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Paper · 3896232

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.

Heyworth CM and 4 others. Biochem J, 1985. Cited by 87 papers, by iCite.

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ConductScience Library. Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes. Papers, record 3896232. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3896232

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.
PubMed
Journal
Biochem J
PubMed
Year
1985
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
87
iCite
Relative citation ratio, by iCite
2.2
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Heyworth CMC M
2Whetton ADA D
3Wong SS
4Martin BRB R
5Houslay MDM D

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cholera ToxinMajor topic
InsulinMajor topic
LiverMajor topic
Membrane ProteinsMajor topic
Animals
Cell Fractionation
Cell Membrane
Electrophoresis, Polyacrylamide Gel
Male
Rats
Rats, Inbred Strains
Tetradecanoylphorbol Acetate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References65

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
13,883,992Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.Biochem J1985https://conductscience.org/library/papers/3883992PubMed
26,269,936A partial view of the mechanism of insulin action.Diabetologia1981https://conductscience.org/library/papers/6269936PubMed
36,118,145Cholera toxin modifies diverse GTP-modulated regulatory proteins.Biochem Biophys Res Commun1981https://conductscience.org/library/papers/6118145PubMed
46,276,4413,3',5-triiodothyronine administration in vivo modulates the hormone-sensitive adenylate cyclase system of rat hepatocytes.J Clin Invest1982https://conductscience.org/library/papers/6276441PubMed
56,277,948Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.J Biol Chem1982https://conductscience.org/library/papers/6277948PubMed
66,125,514Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.J Biol Chem1982https://conductscience.org/library/papers/6125514PubMed
76,757,248Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.J Biol Chem1982https://conductscience.org/library/papers/6757248PubMed
86,296,122Identification of the predominant substrate for ADP-ribosylation by islet activating protein.J Biol Chem1983https://conductscience.org/library/papers/6296122PubMed
96,299,798Guanine nucleotides can activate the insulin-stimulated phosphodiesterase in liver plasma membranes.FEBS Lett1983https://conductscience.org/library/papers/6299798PubMed
106,300,694Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins.Nature1983https://conductscience.org/library/papers/6300694PubMed

1 to 10 of 65

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Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 87 citations.

PMIDTitleJournalYearIn PapersSource
8,280,104Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.Biochem J1994https://conductscience.org/library/papers/8280104PubMed
8,010,967Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).Biochem J1994https://conductscience.org/library/papers/8010967PubMed
3,936,483Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein.Biochem J1985https://conductscience.org/library/papers/3936483PubMed
3,521,589Evidence that insulin and guanosine triphosphate regulate dephosphorylation of the beta-subunit of the insulin receptor in sarcolemma membranes isolated from skeletal muscle.Biochem J1986https://conductscience.org/library/papers/3521589PubMed
3,124,829
Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.
Biochem J1988https://conductscience.org/library/papers/3124829PubMed
3,117,049Detection of 23-27 kDa GTP-binding proteins in platelets and other cells.Biochem J1987https://conductscience.org/library/papers/3117049PubMed
3,099,763Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.Biochem J1986https://conductscience.org/library/papers/3099763PubMed
3,099,281Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3099281PubMed
3,066,348Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells.Biochem J1988https://conductscience.org/library/papers/3066348PubMed
3,017,298The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.Biochem J1986https://conductscience.org/library/papers/3017298PubMed

1 to 10 of 23

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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