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Paper · 73181

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

Janeway CA and 4 others. Proc Natl Acad Sci U S A, 1977. Cited by 193 papers, by iCite.

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ConductScience Library. Evidence for an immunoglobulin-dependent antigen-specific helper T cell. Papers, record 73181. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/73181

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Evidence for an immunoglobulin-dependent antigen-specific helper T cell.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
193
iCite
Relative citation ratio, by iCite
3.84
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Janeway CA JrC A
2Murgita RAR A
3Weinbaum FIF I
4Asofsky RR
5Wigzell HH

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ImmunoglobulinsMajor topic
T-LymphocytesMajor topic
Animals
Antibodies
Antibodies, Anti-Idiotypic
Epitopes
Fluorescent Antibody Technique
Immunoglobulin mu-Chains
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,078,834Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.J Immunol1975https://conductscience.org/library/papers/1078834PubMed
21,078,835Cellular cooperation during in vivo anti-hapten antibody responses. II. The effect of in vivo and in vitro x-irradiation on T and B cells.J Immunol1975https://conductscience.org/library/papers/1078835PubMed
31,078,836
Cellular cooperation during in vivo anti-hapten antibody responses. III. The helper cell activity of activated thymocytes, of spleen cells treated with anti-theta serum, and of spleen cells from anti-thymocyte serum-treated or adult thymectomized donors.
J Immunol1975https://conductscience.org/library/papers/1078836PubMed
41,085,324T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.J Exp Med1976https://conductscience.org/library/papers/1085324PubMed
51,085,337Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1085337PubMed
61,090,698Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.J Exp Med1975https://conductscience.org/library/papers/1090698PubMed
7136,472Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.J Immunol1976https://conductscience.org/library/papers/136472PubMed
814,978,857The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.Eur J Immunol1971https://conductscience.org/library/papers/14978857PubMed
9300,494A simple conservative explanation of the H-2 restriction of interactions between lymphocytes.Scand J Immunol1977https://conductscience.org/library/papers/300494PubMed
10320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed

1 to 10 of 21

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Cited by42

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 193 citations.

PMIDTitleJournalYearIn PapersSource
9,557,653Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system.J Virol1998https://conductscience.org/library/papers/9557653PubMed
8,550,067T-cell dependent response to immune complexes abrogates B-cell unresponsiveness to pneumococcal cell wall polysaccharide.Immunology1995https://conductscience.org/library/papers/8550067PubMed
7,299,344Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. III. Detection of Id-460 in normal serum that does not bind dinitrophenyl.J Exp Med1981https://conductscience.org/library/papers/7299344PubMed
7,035,601T cell replacing factor substitutes for an I-J+ idiotype-specific T helper cell.J Exp Med1982https://conductscience.org/library/papers/7035601PubMed
7,028,912Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. II. Transient idiotypic dominance.J Exp Med1981https://conductscience.org/library/papers/7028912PubMed
6,980,253Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.J Exp Med1982https://conductscience.org/library/papers/6980253PubMed
6,977,611T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.J Exp Med1982https://conductscience.org/library/papers/6977611PubMed
6,977,609Two Ly-2 T helper cell subsets distinguished by Qa-1 phenotype. The priming environment determines whether one or both subsets will be generated.J Exp Med1982https://conductscience.org/library/papers/6977609PubMed
6,973,605T lymphocytes specific for immunoglobulin allotype. I. Igh-1b-specific T cells demonstrated by suppression in vivo and cytotoxicity in vitro.J Exp Med1981https://conductscience.org/library/papers/6973605PubMed
6,973,603Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted.J Exp Med1981https://conductscience.org/library/papers/6973603PubMed

1 to 10 of 42

See all 42 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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