Paper · 41533211
TREM2-mediated Crosstalk in ALS: Microglial Fate Transition, Protein Aggregate Clearance, and Peripheral Nerve Repair.
Shu X and 2 others. Neurosci Bull, 2026. Cited by 1 paper, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. TREM2-mediated Crosstalk in ALS: Microglial Fate Transition, Protein Aggregate Clearance, and Peripheral Nerve Repair. Papers, record 41533211. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41533211
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Paper
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- Title
- TREM2-mediated Crosstalk in ALS: Microglial Fate Transition, Protein Aggregate Clearance, and Peripheral Nerve Repair.
- PubMed
Topics0
NLM's MeSH indexing of the paper, its major topics first.
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Grants0
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None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
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None in this release.
References26
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 29,605,155 | ALS Genes in the Genomic Era and their Implications for FTD. | Trends Genet | 2018 | https://conductscience.org/library/papers/29605155 | PubMed |
| 2 | 37,688,660 | PIKFYVE Inhibition, A Neuronal "Emetic" for Treating ALS? | Neurosci Bull | 2023 | https://conductscience.org/library/papers/37688660 | PubMed |
| 3 | 23,318,515 | Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. | JAMA Neurol | 2013 | https://conductscience.org/library/papers/23318515 | PubMed |
| 4 | 24,535,663 | TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. | JAMA Neurol | 2014 | https://conductscience.org/library/papers/24535663 | PubMed |
| 5 | 8,446,170 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. | Nature | 1993 | https://conductscience.org/library/papers/8446170 | PubMed |
| 6 | 8,209,258 | Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. | Science | 1994 | https://conductscience.org/library/papers/8209258 | PubMed |
| 7 | 8,673,102 | Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. | Nat Genet | 1996 | https://conductscience.org/library/papers/8673102 | PubMed |
| 8 | 28,602,351 | A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. | Cell | 2017 | https://conductscience.org/library/papers/28602351 | PubMed |
| 9 | 28,930,663 | The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. | Immunity | 2017 | https://conductscience.org/library/papers/28930663 | PubMed |
| 10 | 30,140,051 | Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. | Nat Rev Immunol | 2018 | https://conductscience.org/library/papers/30140051 | PubMed |
1 to 10 of 26
See all 26 referencesCited by1
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.
| PMID | Title | Journal | Year | In Papers |
|---|---|---|---|---|
| 42,359,357 | Innate immune crosstalk in ALS/FTD pathogenesis. | Cell Insight | 2026 | https://conductscience.org/library/papers/42359357 |
Source PubMed
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| TREM2 | 54,209 | PubTator's text mining | https://conductscience.org/library/genes/54209 |
Source NCBI Gene
Drugs0
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None in this release.
Data0
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None in this release.
Data dates
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- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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