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Paper · 3932050

Healing of benign gastric ulcer. A placebo-controlled comparison of two dosage regimens of misoprostol, a synthetic analog of prostaglandin E1.

Agrawal NM and 4 others. Dig Dis Sci, 1985. Cited by 64 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Healing of benign gastric ulcer. A placebo-controlled comparison of two dosage regimens of misoprostol, a synthetic analog of prostaglandin E1. Papers, record 3932050. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3932050

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Healing of benign gastric ulcer. A placebo-controlled comparison of two dosage regimens of misoprostol, a synthetic analog of prostaglandin E1.
PubMed
Journal
Dig Dis Sci
PubMed
Year
1985
PubMed
Publication types
Clinical Trial, Journal Article, Randomized Controlled Trial
PubMed
Citations, by iCite
64
iCite
Relative citation ratio, by iCite
3.91
iCite
Revised in PubMed
2019-07-21
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Agrawal NMN M
2Saffouri BB
3Kruss DMD M
4Callison DAD A
5Dajani EZE Z

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AlprostadilMajor topic
Anti-Ulcer AgentsMajor topic
Stomach UlcerMajor topic
Adult
Aged
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Female
Gastroscopy
Humans
Male
Middle Aged
Misoprostol
Placebos
Pyloric Antrum
Random Allocation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1334,336Cimetidine in patients with gastric ulcer: a multicentre controlled trial.Br Med J1977https://conductscience.org/library/papers/334336PubMed
2620,911Cimetidine in the treatment of gastric ulcer: review and commentary.Gastroenterology1978https://conductscience.org/library/papers/620911PubMed
3321,925Problems of interpretation in secondary prevention trials in coronary heart disease.Med J Aust1977https://conductscience.org/library/papers/321925PubMed
4747,466Effect of SC-29333, an inhibitor of gastric secretion, on canine gastric mucosal blood flow and serum gastrin levels.Arch Int Pharmacodyn Ther1978https://conductscience.org/library/papers/747466PubMed
5797,257SC-29333: a potent inhibitor of canin gastric secretion.Am J Dig Dis1976https://conductscience.org/library/papers/797257PubMed
6340,332Cimetidine, antacid, and hospitalization in the treatment of benign gastric ulcer: a multicenter double blind study.Gastroenterology1978https://conductscience.org/library/papers/340332PubMed
77,027,858Peptic ulcer: new therapies, new diseases.Ann Intern Med1981https://conductscience.org/library/papers/7027858PubMed
8849,813Gastric and duodenal ulcer healing under placebo treatment.Gastroenterology1977https://conductscience.org/library/papers/849813PubMed
9174,967Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration.Gastroenterology1976https://conductscience.org/library/papers/174967PubMed
106,604,619Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion.Dig Dis Sci1983https://conductscience.org/library/papers/6604619PubMed

1 to 10 of 18

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 64 citations.

PMIDTitleJournalYearIn PapersSource
31,545,918NSAID-induced injury of gastric epithelial cells is reversible: roles of mitochondria, AMP kinase, NGF, and PGE2.Am J Physiol Gastrointest Liver Physiol2019https://conductscience.org/library/papers/31545918PubMed
25,059,824Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.Am J Physiol Gastrointest Liver Physiol2014https://conductscience.org/library/papers/25059824PubMed
7,766,337A comparative overview of the adverse effects of antiulcer drugs.Drug Saf1995https://conductscience.org/library/papers/7766337PubMed
3,932,053Overview of clinical safety with misoprostol.Dig Dis Sci1985https://conductscience.org/library/papers/3932053PubMed
3,792,228Prostaglandins in peptic ulcer disease. An overview of current status and future directions.Drugs1986https://conductscience.org/library/papers/3792228PubMed
3,125,025Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring.Dig Dis Sci1988https://conductscience.org/library/papers/3125025PubMed
3,102,205Misoprostol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.Drugs1987https://conductscience.org/library/papers/3102205PubMed
3,080,288Overview of misoprostol clinical experience.Dig Dis Sci1986https://conductscience.org/library/papers/3080288PubMed
3,080,283Effects of misoprostol on gastric acid and mucus secretion in man.Dig Dis Sci1986https://conductscience.org/library/papers/3080283PubMed
2,081,487Nonsteroidal anti-inflammatory drug therapy and gastric side effects. Does nabumetone provide a solution?Drugs1990https://conductscience.org/library/papers/2081487PubMed

1 to 10 of 12

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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