Paper3965574

Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.

Thiele DL and 1 other. J Immunol, 1985. Cited by 165 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells. Papers, record 3965574. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3965574

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.; PubMed
Journal: J Immunol; PubMed
Year: 1985; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3965574/; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 165; iCite
Relative citation ratio, by iCite: 3.54; iCite
Revised in PubMed: 2013-11-21; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Thiele DL	D L
2	Lipsky PE	P E

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cytotoxicity, Immunologic	Major topic
Immunosuppressive Agents	Major topic
Killer Cells, Natural	Major topic
Leucine	Major topic
Monocytes	Major topic
Adult
Cell Survival
Cells, Cultured
Drug Resistance
Humans
Lysosomes
Macrophages
Time Factors

Source PubMed

Show 7 more topicsShow fewer topics

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AM01251	NIADDK NIH HHS	United States	K08AM001251	PubMed and NIH	NIH RePORTER
AM09989	NIADDK NIH HHS	United States		PubMed	PubMed
AM19329	NIADDK NIH HHS	United States	P01AM019329	PubMed and NIH	NIH RePORTER

Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 165 citations.

PMID	Title	Journal	Year	In Papers	Source
42,098,080	Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy.	Oncogenesis	2026	https://conductscience.org/library/papers/42098080	PubMed
26,246,395	Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.	Inflammopharmacology	2015	https://conductscience.org/library/papers/26246395	PubMed
18,376,070	Apoptosis induced by (di-isopropyloxyphoryl-Trp)2-Lys-OCH3 in K562 and HeLa cells.	J Biosci	2008	https://conductscience.org/library/papers/18376070	PubMed
9,410,920	Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.	J Clin Invest	1997	https://conductscience.org/library/papers/9410920	PubMed
8,428,389	Macrophage depletion decreases IgG anti-DNA in cultures from (NZB x NZW)F1 spleen cells by eliminating the main source of IL-6.	Clin Exp Immunol	1993	https://conductscience.org/library/papers/8428389	PubMed
8,288,726	Analysis of high and low responses to Staphylococcus aureus and interleukin 2 in human B lymphocytes.	J Clin Immunol	1993	https://conductscience.org/library/papers/8288726	PubMed
7,814,647	Diminished expression of CD40 ligand by activated neonatal T cells.	J Clin Invest	1995	https://conductscience.org/library/papers/7814647	PubMed
7,729,923	Impact of antigen-presenting cells on cytokine profiles of human Th clones established after stimulation with Mycobacterium tuberculosis antigens.	Infect Immun	1995	https://conductscience.org/library/papers/7729923	PubMed
7,554,397	Demonstration of virus-specific CD8+ memory T cells in measles-seropositive individuals by in vitro peptide stimulation.	Clin Exp Immunol	1995	https://conductscience.org/library/papers/7554397	PubMed
3,950,542	Destruction of Leishmania mexicana amazonensis amastigotes within macrophages by lysosomotropic amino acid esters.	J Exp Med	1986	https://conductscience.org/library/papers/3950542	PubMed
3,857,595	Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes.	Proc Natl Acad Sci U S A	1985	https://conductscience.org/library/papers/3857595	PubMed
3,594,487	Lysosome rich cells contain the lytic activity of lymphokine-activated killer cell populations.	Cancer Immunol Immunother	1987	https://conductscience.org/library/papers/3594487	PubMed
3,264,807	Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6.	Immunology	1988	https://conductscience.org/library/papers/3264807	PubMed
3,134,296	Mechanisms underlying T-lymphocyte activation: mitogen initiates and IL-2 amplifies the expression of transferrin receptors via intracellular iron level.	Immunology	1988	https://conductscience.org/library/papers/3134296	PubMed
3,131,770	Human monoclonal antibodies produced by primary in vitro immunization of peripheral blood lymphocytes.	Proc Natl Acad Sci U S A	1988	https://conductscience.org/library/papers/3131770	PubMed
2,945,893	Direct T helper-B cell interactions induce an early B cell activation antigen.	J Exp Med	1986	https://conductscience.org/library/papers/2945893	PubMed
2,541,070	The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes.	Immunology	1989	https://conductscience.org/library/papers/2541070	PubMed
2,531,761	Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.	J Clin Invest	1989	https://conductscience.org/library/papers/2531761	PubMed
2,333,285	Interleukin 6 dependence of spontaneous in vitro differentiation of B cells from patients with IgM gammapathy.	Proc Natl Acad Sci U S A	1990	https://conductscience.org/library/papers/2333285	PubMed
2,306,752	Interleukin-2-dependent long-term cultures of low-density lymphocytes allow the proliferation of lymphokine-activated killer cells with natural killer, Ti gamma/delta or TNK phenotype.	Cancer Immunol Immunother	1990	https://conductscience.org/library/papers/2306752	PubMed

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Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Trials
Comments and corrections
References
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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