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Paper · 42872025

FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells.

Huang Z and 5 others. iScience, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells. Papers, record 42872025. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42872025

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells.
Journal
iScience
Year
2026
Publication types
Journal Article
Revised in PubMed
2026-10-15

Source PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Huang ZZixin
2Lenhardt SSonja
3Snyder PPetra
4Bulldan AAhmed
5Hausch FFelix
6Loewer AAlexander

Source PubMed

Topics0

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None in this release.

Grants0

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None in this release.

Trials0

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None in this release.

Comments and corrections0

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None in this release.

References57

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,871,312ALK1 signaling in development and disease: new paradigms.Cell Mol Life Sci2017https://conductscience.org/library/papers/28871312PubMed
236,717,825FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.Cell Commun Signal2023https://conductscience.org/library/papers/36717825PubMed
332,858,894It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology.Cells2020https://conductscience.org/library/papers/32858894PubMed
426,471,266DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.Arterioscler Thromb Vasc Biol2015https://conductscience.org/library/papers/26471266PubMed
511,532,220The Smads.Genome Biol2001https://conductscience.org/library/papers/11532220PubMed
69,045,666Processing of the transforming growth factor beta type I and II receptors. Biosynthesis and ligand-induced regulation.J Biol Chem1997https://conductscience.org/library/papers/9045666PubMed
716,765,933Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.Dev Biol2006https://conductscience.org/library/papers/16765933PubMed
828,447,104BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.Cell Mol Life Sci2017https://conductscience.org/library/papers/28447104PubMed
935,044,529The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function.Cell Mol Life Sci2022https://conductscience.org/library/papers/35044529PubMed
1029,540,357Pulmonary arterial hypertension: pathogenesis and clinical management.BMJ2018https://conductscience.org/library/papers/29540357PubMed

Cited by0

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None in this release.

Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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