Paper · 42870544

S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways.

Sakamoto E and 4 others. FASEB J, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways. Papers, record 42870544. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42870544

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways.
Journal: FASEB J
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42870544/
DOI: https://doi.org/10.1096/fj.202603197r
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13662504/
The journal: https://conductscience.org/library/journal-index/8804484
Revised in PubMed: 2026-10-16

Source PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Sakamoto E	Eijiro	https://orcid.org/0009-0007-1742-7253
2	Yoshimoto T	Tetsuya
3	Kido R	Rie
4	Kajiya M	Mikihito	https://orcid.org/0000-0001-6652-0007
5	Yumoto H	Hiromichi

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
RANK Ligand	Major topic
Cytokine Receptor gp130	Major topic
Osteocytes	Major topic
Receptors, Interleukin-6	Major topic
Interleukin-6	Major topic
Calgranulin B	Major topic
Signal Transduction	Major topic
Animals
Mice
Bone Resorption
Mice, Inbred C57BL

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
19K19000	MEXT \| JSPS \| Japan Society for the Promotion of Science (JSPS)			PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References51

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	22,668,415	Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice.	Biotechniques	2012	https://conductscience.org/library/papers/22668415	PubMed
2	30,083,975	Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer.	Inflamm Res	2018	https://conductscience.org/library/papers/30083975	PubMed
3	28,278,513	IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro.	Cell Physiol Biochem	2017	https://conductscience.org/library/papers/28278513	PubMed
4	29,942,307	S100A8/A9 in Inflammation.	Front Immunol	2018	https://conductscience.org/library/papers/29942307	PubMed
5	34,337,974	The osteocyte as a signaling cell.	Physiol Rev	2022	https://conductscience.org/library/papers/34337974	PubMed
6	27,925,202	Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts.	J Cell Physiol	2017	https://conductscience.org/library/papers/27925202	PubMed
7	37,866,240	The interleukin-6 signal regulates orthodontic tooth movement and pain.	Biochem Biophys Res Commun	2023	https://conductscience.org/library/papers/37866240	PubMed
8	31,921,183	TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation.	Front Immunol	2019	https://conductscience.org/library/papers/31921183	PubMed
9	16,573,830	Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products.	Cardiovasc Diabetol	2006	https://conductscience.org/library/papers/16573830	PubMed
10	16,741,736	Interleukin-6 and its receptor: from bench to bedside.	Med Microbiol Immunol	2006	https://conductscience.org/library/papers/16741736	PubMed

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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