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Paper · 3883992

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.

van de Werve G and 2 others. Biochem J, 1985. Cited by 80 papers, by iCite.

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ConductScience Library. Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding. Papers, record 3883992. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3883992

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.
PubMed
Journal
Biochem J
PubMed
Year
1985
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
80
iCite
Relative citation ratio, by iCite
2.34
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1van de Werve GG
2Proietto JJ
3Jeanrenaud BB

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adipose TissueMajor topic
InsulinMajor topic
LipidsMajor topic
Phorbol EstersMajor topic
PhorbolsMajor topic
Animals
Dose-Response Relationship, Drug
In Vitro Techniques
Male
Rats
Rats, Inbred Strains
Tetradecanoylphorbol Acetate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1312,103Inhibition of epidermal growth factor binding to surface receptors by tumor promotors.Biochem Biophys Res Commun1979https://conductscience.org/library/papers/312103PubMed
26,891,320Inhibition of insulin receptor binding by phorbol esters.Eur J Biochem1982https://conductscience.org/library/papers/6891320PubMed
34,819,286A simple free fat cell bioassay for insulin.Horm Metab Res1974https://conductscience.org/library/papers/4819286PubMed
46,378,690Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase.Mol Cell Endocrinol1984https://conductscience.org/library/papers/6378690PubMed
54,433,545The effect of insulin on 32Pi incorporation into rat fat cell phospholipids.Biochim Biophys Acta1974https://conductscience.org/library/papers/4433545PubMed
66,411,068Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents.Biochem J1983https://conductscience.org/library/papers/6411068PubMed
76,329,860
The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase.
Diabetes1984https://conductscience.org/library/papers/6329860PubMed
86,249,261Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cells.Biochem J1980https://conductscience.org/library/papers/6249261PubMed
97,085,651Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.J Biol Chem1982https://conductscience.org/library/papers/7085651PubMed
104,289,986The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue.Biochim Biophys Acta1966https://conductscience.org/library/papers/4289986PubMed

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Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.

PMIDTitleJournalYearIn PapersSource
8,380,998Insulin-mimetic actions of phorbol ester in cultured adult rat hepatocytes. Lack of phorbol-ester-elicited inhibition of the insulin signal.Biochem J1993https://conductscience.org/library/papers/8380998PubMed
7,980,440Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression.Biochem J1994https://conductscience.org/library/papers/7980440PubMed
3,935,104Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes.Biochem J1985https://conductscience.org/library/papers/3935104PubMed
3,896,232Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.Biochem J1985https://conductscience.org/library/papers/3896232PubMed
3,540,941Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3540941PubMed
3,526,339Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3526339PubMed
3,297,041Stimulation of adipocyte phospholipid methyltransferase activity by phorbol 12-myristate 13-acetate. Differential regulation of phospholipid methyltransferase and lipolysis.Biochem J1987https://conductscience.org/library/papers/3297041PubMed
3,281,656Phorbol esters imitate in rat fat-cells the full effect of insulin on glucose-carrier translocation, but not on 3-O-methylglucose-transport activity.Biochem J1988https://conductscience.org/library/papers/3281656PubMed
3,280,335Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells.Experientia1988https://conductscience.org/library/papers/3280335PubMed
3,024,623Stimulation of phosphoinositide metabolism in hamster brown adipocytes exposed to alpha 1-adrenergic agents and its inhibition with phorbol esters.Biochem J1986https://conductscience.org/library/papers/3024623PubMed

1 to 10 of 18

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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