Paper · 33944779

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.

Pereira RO and 18 others. Elife, 2021. Cited by 70 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Papers, record 33944779. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33944779

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.; PubMed
Journal: Elife; PubMed
Year: 2021; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/33944779/; PubMed
DOI: https://doi.org/10.7554/elife.66519; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8128440/; PubMed
The journal: https://conductscience.org/library/journal-index/101579614; PubMed
Citations, by iCite: 70; iCite
Relative citation ratio, by iCite: 3.99; iCite
Revised in PubMed: 2026-05-21; PubMed

Authors19

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Pereira RO	Renata O	https://orcid.org/0000-0001-5809-4669
2	Marti A	Alex
3	Olvera AC	Angela Crystal
4	Tadinada SM	Satya Murthy
5	Bjorkman SH	Sarah Hartwick
6	Weatherford ET	Eric Thomas
7	Morgan DA	Donald A
8	Westphal M	Michael
9	Patel PH	Pooja H	https://orcid.org/0000-0002-5345-0158
10	Kirby AK	Ana Karina

1 to 10 of 19Source PubMed

See all 19 authors

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adipose Tissue, Brown	Major topic
Body Temperature Regulation	Major topic
Fibroblast Growth Factors	Major topic
GTP Phosphohydrolases	Major topic
Gene Deletion	Major topic
Adipocytes, Brown
Adipose Tissue, White
Animals
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity

Source PubMed

Grants12

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
I01 BX000976	BLRD VA	United States	I01BX000976	PubMed	NIH RePORTER
T32 HL007344	NHLBI NIH HHS	United States	T32HL007344	PubMed	NIH RePORTER
R01 HL127764	NHLBI NIH HHS	United States	R01HL127764	PubMed and NIH	NIH RePORTER
R01 AG060637	NIA NIH HHS	United States	R01AG060637	PubMed	NIH RePORTER
T32 DK112751	NIDDK NIH HHS	United States	T32DK112751	PubMed and NIH	NIH RePORTER
P30 DK054759	NIDDK NIH HHS	United States	P30DK054759	PubMed and NIH	NIH RePORTER
R25 GM116686	NIGMS NIH HHS	United States	R25GM116686	PubMed and NIH	NIH RePORTER
15SDG25710438	American Heart Association-American Stroke Association	United States		PubMed	PubMed
R01 HL112413	NHLBI NIH HHS	United States	R01HL112413	PubMed and NIH	NIH RePORTER
T32 DK091317	NIDDK NIH HHS	United States	T32DK091317	PubMed	NIH RePORTER

1 to 10 of 12

See all 12 grants

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References50

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	28,768,181	Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.	Cell Metab	2017	https://conductscience.org/library/papers/28768181	PubMed
2	28,188,284	Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.	J Biol Chem	2017	https://conductscience.org/library/papers/28188284	PubMed
3	29,198,749	Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes.	Mol Metab	2018	https://conductscience.org/library/papers/29198749	PubMed
4	28,552,492	Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.	Cell Metab	2017	https://conductscience.org/library/papers/28552492	PubMed
5	30,679,672	Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure.	Sci Rep	2019	https://conductscience.org/library/papers/30679672	PubMed
6	27,837,773	Obesity Epidemiology Worldwide.	Gastroenterol Clin North Am	2016	https://conductscience.org/library/papers/27837773	PubMed
7	22,433,842	Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.	EMBO J	2012	https://conductscience.org/library/papers/22433842	PubMed
8	29,775,611	Reduced adiposity by compensatory WAT browning upon iBAT removal in mice.	Biochem Biophys Res Commun	2018	https://conductscience.org/library/papers/29775611	PubMed
9	12,161,655	betaAR signaling required for diet-induced thermogenesis and obesity resistance.	Science	2002	https://conductscience.org/library/papers/12161655	PubMed
10	28,539,390	Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.	EMBO Rep	2017	https://conductscience.org/library/papers/28539390	PubMed

1 to 10 of 50

See all 50 references

Cited by54

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 70 citations.

PMID	Title	Journal	Year	In Papers	Source
42,957,849	Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging.	Mol Biomed	2026	https://conductscience.org/library/papers/42957849	PubMed
42,818,311	OPA1 controls mitochondrial dysfunction-driven liver fibrosis in MASLD.	bioRxiv	2026	https://conductscience.org/library/papers/42818311	PubMed
42,521,674	Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.	Signal Transduct Target Ther	2026	https://conductscience.org/library/papers/42521674	PubMed
42,491,461	Cox10-mediated mitochondrial respiration in brown adipocytes regulates adaptive thermogenesis and systemic metabolism.	iScience	2026	https://conductscience.org/library/papers/42491461	PubMed
42,339,133	Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis.	PPAR Res	2026	https://conductscience.org/library/papers/42339133	PubMed
42,182,382	Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets.	bioRxiv	2026	https://conductscience.org/library/papers/42182382	PubMed
42,151,770	Gdf15 expression in thermogenic adipocytes regulates diet-induced weight gain in a sex-dependent manner.	Mol Med	2026	https://conductscience.org/library/papers/42151770	PubMed
41,974,995	GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue.	J Mol Med (Berl)	2026	https://conductscience.org/library/papers/41974995	PubMed
41,799,430	Thermogenesis is limited by cellular competence.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/41799430	PubMed
41,509,390	Acute deletion of PLIN5 in brown adipocytes causes mitochondrial dysfunction and cold intolerance.	bioRxiv	2026	https://conductscience.org/library/papers/41509390	PubMed

1 to 10 of 54

See all 54 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/33944779

GET https://conductscience.org/api/papers/v1/33944779/references?page=2

API reference For AI assistants