Paper · 3540600

Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.

Schatz PJ and 2 others. Mol Cell Biol, 1986. Cited by 200 papers, by iCite.

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ConductScience Library. Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Papers, record 3540600. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3540600

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.; PubMed
Journal: Mol Cell Biol; PubMed
Year: 1986; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3540600/; PubMed
DOI: https://doi.org/10.1128/mcb.6.11.3722-3733.1986; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC367133/; PubMed
The journal: https://conductscience.org/library/journal-index/8109087; PubMed
Citations, by iCite: 200; iCite
Relative citation ratio, by iCite: 3.54; iCite
Revised in PubMed: 2021-05-26; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Schatz PJ	P J
2	Solomon F	F
3	Botstein D	D

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Genes	Major topic
Genes, Fungal	Major topic
Saccharomyces cerevisiae	Major topic
Tubulin	Major topic
Alleles
Chromosome Mapping
Crosses, Genetic
Genetic Complementation Test
Genetic Linkage
Genotype
Plasmids
Suppression, Genetic

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
GM-18973	NIGMS NIH HHS	United States		PubMed	PubMed
GM-21253	NIGMS NIH HHS	United States	R01GM021253	PubMed and NIH	NIH RePORTER
P01-CA-26712	NCI NIH HHS	United States	P01CA026712	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References55

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,397,403	Molecular cloning of the GAL80 gene from Saccharomyces cerevisiae and characterization of a gal80 deletion.	Gene	1984	https://conductscience.org/library/papers/6397403	PubMed
2	6,393,054	Nucleotide sequence of the yeast regulatory gene GAL80.	Nucleic Acids Res	1984	https://conductscience.org/library/papers/6393054	PubMed
3	3,896,122	Molecular biology and genetics of tubulin.	Annu Rev Biochem	1985	https://conductscience.org/library/papers/3896122	PubMed
4	3,897,246	Involvement of a particular species of beta-tubulin (beta 3) in conidial development in Aspergillus nidulans.	J Cell Biol	1985	https://conductscience.org/library/papers/3897246	PubMed
5	3,897,247	Identification and functional analysis of beta-tubulin genes by site specific integrative transformation in Aspergillus nidulans.	J Cell Biol	1985	https://conductscience.org/library/papers/3897247	PubMed
6	3,900,413	Transformation of yeast with linearized plasmid DNA. Formation of inverted dimers and recombinant plasmid products.	J Mol Biol	1985	https://conductscience.org/library/papers/3900413	PubMed
7	2,995,780	Genetic map of Saccharomyces cerevisiae, edition 9.	Microbiol Rev	1985	https://conductscience.org/library/papers/2995780	PubMed
8	2,998,923	Isolation and characterization of mutations in the beta-tubulin gene of Saccharomyces cerevisiae.	Genetics	1985	https://conductscience.org/library/papers/2998923	PubMed
9	5,097,530	A stable aneuploid of Saccharomyces cerevisiae.	Genetics	1971	https://conductscience.org/library/papers/5097530	PubMed
10	1,195,397	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	J Mol Biol	1975	https://conductscience.org/library/papers/1195397	PubMed

1 to 10 of 55

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Cited by120

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 200 citations.

PMID	Title	Journal	Year	In Papers	Source
42,920,701	Functional redundancy and synthetic haploinsufficiency among Arabidopsis ATP-citrate lyase genes.	Front Plant Sci	2026	https://conductscience.org/library/papers/42920701	PubMed
41,965,830	Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes.	EMBO Rep	2026	https://conductscience.org/library/papers/41965830	PubMed
41,191,558	αβ-tubulin heterodimers: Origins and regulation of microtubule building blocks.	Mol Biol Cell	2026	https://conductscience.org/library/papers/41191558	PubMed
38,527,106	A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit.	Elife	2024	https://conductscience.org/library/papers/38527106	PubMed
36,719,400	Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin.	J Cell Biol	2023	https://conductscience.org/library/papers/36719400	PubMed
36,190,134	ALIBY: ALFA Nanobody-Based Toolkit for Imaging and Biochemistry in Yeast.	mSphere	2022	https://conductscience.org/library/papers/36190134	PubMed
35,865,635	Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions.	Front Cell Dev Biol	2022	https://conductscience.org/library/papers/35865635	PubMed
34,849,907	Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.	Genetics	2021	https://conductscience.org/library/papers/34849907	PubMed
34,762,120	Specialist α-tubulins for pluralist microtubules.	J Cell Biol	2021	https://conductscience.org/library/papers/34762120	PubMed
34,739,032	Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis.	J Cell Biol	2021	https://conductscience.org/library/papers/34739032	PubMed

1 to 10 of 120

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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