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Paper · 37540118

An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.

Flajnik MF and 5 others. J Immunol, 2023. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG. Papers, record 37540118. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37540118

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.
PubMed
Journal
J Immunol
PubMed
Year
2023
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
0.55
iCite
Revised in PubMed
2025-08-01
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Flajnik MFMartin Fhttps://orcid.org/0000-0002-2792-5084
2Stanfield RRobynhttps://orcid.org/0000-0001-9521-9184
3Pokidysheva ENElena Nhttps://orcid.org/0000-0001-6167-6678
4Boudko SPSergei P
5Wilson IIanhttps://orcid.org/0000-0002-6469-2419
6Ohta YYukohttps://orcid.org/0000-0002-2348-9107

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
SharksMajor topic
AntibodiesMajor topic
Major Histocompatibility ComplexMajor topic
Immunoglobulin G
Phylogeny
Evolution, Molecular
Amino Acid Sequence
Sequence Alignment
Liver
Gene Expression
Mammals
Organ Specificity

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AI140326NIAID NIH HHSUnited StatesR01AI140326PubMed and NIHNIH RePORTER
R01 AI170844NIAID NIH HHSUnited StatesR01AI170844PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
13,043,226T-cell antigen receptor genes and T-cell recognition.Nature1988https://conductscience.org/library/papers/3043226PubMed
225,114,105The proto-MHC of placozoans, a region specialized in cellular stress and ubiquitination/proteasome pathways.J Immunol2014https://conductscience.org/library/papers/25114105PubMed
334,981,186On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics2022https://conductscience.org/library/papers/34981186PubMed
433,449,123Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks.Immunogenetics2021https://conductscience.org/library/papers/33449123PubMed
519,404,636Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates.Immunogenetics2009https://conductscience.org/library/papers/19404636PubMed
610,811,858Rearrangement of immunoglobulin genes in shark germ cells.J Exp Med2000https://conductscience.org/library/papers/10811858PubMed
716,549,799An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks.Proc Natl Acad Sci U S A2006https://conductscience.org/library/papers/16549799PubMed
827,362,646Emergence and Evolution of Secondary Lymphoid Organs.Annu Rev Cell Dev Biol2016https://conductscience.org/library/papers/27362646PubMed
929,677,478Unfinished Business: Evolution of the MHC and the Adaptive Immune System of Jawed Vertebrates.Annu Rev Immunol2018https://conductscience.org/library/papers/29677478PubMed
1029,722,887MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.Mol Biol Evol2018https://conductscience.org/library/papers/29722887PubMed

1 to 10 of 61

See all 61 references

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
40,614,193Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.Sci Adv2025https://conductscience.org/library/papers/40614193PubMed
40,503,440The staphylococcal collagen adhesin CNA35 effectively detects collagen and its fragments in blots after SDS-PAGE.Matrix Biol Plus2025https://conductscience.org/library/papers/40503440PubMed
39,317,775Understanding vertebrate immunity through comparative immunology.Nat Rev Immunol2025https://conductscience.org/library/papers/39317775PubMed
39,223,989The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunol Rev2024https://conductscience.org/library/papers/39223989PubMed
38,059,517An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.Mol Biol Evol2023https://conductscience.org/library/papers/38059517PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
HLA-C3,107PubTator's text mininghttps://conductscience.org/library/genes/3107NCBI Gene
TRBV20OR9-26,962PubTator's text mininghttps://conductscience.org/library/genes/6962NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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