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Paper · 40537745

The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25.

Tenhaken V and 3 others. BMC Cancer, 2025. Cited by 3 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25. Papers, record 40537745. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40537745

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25.
PubMed
Journal
BMC Cancer
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
3
iCite
Revised in PubMed
2026-01-27
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tenhaken VVictoria
2Seternes OMOle-Morten
3Cascorbi IIngolf
4Bruckmueller HHenrike

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
MicroRNAsMajor topic
Dual Specificity Phosphatase 2Major topic
NeoplasmsMajor topic
Humans
Gene Expression Regulation, Neoplastic
MAP Kinase Signaling System
Cell Line, Tumor
RNA, Long Noncoding

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References121

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
127,647,143Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in berb erine-induced multiple myeloma cells.Funct Integr Genomics2017https://conductscience.org/library/papers/27647143PubMed
225,973,317The microRNA-520a-3p inhibits proliferation, apoptosis and metastasis by targeting MAP3K2 in non-small cell lung cancer.Am J Cancer Res2015https://conductscience.org/library/papers/25973317PubMed
329,541,187Differential expression of DUSP2 in left- and right-sided colon cancer is associated with poor prognosis in colorectal cancer.Oncol Lett2018https://conductscience.org/library/papers/29541187PubMed
426,833,217The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms.BMC Cancer2016https://conductscience.org/library/papers/26833217PubMed
537,739,277DUSP2 affects bladder cancer prognosis by down-regulating MEK/ERK and P38 MAPK signaling pathways through PTPN7.Cell Signal2023https://conductscience.org/library/papers/37739277PubMed
636,140,219The Role of miR-29s in Human Cancers-An Update.Biomedicines2022https://conductscience.org/library/papers/36140219PubMed
729,509,059MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4.Cancer Biol Ther2018https://conductscience.org/library/papers/29509059PubMed
829,898,407Integrated Molecular Characterization of Testicular Germ Cell Tumors.Cell Rep2018https://conductscience.org/library/papers/29898407PubMed
924,212,931The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.Cell Death Differ2013https://conductscience.org/library/papers/24212931PubMed
1033,114,775Prognostic Stratification of Bladder Cancer Patients with a MicroRNA-based Approach.Cancers (Basel)2020https://conductscience.org/library/papers/33114775PubMed

1 to 10 of 121

See all 121 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3 citations.

PMIDTitleJournalYearIn PapersSource
42,866,857DUSP13 promotes prostate cancer progression by regulating the ERK1/2 pathway.Transl Androl Urol2026https://conductscience.org/library/papers/42866857PubMed
42,353,343Comparative Analysis of Serum and Tissue miRNA Expression Profiles and Regulatory Pathways in Early-Stage Ovarian Cancer Using Public Databases.Int J Mol Sci2026https://conductscience.org/library/papers/42353343PubMed
40,981,381Navigating the Landscape of Exosomal microRNAs: Charting Their Pivotal Role as Biomarkers in Hematological Malignancies.Noncoding RNA2025https://conductscience.org/library/papers/40981381PubMed

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DUSP21,844PubTator's text mininghttps://conductscience.org/library/genes/1844NCBI Gene
MIR1225100,188,847PubTator's text mininghttps://conductscience.org/library/genes/100188847NCBI Gene
MIR17406,952PubTator's text mininghttps://conductscience.org/library/genes/406952NCBI Gene
MIR17HG407,975PubTator's text mininghttps://conductscience.org/library/genes/407975NCBI Gene
MIR20A406,982PubTator's text mininghttps://conductscience.org/library/genes/406982NCBI Gene
MIR29B1407,024PubTator's text mininghttps://conductscience.org/library/genes/407024NCBI Gene
MIR520A574,467PubTator's text mininghttps://conductscience.org/library/genes/574467NCBI Gene
MIR520C574,476PubTator's text mininghttps://conductscience.org/library/genes/574476NCBI Gene
MIR9-3407,051PubTator's text mininghttps://conductscience.org/library/genes/407051NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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