Paper · 14715917

Brown adipose tissue: function and physiological significance.

Cannon B and 1 other. Physiol Rev, 2004. Cited by 5,096 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Brown adipose tissue: function and physiological significance. Papers, record 14715917. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/14715917

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Brown adipose tissue: function and physiological significance.; PubMed
Journal: Physiol Rev; PubMed
Year: 2004; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/14715917/; PubMed
DOI: https://doi.org/10.1152/physrev.00015.2003; PubMed
The journal: https://conductscience.org/library/journal-index/0231714; PubMed
Citations, by iCite: 5,096; iCite
Relative citation ratio, by iCite: 119; iCite
Revised in PubMed: 2025-04-08; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Cannon B	Barbara
2	Nedergaard J	Jan

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adipose Tissue, Brown	Major topic
Signal Transduction	Major topic
Thermogenesis	Major topic
Animals
Humans
Norepinephrine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record	Source
NCT02499471	Brown Adipose Tissue Activity and Thyroid Hormone	Background		ClinicalTrials.gov
NCT03875625	Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention	Background		ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by3,115

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5,096 citations.

PMID	Title	Journal	Year	In Papers	Source
42,982,892	IDH2 links mitochondrial α-ketoglutarate to epigenetic thermogenic activation in brown adipose tissue.	Exp Mol Med	2026	https://conductscience.org/library/papers/42982892	PubMed
42,946,810	Beta-alanine provides partial protection against the development of symptoms driven by glucocorticoid excess.	Amino Acids	2026	https://conductscience.org/library/papers/42946810	PubMed
42,945,313	Imaging [18F]FDG PET/CT pilot study of nicotinic acetylcholinergic receptor α2 knock-out mice and α2 hypersensitive mice compared to control mice: Male-female differences and nicotine effects.	PLoS One	2026	https://conductscience.org/library/papers/42945313	PubMed
42,907,495	A futile Na+ K+ transport cycle augments energy expenditure in beige adipocytes.	Nat Metab	2026	https://conductscience.org/library/papers/42907495	PubMed
42,903,964	Mitochondrial flashes are interlinked with adaptive thermogenesis in brown adipocytes.	Hlife	2024	https://conductscience.org/library/papers/42903964	PubMed
42,893,232	Long-term voluntary exercise partially reverses obesity-associated transcriptomic remodeling in brown adipose tissue.	Metabol Open	2026	https://conductscience.org/library/papers/42893232	PubMed
42,875,491	Artificial intelligence-enabled clinical phenotyping of human brown fat.	Nature	2026	https://conductscience.org/library/papers/42875491	PubMed
42,874,135	VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.	J Physiol Sci	2026	https://conductscience.org/library/papers/42874135	PubMed
42,847,123	A nuclear ERK-ATF5 axis coordinates mitochondrial metabolism and thermogenic gene expression in brown adipocytes.	J Endocrinol	2026	https://conductscience.org/library/papers/42847123	PubMed
42,834,478	Meal-Induced Proton Density Fat Fraction and T 2 ∗ Decrease in Supraclavicular Adipose Tissue.	NMR Biomed	2026	https://conductscience.org/library/papers/42834478	PubMed

1 to 10 of 3,115

See all 3,115 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
LEP	3,952	PubTator's text mining	https://conductscience.org/library/genes/3952	NCBI Gene
UCP1	7,350	PubTator's text mining	https://conductscience.org/library/genes/7350	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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