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Paper2531761

Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.

Thiele DL and 4 others. J Clin Invest, 1989. Cited by 32 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes. Papers, record 2531761. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2531761

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.
PubMed
Journal
J Clin Invest
PubMed
Year
1989
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
32
iCite
Relative citation ratio, by iCite
0.97
iCite
Revised in PubMed
2018-11-13
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Thiele DLD L
2Eigenbrodt MLM L
3Bryde SES E
4Eigenbrodt EHE H
5Lipsky PEP E

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Bone Marrow TransplantationMajor topic
Graft vs Host DiseaseMajor topic
Intestinal DiseasesMajor topic
T-LymphocytesMajor topic
T-Lymphocytes, CytotoxicMajor topic
T-Lymphocytes, Helper-InducerMajor topic
Animals
Antibodies
Antigens, Differentiation, T-Lymphocyte
Antigens, Ly
Colon
Dipeptides
Female
Immunosuppressive Agents
Isoantibodies
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Spleen

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI-24639NIAID NIH HHSUnited StatesR01AI024639PubMed and NIHNIH RePORTER
CA-09082NCI NIH HHSUnited StatesPubMedPubMed
R21AI024639NIHNIH RePORTER

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
137,739Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers.Am J Pathol1979https://conductscience.org/library/papers/37739PubMed
287,465Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus.J Immunol1979https://conductscience.org/library/papers/87465PubMed
36,159,417IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.J Immunol1980https://conductscience.org/library/papers/6159417PubMed
47,015,617Bone marrow transplantation across major histocompatibility barriers in mice. Effect of elimination of T cells from donor grafts by treatment with monoclonal Thy-1.2 plus complement or antibody alone.Transplantation1981https://conductscience.org/library/papers/7015617PubMed
56,221,991Lethal GVHD across minor histocompatibility barriers: nature of the effector cells and role of the H-2 complex.Immunol Rev1983https://conductscience.org/library/papers/6221991PubMed
66,224,882Allosuppressor- and allohelper-T cells in acute and chronic graft-vs.-host (GVH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndromes.J Exp Med1983https://conductscience.org/library/papers/6224882PubMed
76,195,085
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.
Immunol Rev1983https://conductscience.org/library/papers/6195085PubMed
86,229,596Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. V. F1 mice with secondary chronic GVHD contain F1-reactive allohelper but no allosuppressor T cells.J Exp Med1984https://conductscience.org/library/papers/6229596PubMed
96,202,792Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A.J Immunol1984https://conductscience.org/library/papers/6202792PubMed
103,965,574Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.J Immunol1985https://conductscience.org/library/papers/3965574PubMed
113,857,595
Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes.
Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3857595PubMed
123,874,902Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens.J Immunol1985https://conductscience.org/library/papers/3874902PubMed
132,410,497
GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.
J Immunol1985https://conductscience.org/library/papers/2410497PubMed
143,160,804Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.J Exp Med1985https://conductscience.org/library/papers/3160804PubMed
153,896,348Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts.Blood1985https://conductscience.org/library/papers/3896348PubMed
163,876,371Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences.J Immunol1985https://conductscience.org/library/papers/3876371PubMed
172,933,483Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.J Exp Med1985https://conductscience.org/library/papers/2933483PubMed
182,934,477The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes.J Immunol1986https://conductscience.org/library/papers/2934477PubMed
193,484,848Hypersensitivity reactions in the small intestine. VII. Induction of the intestinal phase of murine graft-versus-host-reaction by Lyt 2- T cells activated by I-A alloantigens.Transplantation1986https://conductscience.org/library/papers/3484848PubMed
203,512,763Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.J Exp Med1986https://conductscience.org/library/papers/3512763PubMed

See all 33 references

Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 32 citations.

PMIDTitleJournalYearIn PapersSource
40,563,231
Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8 + Cells and TNF-α Levels in Target Organs, and Protects Mice From Graft-Versus-Host Disease-Related Mortality Through PPAR Activation Without Compromising the Graft-Versus-Tumour Response.
Immunology2025https://conductscience.org/library/papers/40563231PubMed
37,742,740Murine models of graft versus host disease (GVHD): Focus on ocular GVHD.Ocul Surf2023https://conductscience.org/library/papers/37742740PubMed
30,010,833Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation.ILAR J2018https://conductscience.org/library/papers/30010833PubMed
17,242,061An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection.Infect Immun2007https://conductscience.org/library/papers/17242061PubMed
12,117,872Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine.Gut2002https://conductscience.org/library/papers/12117872PubMed
11,100,271Genetic factors influencing the development of chronic graft-versus-host disease in a murine model.Bone Marrow Transplant2000https://conductscience.org/library/papers/11100271PubMed
11,051,280T-cell activation and differentiation are regulated by TNF during murine DBA/2-->B6D2F1 intestinal graft-versus-host disease.J Clin Immunol2000https://conductscience.org/library/papers/11051280PubMed
8,398,810Effect of chronic graft-versus-host disease on the intestine in adult BDF1 mice.Int J Exp Pathol1993https://conductscience.org/library/papers/8398810PubMed
7,704,325Cellular blebbing in superficial colonic epithelial cells occurring with murine graft-versus-host disease.Virchows Arch1995https://conductscience.org/library/papers/7704325PubMed
2,240,158Histologic similarity of murine colonic graft-versus-host disease (GVHD) to human colonic GVHD and inflammatory bowel disease.Am J Pathol1990https://conductscience.org/library/papers/2240158PubMed
1,605,898Thalidomide in human immunodeficiency virus (HIV) patients. A review of safety considerations.Drug Saf1992https://conductscience.org/library/papers/1605898PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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