Paper · 28539390

Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.

Mahdaviani K and 14 others. EMBO Rep, 2017. Cited by 94 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. Papers, record 28539390. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28539390

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.; PubMed
Journal: EMBO Rep; PubMed
Year: 2017; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/28539390/; PubMed
DOI: https://doi.org/10.15252/embr.201643827; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5887905/; PubMed
The journal: https://conductscience.org/library/journal-index/100963049; PubMed
Citations, by iCite: 94; iCite
Relative citation ratio, by iCite: 2.96; iCite
Revised in PubMed: 2021-05-26; PubMed

Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Mahdaviani K	Kiana
2	Benador IY	Ilan Y
3	Su S	Shi
4	Gharakhanian RA	Raffi A
5	Stiles L	Linsey
6	Trudeau KM	Kyle M
7	Cardamone M	Maria
8	Enríquez-Zarralanga V	Violeta
9	Ritou E	Eleni
10	Aprahamian T	Tamar

1 to 10 of 15Source PubMed

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Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adipose Tissue, Brown	Major topic
GTP Phosphohydrolases	Major topic
Insulin Resistance	Major topic
Thermogenesis	Major topic
Animals
Diet, High-Fat
Energy Metabolism
Female
Glycolysis
Male
Mice
Mitochondria
Mitochondrial Proteins
Obesity

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
T32 DK007201	NIDDK NIH HHS	United States	T32DK007201	PubMed and NIH	NIH RePORTER
S10 OD021652	NIH HHS	United States	S10OD021652	PubMed and NIH	NIH RePORTER
R01 DK100422	NIDDK NIH HHS	United States	R01DK100422	PubMed and NIH	NIH RePORTER
P30 DK046200	NIDDK NIH HHS	United States	P30DK046200	PubMed	NIH RePORTER
R01 DK099618	NIDDK NIH HHS	United States	R01DK099618	PubMed and NIH	NIH RePORTER
R01 DK056690	NIDDK NIH HHS	United States	R01DK056690	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	28,539,389	Let's burn whatever you have: mitofusin 2 metabolically re-wires brown adipose tissue.	https://conductscience.org/library/papers/28539389

Source PubMed

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	27,052,170	The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.	Cell Rep	2016	https://conductscience.org/library/papers/27052170	PubMed
2	23,791,483	Metabolic signaling in fuel-induced insulin secretion.	Cell Metab	2013	https://conductscience.org/library/papers/23791483	PubMed
3	19,187,776	UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.	Cell Metab	2009	https://conductscience.org/library/papers/19187776	PubMed
4	26,628,376	Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.	Cell Rep	2015	https://conductscience.org/library/papers/26628376	PubMed
5	23,562,075	Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.	Cell Metab	2013	https://conductscience.org/library/papers/23562075	PubMed
6	11,709,069	A history of UCP1.	Biochem Soc Trans	2001	https://conductscience.org/library/papers/11709069	PubMed
7	14,715,917	Brown adipose tissue: function and physiological significance.	Physiol Rev	2004	https://conductscience.org/library/papers/14715917	PubMed
8	24,431,221	Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.	EMBO J	2014	https://conductscience.org/library/papers/24431221	PubMed
9	21,258,337	Brown adipose tissue activity controls triglyceride clearance.	Nat Med	2011	https://conductscience.org/library/papers/21258337	PubMed
10	16,731,843	Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2.	Diabetes	2006	https://conductscience.org/library/papers/16731843	PubMed

1 to 10 of 24

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Cited by72

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 94 citations.

PMID	Title	Journal	Year	In Papers	Source
42,653,336	IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42653336	PubMed
42,521,674	Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.	Signal Transduct Target Ther	2026	https://conductscience.org/library/papers/42521674	PubMed
40,887,660	Molecular mechanisms of mitochondrial quality control.	Transl Neurodegener	2025	https://conductscience.org/library/papers/40887660	PubMed
40,750,944	2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction.	Nat Metab	2025	https://conductscience.org/library/papers/40750944	PubMed
40,444,323	Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2.	J Cell Sci	2025	https://conductscience.org/library/papers/40444323	PubMed
39,966,593	Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression.	Commun Biol	2025	https://conductscience.org/library/papers/39966593	PubMed
39,739,772	Loss of Mfn1 but not Mfn2 enhances adipogenesis.	PLoS One	2024	https://conductscience.org/library/papers/39739772	PubMed
39,652,536	Mitochondrial fission is required for thermogenesis in brown adipose tissue.	PLoS One	2024	https://conductscience.org/library/papers/39652536	PubMed
39,588,271	Molecular mechanisms of lipid droplets-mitochondria coupling in obesity and metabolic syndrome: insights and pharmacological implications.	Front Physiol	2024	https://conductscience.org/library/papers/39588271	PubMed
39,094,948	An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo.	Mol Metab	2024	https://conductscience.org/library/papers/39094948	PubMed

1 to 10 of 72

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
MFN2	9,927	PubTator's text mining	https://conductscience.org/library/genes/9927

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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