Paper · 41345709

Stratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles.

Oosterlynck M and 13 others. Transl Neurodegener, 2025. Cited by 3 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Stratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles. Papers, record 41345709. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41345709

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Stratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles.; PubMed
Journal: Transl Neurodegener; PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41345709/; PubMed
DOI: https://doi.org/10.1186/s40035-025-00519-z; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12679798/; PubMed
The journal: https://conductscience.org/library/journal-index/101591861; PubMed
Citations, by iCite: 3; iCite
Revised in PubMed: 2025-12-07; PubMed

Authors14

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Oosterlynck M	Marie
2	Leroux E	Elodie
3	Namasivayam B	Balasubramaniam
4	Bouillet T	Thomas
5	Caillierez R	Raphaelle
6	Loyens A	Anne
7	Mazur D	Daniele
8	Perbet R	Romain
9	Lefebvre C	Christophe
10	Aboulouard S	Soulaimane

1 to 10 of 14Source PubMed

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Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Alzheimer Disease	Major topic
Extracellular Vesicles	Major topic
Brain	Major topic
Humans
Proteomics
Animals
Male
Female
tau Proteins
Mice
Aged
Aged, 80 and over
Mice, Transgenic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References75

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	35,379,992	New insights into the genetic etiology of Alzheimer's disease and related dementias.	Nat Genet	2022	https://conductscience.org/library/papers/35379992	PubMed
2	31,038,156	Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.	Brain	2019	https://conductscience.org/library/papers/31038156	PubMed
3	27,943,212	A Method for Isolation of Extracellular Vesicles and Characterization of Exosomes from Brain Extracellular Space.	Methods Mol Biol	2017	https://conductscience.org/library/papers/27943212	PubMed
4	19,029,910	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Nat Biotechnol	2008	https://conductscience.org/library/papers/19029910	PubMed
5	23,898,162	Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.	Proc Natl Acad Sci U S A	2013	https://conductscience.org/library/papers/23898162	PubMed
6	37,204,850	Alzheimer's disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice.	Alzheimers Dement	2023	https://conductscience.org/library/papers/37204850	PubMed
7	26,154,623	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals.	J Extracell Vesicles	2015	https://conductscience.org/library/papers/26154623	PubMed
8	39,572,740	Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.	Nat Neurosci	2025	https://conductscience.org/library/papers/39572740	PubMed
9	18,725,412	Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.	J Biol Chem	2008	https://conductscience.org/library/papers/18725412	PubMed
10	27,567,840	Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice.	J Alzheimers Dis	2016	https://conductscience.org/library/papers/27567840	PubMed

1 to 10 of 75

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Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3 citations.

PMID	Title	Journal	Year	In Papers	Source
42,938,995	Extracellular Vesicle Communication in the Central Nervous System: Mechanisms, Disease States, and Therapeutic Opportunities.	Bioengineering (Basel)	2026	https://conductscience.org/library/papers/42938995	PubMed
42,816,862	Microglia-derived extracellular vesicle content as a biomarker for early detection of Alzheimer's disease.	Transl Neurodegener	2026	https://conductscience.org/library/papers/42816862	PubMed
42,661,225	HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease.	Transl Neurodegener	2026	https://conductscience.org/library/papers/42661225	PubMed
42,601,641	Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.	Acta Neuropathol Commun	2026	https://conductscience.org/library/papers/42601641	PubMed
42,298,542	Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease.	J Biomed Sci	2026	https://conductscience.org/library/papers/42298542	PubMed
42,212,061	Brain-Derived Extracellular Vesicle Subpopulations: from Bulk Measurements to Single-Entity Assays.	JACS Au	2026	https://conductscience.org/library/papers/42212061	PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
MAPT	4,137	PubTator's text mining	https://conductscience.org/library/genes/4137

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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