Paper · 40315972

Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening.

Ito S and 10 others. Clin Gastroenterol Hepatol, 2025. Cited by 2 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening. Papers, record 40315972. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40315972

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening.; PubMed
Journal: Clin Gastroenterol Hepatol; PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/40315972/; PubMed
DOI: https://doi.org/10.1016/j.cgh.2025.03.006; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12354148/; PubMed
The journal: https://conductscience.org/library/journal-index/101160775; PubMed
Citations, by iCite: 2; iCite
Revised in PubMed: 2025-10-29; PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Ito S	Satoko
2	Xicola RM	Rosa M
3	Sra M	Manraj
4	Potnis KC	Kunal C
5	Singh V	Vinit
6	Gershkovich P	Peter
7	Stites E	Edward
8	Gibson J	Joanna
9	Krumholz HM	Harlan M
10	Llor X	Xavier

1 to 10 of 11Source PubMed

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Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cost-Benefit Analysis	Major topic
Colorectal Neoplasms, Hereditary Nonpolyposis	Major topic
Early Detection of Cancer	Major topic
Colorectal Neoplasms	Major topic
Genetic Testing	Major topic
Mass Screening	Major topic
Humans
Male
Middle Aged
Female
Adult
Aged
United States
Prospective Studies

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
K01 HL175220	NHLBI NIH HHS	United States	K01HL175220	PubMed and NIH	NIH RePORTER
P30 CA016359	NCI NIH HHS	United States	P30CA016359	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	31,816,299	Low Rates of Genetic Counseling and Testing in Individuals at Risk for Lynch Syndrome Reported in the National Health Interview Survey.	Gastroenterology	2020	https://conductscience.org/library/papers/31816299	PubMed
2	18,938,166	Bleeding and perforation after outpatient colonoscopy and their risk factors in usual clinical practice.	Gastroenterology	2008	https://conductscience.org/library/papers/18938166	PubMed
3	31,337,882	Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.	Genet Med	2020	https://conductscience.org/library/papers/31337882	PubMed
4	19,143,775	Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation.	Colorectal Dis	2009	https://conductscience.org/library/papers/19143775	PubMed
5	34,556,502	Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing.	J Med Genet	2022	https://conductscience.org/library/papers/34556502	PubMed
6	32,500,284	Underutilization of Lynch Syndrome Screening at Two Large Veterans Affairs Medical Centers.	Dig Dis Sci	2020	https://conductscience.org/library/papers/32500284	PubMed
7	34,945,755	Economic Evaluation of Universal Lynch Syndrome Screening Protocols among Newly Diagnosed Patients with Colorectal Cancer.	J Pers Med	2021	https://conductscience.org/library/papers/34945755	PubMed
8	16,421,367	Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome.	N Engl J Med	2006	https://conductscience.org/library/papers/16421367	PubMed
9	27,261,338	Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.	Gut	2017	https://conductscience.org/library/papers/27261338	PubMed
10	29,121,143	Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults.	JAMA Oncol	2018	https://conductscience.org/library/papers/29121143	PubMed

1 to 10 of 36

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Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2 citations.

PMID	Title	Journal	Year	In Papers	Source
42,944,990	Diagnostic yield and clinical utilitY of strategies for identifying Lynch syndrome in those with colorectal neoplasia.	Fam Cancer	2026	https://conductscience.org/library/papers/42944990	PubMed
42,589,309	Genetic Landscape of Lynch Syndrome in a High-Risk Serbian Cohort: Predominance of MLH1 Variants and Implications for Risk-Based Testing.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42589309	PubMed
42,041,703	Suboptimal Adherence to Hereditary Cancer Risk Management Guidelines: A Cohort Study of High-Risk Individuals in Newfoundland and Labrador, Canada.	Curr Oncol	2026	https://conductscience.org/library/papers/42041703	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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