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Paper · 40213562

Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer.

Yan J and 3 others. Front Immunol, 2025. Cited by 3 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer. Papers, record 40213562. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40213562

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer.
PubMed
Journal
Front Immunol
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
3
iCite
Revised in PubMed
2025-04-12
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yan JJianing
2Wang JJingzhi
3Miao MMin
4Shao YYongfu

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Colorectal NeoplasmsMajor topic
Biomarkers, TumorMajor topic
ApoptosisMajor topic
Tumor Suppressor Protein p53Major topic
Nuclear ProteinsMajor topic
Humans
Gene Expression Regulation, Neoplastic
Tumor Microenvironment
Drug Resistance, Neoplasm
Prognosis
Cell Line, Tumor

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
138,406,595Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review).Oncol Lett2024https://conductscience.org/library/papers/38406595PubMed
239,267,056Multi‑omics identification of a signature based on malignant cell-associated ligand-receptor genes for lung adenocarcinoma.BMC Cancer2024https://conductscience.org/library/papers/39267056PubMed
336,816,981Advances in immune checkpoint inhibitor combination strategies for microsatellite stable colorectal cancer.Front Oncol2023https://conductscience.org/library/papers/36816981PubMed
430,566,255Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus.Exp Dermatol2019https://conductscience.org/library/papers/30566255PubMed
530,389,923Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.Nat Commun2018https://conductscience.org/library/papers/30389923PubMed
638,315,776The Web-Based Portal SpatialTME Integrates Histological Images with Single-Cell and Spatial Transcriptomics to Explore the Tumor Microenvironment.Cancer Res2024https://conductscience.org/library/papers/38315776PubMed
726,656,090Correlating chemical sensitivity and basal gene expression reveals mechanism of action.Nat Chem Biol2016https://conductscience.org/library/papers/26656090PubMed
833,726,687A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.BMC Cancer2021https://conductscience.org/library/papers/33726687PubMed
930,668,768Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.Neuro Oncol2019https://conductscience.org/library/papers/30668768PubMed
1033,179,754TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment.Nucleic Acids Res2021https://conductscience.org/library/papers/33179754PubMed

1 to 10 of 33

See all 33 references

Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3 citations.

PMIDTitleJournalYearIn PapersSource
42,724,844Microplastics and nanoplastics-related genes signature predicts prognosis in pancreatic ductal adenocarcinoma and functional validation of interleukin 1 alpha.Transl Cancer Res2026https://conductscience.org/library/papers/42724844PubMed
42,572,974Comprehensive Pan-Cancer Analysis of ABCA1: Insights From Multi-Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma.Cell Biochem Funct2026https://conductscience.org/library/papers/42572974PubMed
42,535,370Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review).Int J Mol Med2026https://conductscience.org/library/papers/42535370PubMed
42,421,031Regulated cell death plasticity in cancer: thresholds, reversibility, and therapeutic failure.J Transl Med2026https://conductscience.org/library/papers/42421031PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
SLFN1191,607PubTator's text mininghttps://conductscience.org/library/genes/91607NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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