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Paper · 3540941

Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.

Stumpo DJ and 1 other. Proc Natl Acad Sci U S A, 1986. Cited by 173 papers, by iCite.

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ConductScience Library. Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes. Papers, record 3540941. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3540941

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1986
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
173
iCite
Relative citation ratio, by iCite
3.77
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stumpo DJD J
2Blackshear PJP J

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Growth SubstancesMajor topic
InsulinMajor topic
Proto-Oncogene ProteinsMajor topic
Proto-OncogenesMajor topic
Adipose Tissue
Animals
Cycloheximide
Fibroblasts
Gene Expression Regulation
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Mice
Protein Kinase C
RNA, Messenger
Tetradecanoylphorbol Acetate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References63

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,981Mechanisms and regulation of biosynthesis of saturated fatty acids.Physiol Rev1976https://conductscience.org/library/papers/6981PubMed
23,080,420Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.J Biol Chem1986https://conductscience.org/library/papers/3080420PubMed
3303,773Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/303773PubMed
481,205Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells.J Biol Chem1978https://conductscience.org/library/papers/81205PubMed
5436,783Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts.Endocrinology1979https://conductscience.org/library/papers/436783PubMed
67,016,879Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.J Biol Chem1981https://conductscience.org/library/papers/7016879PubMed
76,166,044Pancreatic islet-acinar cell interaction: amylase messenger RNA levels ar determined by insulin.Science1981https://conductscience.org/library/papers/6166044PubMed
83,080,427
Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.
J Biol Chem1986https://conductscience.org/library/papers/3080427PubMed
93,005,046EGF and insulin action in fibroblasts. Evidence that phosphoinositide hydrolysis is not an essential mitogenic signalling pathway.FEBS Lett1986https://conductscience.org/library/papers/3005046PubMed
103,081,899Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3081899PubMed

1 to 10 of 63

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Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 173 citations.

PMIDTitleJournalYearIn PapersSource
35,213,968Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach.Pharmaceutics2022https://conductscience.org/library/papers/35213968PubMed
34,020,084Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.Mol Metab2021https://conductscience.org/library/papers/34020084PubMed
31,244,519Signaling from Neural Impulses to Genes.Neuroscientist1996https://conductscience.org/library/papers/31244519PubMed
21,689,613Insulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma.Clin Liver Dis2011https://conductscience.org/library/papers/21689613PubMed
17,030,620Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts.Mol Cell Biol2006https://conductscience.org/library/papers/17030620PubMed
11,988,078A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation.Biochem J2002https://conductscience.org/library/papers/11988078PubMed
9,549,046Insulin induction of pip 92, CL-6, and novel mRNAs in rat hepatoma cells.Endocrine1997https://conductscience.org/library/papers/9549046PubMed
9,092,589Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2.J Neurosci1997https://conductscience.org/library/papers/9092589PubMed
8,717,436Expression of c-Fos in subcutaneous adipose tissue of the fetal pig.Mol Cell Biochem1996https://conductscience.org/library/papers/8717436PubMed
8,513,338Expression of c-fos and c-myc protooncogenes in an immortalized hepatocyte line harbouring SV40 T antigen and hGH as transgenes.Transgenic Res1993https://conductscience.org/library/papers/8513338PubMed

1 to 10 of 29

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
FOS2,353PubTator's text mininghttps://conductscience.org/library/genes/2353NCBI Gene
GRP2,922PubTator's text mininghttps://conductscience.org/library/genes/2922NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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