Paper · 415110

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

Tada T and 4 others. J Exp Med, 1978. Cited by 361 papers, by iCite.

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ConductScience Library. Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells. Papers, record 415110. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/415110

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.; PubMed
Journal: J Exp Med; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/415110/; PubMed
DOI: https://doi.org/10.1084/jem.147.2.446; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2184496/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 361; iCite
Relative citation ratio, by iCite: 7.37; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Tada T	T
2	Takemori T	T
3	Okumura K	K
4	Nonaka M	M
5	Tokuhisa T	T

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Genes, MHC Class II	Major topic
Immunologic Memory	Major topic
Isoantigens	Major topic
Lymphocyte Cooperation	Major topic
T-Lymphocytes	Major topic
Animals
Antibody Formation
B-Lymphocytes
Carrier Proteins
Cell Adhesion
Cell Separation
Haptens
Mice
Spleen

Source PubMed

Grants0

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Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	14,076,917	IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS.	Proc Soc Exp Biol Med	1963	https://conductscience.org/library/papers/14076917	PubMed
2	73,181	Evidence for an immunoglobulin-dependent antigen-specific helper T cell.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/73181	PubMed
3	302,180	The significance of T-B collaboration across haplotype barriers.	Cold Spring Harb Symp Quant Biol	1977	https://conductscience.org/library/papers/302180	PubMed
4	301,171	Cell surface immunoglobulin. XX. Antibody responsiveness of subpopulations of B lymphocytes bearing different isotypes.	J Exp Med	1977	https://conductscience.org/library/papers/301171	PubMed
5	4,503,682	Replacement of T-cell function by a T-cell product.	Nat New Biol	1972	https://conductscience.org/library/papers/4503682	PubMed
6	4,125,546	Hapten-specific IgE antibody responses in mice. II. Cooperative interactions between adoptively transferred T and B lymphocytes in the development of IgE response.	J Exp Med	1973	https://conductscience.org/library/papers/4125546	PubMed
7	4,126,290	Reconstitution of T cell-depleted spleen cell populations by factors derived from T cells. 3. Mechanism of action of T cell-derived factors.	J Immunol	1973	https://conductscience.org/library/papers/4126290	PubMed
8	4,126,287	Regulation of antibody response in vitro. VI. Carrier-specific helper cells for IgG and IgE antibody response.	J Immunol	1973	https://conductscience.org/library/papers/4126287	PubMed
9	4,126,264	Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.	Proc Natl Acad Sci U S A	1973	https://conductscience.org/library/papers/4126264	PubMed
10	4,122,709	Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.	J Exp Med	1973	https://conductscience.org/library/papers/4122709	PubMed

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Cited by106

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 361 citations.

PMID	Title	Journal	Year	In Papers	Source
40,859,352	Characterization of the tumor immune microenvironment in pregnancy-associated breast cancer through multiplex immunohistochemistry and transcriptome analyses.	Breast Cancer Res	2025	https://conductscience.org/library/papers/40859352	PubMed
38,053,545	A glance through the effects of CD4+ T cells, CD8+ T cells, and cytokines on Alzheimer's disease.	Comput Struct Biotechnol J	2023	https://conductscience.org/library/papers/38053545	PubMed
37,197,701	Association between HSP-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma.	Ophthalmol Sci	2023	https://conductscience.org/library/papers/37197701	PubMed
36,135,184	Optic Neuritis in Multiple Sclerosis-A Review of Molecular Mechanisms Involved in the Degenerative Process.	Curr Issues Mol Biol	2022	https://conductscience.org/library/papers/36135184	PubMed
35,902,536	Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis.	Neurotherapeutics	2022	https://conductscience.org/library/papers/35902536	PubMed
33,050,549	Role of CD4+ T Cells in Allergic Airway Diseases: Learning from Murine Models.	Int J Mol Sci	2020	https://conductscience.org/library/papers/33050549	PubMed
31,822,860	Animal models of scarring control.	Eye (Lond)	2020	https://conductscience.org/library/papers/31822860	PubMed
29,675,022	Immunoporosis: Immunology of Osteoporosis-Role of T Cells.	Front Immunol	2018	https://conductscience.org/library/papers/29675022	PubMed
29,563,615	When worlds collide: Th17 and Treg cells in cancer and autoimmunity.	Cell Mol Immunol	2018	https://conductscience.org/library/papers/29563615	PubMed
29,503,203	Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.	Mol Ther	2018	https://conductscience.org/library/papers/29503203	PubMed

1 to 10 of 106

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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