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Paper38515134

CTLs heterogeneity and plasticity: implications for cancer immunotherapy.

Peng S and 7 others. Mol Cancer, 2024. Cited by 102 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. CTLs heterogeneity and plasticity: implications for cancer immunotherapy. Papers, record 38515134. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/38515134

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
CTLs heterogeneity and plasticity: implications for cancer immunotherapy.
PubMed
Journal
Mol Cancer
PubMed
Year
2024
PubMed
Publication types
Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
102
iCite
Relative citation ratio, by iCite
12.22, provisional
iCite
Revised in PubMed
2024-04-03
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Peng SShengkun
2Lin AAnqi
3Jiang AAimin
4Zhang CCangang
5Zhang JJian
6Cheng QQuan
7Luo PPeng
8Bai YYifeng

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
T-Lymphocytes, CytotoxicMajor topic
NeoplasmsMajor topic
Humans
Epigenesis, Genetic
Immunotherapy
Biomarkers

Source PubMed

References163

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
136,636,719The oral cancer microbiome contains tumor space-specific and clinicopathology-specific bacteria.Front Cell Infect Microbiol2022https://conductscience.org/library/papers/36636719PubMed
224,586,481Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells.PLoS One2014https://conductscience.org/library/papers/24586481PubMed
325,387,013Comparative biology of γδ T cell function in humans, mice, and domestic animals.Annu Rev Anim Biosci2013https://conductscience.org/library/papers/25387013PubMed
435,572,552The Era of Cytotoxic CD4 T Cells.Front Immunol2022https://conductscience.org/library/papers/35572552PubMed
533,526,861EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia.Leukemia2021https://conductscience.org/library/papers/33526861PubMed
634,681,881Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment.Int J Mol Sci2021https://conductscience.org/library/papers/34681881PubMed
735,086,948CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model.J Immunother Cancer2022https://conductscience.org/library/papers/35086948PubMed
836,599,469Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis.J Immunother Cancer2023https://conductscience.org/library/papers/36599469PubMed
927,670,945Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.Innate Immun2016https://conductscience.org/library/papers/27670945PubMed
1028,709,825The Ambiguous Role of γδ T Lymphocytes in Antitumor Immunity.Trends Immunol2017https://conductscience.org/library/papers/28709825PubMed
1137,202,206Murine cytotoxic CD4+ T cells in the tumor microenvironment are at a hyper-maturation stage of Th1 CD4+ T cells sustained by IL-12.Int Immunol2023https://conductscience.org/library/papers/37202206PubMed
1219,904,767Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis.Eur J Immunol2010https://conductscience.org/library/papers/19904767PubMed
1336,937,426Modulating the proliferative and cytotoxic properties of patient-derived TIL by a synthetic immune niche of immobilized CCL21 and ICAM1.Front Oncol2023https://conductscience.org/library/papers/36937426PubMed
142,022,921Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.J Exp Med1991https://conductscience.org/library/papers/2022921PubMed
1518,219,309Shaping and reshaping CD8+ T-cell memory.Nat Rev Immunol2008https://conductscience.org/library/papers/18219309PubMed
1627,809,856T cells in multiple myeloma display features of exhaustion and senescence at the tumor site.J Hematol Oncol2016https://conductscience.org/library/papers/27809856PubMed
1732,870,971The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.Blood Adv2020https://conductscience.org/library/papers/32870971PubMed
1828,898,397Genome-wide DNA methylation analysis of senescence in repetitively infected memory cytotoxic T lymphocytes.Immunology2018https://conductscience.org/library/papers/28898397PubMed
1936,796,366OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.Cell Rep Med2023https://conductscience.org/library/papers/36796366PubMed
2015,556,688The characteristics of human NKT cells in lung cancer--CD1d independent cytotoxicity against lung cancer cells by NKT cells and decreased human NKT cell response in lung cancer patients.Hum Immunol2004https://conductscience.org/library/papers/15556688PubMed

See all 163 references

Cited by78

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 102 citations.

PMIDTitleJournalYearIn PapersSource
42,982,946Pulsed Low-dose-rate Radiotherapy Remodels the Tumor Immune Microenvironment and is Associated With Crosstalk Between SPP1⁺ tumor-associated macrophages and GZMK⁺ CD8⁺ T cells.Cell Biol Toxicol2026https://conductscience.org/library/papers/42982946PubMed
42,979,333Targeting cancer-associated neutrophils with biomimetic nano-vaccines loaded with mRNA can enhance the efficacy of immunotherapy for hepatocellular carcinoma.Acta Pharm Sin B2026https://conductscience.org/library/papers/42979333PubMed
42,724,447Global research trends in fecal microbiota transplantation combined with immune checkpoint inhibitors for cancer immunotherapy: a bibliometric analysis.Transl Cancer Res2026https://conductscience.org/library/papers/42724447PubMed
42,538,571Fatty acid metabolism in glioma: a review of novel targets and therapeutic strategies.Chin Neurosurg J2026https://conductscience.org/library/papers/42538571PubMed
42,523,842Immune-epigenetic-metabolic crosstalk: attempting to unravel the multidimensional mechanisms of immune evasion in endometriosis.Front Immunol2026https://conductscience.org/library/papers/42523842PubMed
42,388,313Research progress on T-cell responses in Staphylococcus aureus infections.Front Microbiol2026https://conductscience.org/library/papers/42388313PubMed
42,304,928Exploring the Tumor Microenvironment: Immuno-Genotoxic Biomarkers at the Forefront of Cancer Diagnosis and Therapy.Curr Cancer Drug Targets2026https://conductscience.org/library/papers/42304928PubMed
42,266,746BANF1 knockdown impedes thyroid cancer development and boosts CD8+ T cell activity through PI3K/AKT/mTOR pathway.Am J Cancer Res2026https://conductscience.org/library/papers/42266746PubMed
42,221,415Glucagon-like Peptide-1 Receptor Agonists and Colorectal Cancer Risk.AACE Endocrinol Diabetes2026https://conductscience.org/library/papers/42221415PubMed
42,151,232Nanoplastics impair antitumor NK and CD8⁺ T cell cytotoxicity and antiviral B cell antibody responses to SARS-CoV-2.Sci Rep2026https://conductscience.org/library/papers/42151232PubMed
42,105,153Precision oncology in gastric cancer: navigating molecular subtypes, therapeutic targets, and future horizons.Cell Oncol (Dordr)2026https://conductscience.org/library/papers/42105153PubMed
42,103,355LGALS9 blockade augments vaccine-induced immune responses against prostate cancer.J Immunother Cancer2026https://conductscience.org/library/papers/42103355PubMed
41,956,548Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management.Hum Vaccin Immunother2026https://conductscience.org/library/papers/41956548PubMed
41,854,744Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.J Mol Med (Berl)2026https://conductscience.org/library/papers/41854744PubMed
41,803,090Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets.Signal Transduct Target Ther2026https://conductscience.org/library/papers/41803090PubMed
41,766,862Beyond the Th2 paradigm: CD4+ cytotoxic T lymphocytes as key drivers of tissue damage and fibrosis in IgG4-related disease.Front Immunol2026https://conductscience.org/library/papers/41766862PubMed
41,738,042Temporal dynamics in cancer immunotherapy: the interplay between circadian rhythms, tumor microenvironment, and immune checkpoint blockade.J Natl Cancer Cent2026https://conductscience.org/library/papers/41738042PubMed
41,681,793BCL2A1high CD8+ T Cells Are a Survival-Associated Predictor of Immune Checkpoint Blockade Response in Lung Adenocarcinoma.Diagnostics (Basel)2026https://conductscience.org/library/papers/41681793PubMed
41,664,229Semaphorins: from CD8⁺ T cells to cancer immunotherapy.Biomark Res2026https://conductscience.org/library/papers/41664229PubMed
41,625,477Tumor Microenvironment Onmyoji: Cytokines with Dual Protumor and Antitumor Roles.Cancer Commun (Lond)2026https://conductscience.org/library/papers/41625477PubMed

See all 78 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
PRDM1639PubTator's text mininghttps://conductscience.org/library/genes/639NCBI Gene
TBX2130,009PubTator's text mininghttps://conductscience.org/library/genes/30009NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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