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Paper · 3446554

Pancreatic and intestinal processing of proglucagon in man.

Orskov C and 3 others. Diabetologia, 1987. Cited by 189 papers, by iCite.

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ConductScience Library. Pancreatic and intestinal processing of proglucagon in man. Papers, record 3446554. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3446554

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Pancreatic and intestinal processing of proglucagon in man.
PubMed
Journal
Diabetologia
PubMed
Year
1987
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
189
iCite
Relative citation ratio, by iCite
5.35
iCite
Revised in PubMed
2019-08-16
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Orskov CC
2Holst JJJ J
3Poulsen SSS S
4Kirkegaard PP

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gastrointestinal HormonesMajor topic
GlucagonMajor topic
Intestine, SmallMajor topic
PancreasMajor topic
Pancreatic HormonesMajor topic
PeptidesMajor topic
Protein PrecursorsMajor topic
Adult
Amino Acid Sequence
Chromatography, Gel
Chromatography, High Pressure Liquid
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Humans
Ileum
Proglucagon
Radioimmunoassay

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,546,922Glucagon-related peptides in the human gastrointestinal mucosa.Diabetologia1984https://conductscience.org/library/papers/6546922PubMed
23,542,566Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut.FEBS Lett1987https://conductscience.org/library/papers/3542566PubMed
33,530,719Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas.Endocrinology1986https://conductscience.org/library/papers/3530719PubMed
46,382,256Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6382256PubMed
56,397,386How glucagon-like is glucagon-like peptide-1?Diabetologia1984https://conductscience.org/library/papers/6397386PubMed
63,543,057Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.J Clin Invest1987https://conductscience.org/library/papers/3543057PubMed
714,392Preparation of 125I-labeled synthetic porcine secretin for radioimmunoassay.Scand J Clin Lab Invest1976https://conductscience.org/library/papers/14392PubMed
83,528,148Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.J Biol Chem1986https://conductscience.org/library/papers/3528148PubMed
93,905,480Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets.Diabetologia1985https://conductscience.org/library/papers/3905480PubMed
103,840,748Molecular forms of glucagon-like peptides in man.FEBS Lett1985https://conductscience.org/library/papers/3840748PubMed

1 to 10 of 20

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Cited by53

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 189 citations.

PMIDTitleJournalYearIn PapersSource
41,561,058Research progress in precision medicine for type 2 diabetes based on the GLP-1.Front Endocrinol (Lausanne)2025https://conductscience.org/library/papers/41561058PubMed
41,106,391Predictive prioritization of enhancers associated with pancreatic disease risk.Cell Genom2026https://conductscience.org/library/papers/41106391PubMed
40,896,289Current understanding and controversy on brain access of GLP-1 and GLP-1 receptor agonists.J Transl Int Med2025https://conductscience.org/library/papers/40896289PubMed
39,114,288Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists.Front Endocrinol (Lausanne)2024https://conductscience.org/library/papers/39114288PubMed
35,629,924The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion.Metabolites2022https://conductscience.org/library/papers/35629924PubMed
34,168,620What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?Front Endocrinol (Lausanne)2021https://conductscience.org/library/papers/34168620PubMed
34,093,449Proglucagon-Derived Peptides as Therapeutics.Front Endocrinol (Lausanne)2021https://conductscience.org/library/papers/34093449PubMed
33,480,865Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans.Endocr Connect2021https://conductscience.org/library/papers/33480865PubMed
33,432,200Metabolic Messengers: glucagon-like peptide 1.Nat Metab2021https://conductscience.org/library/papers/33432200PubMed
32,937,194Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.Mol Metab2020https://conductscience.org/library/papers/32937194PubMed

1 to 10 of 53

See all 53 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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