Paper · 42907495

A futile Na+ K+ transport cycle augments energy expenditure in beige adipocytes.

Liu Q and 30 others. Nat Metab, 2026.

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ConductScience Library. A futile Na+ K+ transport cycle augments energy expenditure in beige adipocytes. Papers, record 42907495. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42907495

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Paper

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Title: A futile Na+ K+ transport cycle augments energy expenditure in beige adipocytes.
Journal: Nat Metab
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42907495/
DOI: https://doi.org/10.1038/s42255-026-01630-9
The journal: https://conductscience.org/library/journal-index/101736592
Revised in PubMed: 2026-10-31

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Authors31

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Liu Q	Qing
2	Cheng Y	Ying
3	Yan D	Dandan
4	Wu W	Wenjie
5	Lei Z	Zhenchuan
6	Long Q	Qiaoyun
7	Zhao Z	Ziyu
8	Gao Y	Yuan
9	Wang B	Baile
10	Feng T	Tianshi

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Topics0

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Grants1

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Grant, as the record writes it	Agency	Country	NIH project	Stated by
82325010	National Natural Science Foundation of China (National Science Foundation of China)			PubMed

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Trials0

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None in this release.

Comments and corrections1

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Kind	PMID	Title	In Papers
Erratum in	42,957,884	Publisher Correction: A futile Na+ K+ transport cycle augments energy expenditure in beige adipocytes.	https://conductscience.org/library/papers/42957884

Source PubMed

References43

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	14,715,917	Brown adipose tissue: function and physiological significance.	Physiol Rev	2004	https://conductscience.org/library/papers/14715917	PubMed
2	16,914,547	UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice.	J Biol Chem	2006	https://conductscience.org/library/papers/16914547	PubMed
3	19,357,406	Identification and importance of brown adipose tissue in adult humans.	N Engl J Med	2009	https://conductscience.org/library/papers/19357406	PubMed
4	19,357,405	Cold-activated brown adipose tissue in healthy men.	N Engl J Med	2009	https://conductscience.org/library/papers/19357405	PubMed
5	19,357,407	Functional brown adipose tissue in healthy adults.	N Engl J Med	2009	https://conductscience.org/library/papers/19357407	PubMed
6	35,296,864	A single-cell atlas of human and mouse white adipose tissue.	Nature	2022	https://conductscience.org/library/papers/35296864	PubMed
7	39,084,217	Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.	Cell Metab	2024	https://conductscience.org/library/papers/39084217	PubMed
8	39,084,216	Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.	Cell Metab	2024	https://conductscience.org/library/papers/39084216	PubMed
9	26,496,606	A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.	Cell	2015	https://conductscience.org/library/papers/26496606	PubMed
10	29,131,158	UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.	Nat Med	2017	https://conductscience.org/library/papers/29131158	PubMed

1 to 10 of 43

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Cited by0

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Genes0

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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