dependent Regulation of Gut Microbiota: Implication for Host Metabolic Homeostasis.	Mol Nutr Food Res	2026	https://conductscience.org/library/papers/42441528	PubMed
42,440,064	PLX3397 Reshapes Hepatic Lipid Metabolism Independent of Microglial Depletion.	Neurosci Bull	2026	https://conductscience.org/library/papers/42440064	PubMed
42,305,630	Screening and validation of rabbit monoclonal antibody pair against human FGF21 for human plasma FGF21 high sensitivity bioanalysis.	iScience	2026	https://conductscience.org/library/papers/42305630	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
PPARA	5,465	PubTator's text mining	https://conductscience.org/library/genes/5465

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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