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Paper · 35239441

Dual-function Spot 42 RNA encodes a 15-amino acid protein that regulates the CRP transcription factor.

Aoyama JJ and 3 others. Proc Natl Acad Sci U S A, 2022. Cited by 41 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Dual-function Spot 42 RNA encodes a 15-amino acid protein that regulates the CRP transcription factor. Papers, record 35239441. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35239441

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Dual-function Spot 42 RNA encodes a 15-amino acid protein that regulates the CRP transcription factor.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
3.14
iCite
Revised in PubMed
2025-05-30
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Aoyama JJJordan J
2Raina MMedha
3Zhong AAoshu
4Storz GGiselahttps://orcid.org/0000-0001-6698-1241

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Amino AcidsMajor topic
Escherichia coli ProteinsMajor topic
RNA, BacterialMajor topic
RNA, Small UntranslatedMajor topic
Transcription FactorsMajor topic
Base Pairing
Escherichia coli
Glucose
Histidine
Operon
Promoter Regions, Genetic
Protein Binding
Temperature

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
ZIA HD001608Intramural NIH HHSUnited StatesZIAHD001608PubMed and NIHNIH RePORTER
ZIA HD008855Intramural NIH HHSUnited StatesZIAHD008855PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,148,987Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli.J Am Chem Soc2002https://conductscience.org/library/papers/12148987PubMed
226,327,359The Spot 42 RNA: A regulatory small RNA with roles in the central metabolism.RNA Biol2015https://conductscience.org/library/papers/26327359PubMed
328,289,085The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System.J Bacteriol2017https://conductscience.org/library/papers/28289085PubMed
410,550,204Transcription activation by catabolite activator protein (CAP).J Mol Biol1999https://conductscience.org/library/papers/10550204PubMed
521,292,161The base-pairing RNA spot 42 participates in a multioutput feedforward loop to help enact catabolite repression in Escherichia coli.Mol Cell2011https://conductscience.org/library/papers/21292161PubMed
622,388,518Multiple factors dictate target selection by Hfq-binding small RNAs.EMBO J2012https://conductscience.org/library/papers/22388518PubMed
730,837,344Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes.mBio2019https://conductscience.org/library/papers/30837344PubMed
818,978,044The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior.J Bacteriol2009https://conductscience.org/library/papers/18978044PubMed
919,033,675cAMP receptor protein from escherichia coli as a model of signal transduction in proteins--a review.J Mol Microbiol Biotechnol2009https://conductscience.org/library/papers/19033675PubMed
10390,161A small, unstable RNA molecule of Escherichia coli: spot 42 RNA. I. Nucleotide sequence analysis.J Mol Biol1979https://conductscience.org/library/papers/390161PubMed

1 to 10 of 37

See all 37 references

Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
42,618,766Bacterial small regulatory RNAs.Nat Rev Microbiol2026https://conductscience.org/library/papers/42618766PubMed
42,606,387From environmental signals to adaptive phenotypes: signal-responsive regulation and network logic of bacterial small RNAs.FEMS Microbiol Rev2026https://conductscience.org/library/papers/42606387PubMed
41,562,254YhfH functions as a tri-function RNA in Bacillus thuringiensis BMB171.Nucleic Acids Res2026https://conductscience.org/library/papers/41562254PubMed
41,385,328De novo origin of numerous microproteins in enterobacteria.Nucleic Acids Res2025https://conductscience.org/library/papers/41385328PubMed
41,313,722De Novo Genes: Current Status and Future Goals.Genome Biol Evol2025https://conductscience.org/library/papers/41313722PubMed
41,246,142One transcript, two functions: the emerging roles of dual-function RNAs.Microlife2025https://conductscience.org/library/papers/41246142PubMed
40,920,071Investigation of the global translational response to oxidative stress in the model archaeon Haloferax volcanii reveals untranslated small RNAs with ribosome occupancy.mSphere2025https://conductscience.org/library/papers/40920071PubMed
40,741,359Overview of small proteins encoded by bacterial dual-function small RNAs.Noncoding RNA Res2025https://conductscience.org/library/papers/40741359PubMed
40,725,121Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs.Int J Mol Sci2025https://conductscience.org/library/papers/40725121PubMed
40,444,151Advances in sRNA-mediated regulation of Salmonella infection in the host.Front Cell Infect Microbiol2025https://conductscience.org/library/papers/40444151PubMed

1 to 10 of 31

See all 31 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CRP1,401PubTator's text mininghttps://conductscience.org/library/genes/1401NCBI Gene
GALK12,584PubTator's text mininghttps://conductscience.org/library/genes/2584NCBI Gene
KLKB13,818PubTator's text mininghttps://conductscience.org/library/genes/3818NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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