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Paper · 42957849

Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging.

Salmón-Gómez L and 6 others. Mol Biomed, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging. Papers, record 42957849. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42957849

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging.
Journal
Mol Biomed
Year
2026
Publication types
Journal Article, Review
Revised in PubMed
2026-11-01

Source PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Salmón-Gómez LLaurahttps://orcid.org/0000-0002-7223-512X
2Keipert SSusannehttps://orcid.org/0000-0002-6618-7379
3Catalán VVictoriahttps://orcid.org/0000-0002-7513-7509
4Rodríguez AAmaiahttps://orcid.org/0000-0002-2180-461X
5Becerril SSarahttps://orcid.org/0000-0002-3441-1970
6Frühbeck GGemahttps://orcid.org/0000-0002-8305-7154
7Gómez-Ambrosi JJavierhttps://orcid.org/0000-0001-5601-1604

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fibroblast Growth FactorsMajor topic
Growth Differentiation Factor 15Major topic
AgingMajor topic
Metabolic DiseasesMajor topic
Humans
Animals
Signal Transduction

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
PI20/00080Instituto de Salud Carlos IIIPubMed
PI23/00208Instituto de Salud Carlos IIIPubMed
PI25/00528Instituto de Salud Carlos IIIPubMed
CIBEROBNInstituto de Salud Carlos IIIPubMed
58/2021Departamento de Salud, Gobierno de NavarraPubMed
PI24/01147Instituto de Salud Carlos IIIPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References373

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
137,658,393The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China.BMC Endocr Disord2023https://conductscience.org/library/papers/37658393PubMed
229,222,479GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.Sci Rep2017https://conductscience.org/library/papers/29222479PubMed
333,944,779OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.Elife2021https://conductscience.org/library/papers/33944779PubMed
433,872,851FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages.Int Immunopharmacol2021https://conductscience.org/library/papers/33872851PubMed
529,424,246Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats.Diab Vasc Dis Res2018https://conductscience.org/library/papers/29424246PubMed
628,770,320FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.Diabetologia2017https://conductscience.org/library/papers/28770320PubMed
738,379,856Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes.J Endocr Soc2024https://conductscience.org/library/papers/38379856PubMed
841,358,8932. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2026.Diabetes Care2026https://conductscience.org/library/papers/41358893PubMed
925,083,607Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.Gastroenterology2014https://conductscience.org/library/papers/25083607PubMed
1023,372,041Novel locus including FGF21 is associated with dietary macronutrient intake.Hum Mol Genet2013https://conductscience.org/library/papers/23372041PubMed

1 to 10 of 373

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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