Paper · 31921183

TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation.

Marahleh A and 9 others. Front Immunol, 2019. Cited by 222 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation. Papers, record 31921183. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31921183

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation.; PubMed
Journal: Front Immunol; PubMed
Year: 2019; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/31921183/; PubMed
DOI: https://doi.org/10.3389/fimmu.2019.02925; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6923682/; PubMed
The journal: https://conductscience.org/library/journal-index/101560960; PubMed
Citations, by iCite: 222; iCite
Relative citation ratio, by iCite: 11.6; iCite
Revised in PubMed: 2020-11-09; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Marahleh A	Aseel
2	Kitaura H	Hideki
3	Ohori F	Fumitoshi
4	Kishikawa A	Akiko
5	Ogawa S	Saika
6	Shen WR	Wei-Ren
7	Qi J	Jiawei
8	Noguchi T	Takahiro
9	Nara Y	Yasuhiko
10	Mizoguchi I	Itaru

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gene Expression Regulation	Major topic
Osteoclasts	Major topic
Osteocytes	Major topic
RANK Ligand	Major topic
Tumor Necrosis Factor-alpha	Major topic
Animals
Biomarkers
Biopsy
Cells, Cultured
Coculture Techniques
Immunophenotyping
MAP Kinase Signaling System
Mice
Osteogenesis
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	30,104,531	Involvement of Osteocytes in the Action of Pasteurella multocida Toxin.	Toxins (Basel)	2018	https://conductscience.org/library/papers/30104531	PubMed
2	10,637,272	Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.	J Exp Med	2000	https://conductscience.org/library/papers/10637272	PubMed
3	24,647,229	TNF and MAP kinase signalling pathways.	Semin Immunol	2014	https://conductscience.org/library/papers/24647229	PubMed
4	29,240,821	Tumor necrosis factor-α antagonist diminishes osteocytic RANKL and sclerostin expression in diabetes rats with periodontitis.	PLoS One	2017	https://conductscience.org/library/papers/29240821	PubMed
5	16,258,960	Buried alive: how osteoblasts become osteocytes.	Dev Dyn	2006	https://conductscience.org/library/papers/16258960	PubMed
6	15,470,024	Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo.	J Immunol	2004	https://conductscience.org/library/papers/15470024	PubMed
7	16,294,221	M-CSF mediates TNF-induced inflammatory osteolysis.	J Clin Invest	2005	https://conductscience.org/library/papers/16294221	PubMed
8	1,609,628	Isolation and purification of osteocytes.	J Bone Miner Res	1992	https://conductscience.org/library/papers/1609628	PubMed
9	17,308,163	Bone remodeling.	Ann N Y Acad Sci	2006	https://conductscience.org/library/papers/17308163	PubMed
10	25,070,541	Receptor activator of nuclear factor-κB ligand and sclerostin expression in osteocytes of alveolar bone in rats with ligature-induced periodontitis.	J Periodontol	2014	https://conductscience.org/library/papers/25070541	PubMed

1 to 10 of 41

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Cited by181

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 222 citations.

PMID	Title	Journal	Year	In Papers	Source
42,921,032	Gut microbiota-immune-bone axis in osteoporosis: mechanisms and intervention strategies.	Front Pharmacol	2026	https://conductscience.org/library/papers/42921032	PubMed
42,870,544	S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways.	FASEB J	2026	https://conductscience.org/library/papers/42870544	PubMed
42,793,245	LPS-Induced TNF-α and IL-1 Signaling in Periodontitis: Molecular Mechanisms and Therapeutic Opportunities.	Curr Issues Mol Biol	2026	https://conductscience.org/library/papers/42793245	PubMed
42,781,320	Therapeutic Potential of Exosomes in Bone Infection: Mechanisms of Action, Engineering Strategies, and Translational Applications.	Int J Nanomedicine	2026	https://conductscience.org/library/papers/42781320	PubMed
42,756,671	Impaired Bone Physiology in Rheumatoid Arthritis: Can the Wnt Pathway be the Connecting Link Between the Synovium and the Bone?	Mediterr J Rheumatol	2026	https://conductscience.org/library/papers/42756671	PubMed
42,676,880	Immune ageing in skeletal fragility: clonal haematopoiesis and failure of inflammatory resolution during fracture repair.	Front Immunol	2026	https://conductscience.org/library/papers/42676880	PubMed
42,597,306	Circadian regulation of osteoclast lysosomal-resorption machinery: implications for osteoporosis therapy.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/42597306	PubMed
42,591,919	RANKL-convergent osteoimmune network framework in osteoporosis: integrating macrophage activation, T-cell imbalance, and cytokine crosstalk.	Front Immunol	2026	https://conductscience.org/library/papers/42591919	PubMed
42,564,269	TNF-α blockade with adalimumab restores bone metabolism in rheumatoid arthritis by regulating cytokines and inflammatory cell infiltration.	Front Immunol	2026	https://conductscience.org/library/papers/42564269	PubMed
42,528,636	Osteoimmune senescence in aging-related bone diseases.	Front Immunol	2026	https://conductscience.org/library/papers/42528636	PubMed

1 to 10 of 181

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CSF1	1,435	PubTator's text mining	https://conductscience.org/library/genes/1435	NCBI Gene
LTBR	4,055	PubTator's text mining	https://conductscience.org/library/genes/4055	NCBI Gene
TNF	7,124	PubTator's text mining	https://conductscience.org/library/genes/7124	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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