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Paper · 16765933

Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.

Arnold SJ and 4 others. Dev Biol, 2006. Cited by 131 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Papers, record 16765933. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16765933

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.
PubMed
Journal
Dev Biol
PubMed
Year
2006
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
131
iCite
Relative citation ratio, by iCite
2.44
iCite
Revised in PubMed
2025-05-29
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Arnold SJSebastian J
2Maretto SSilvia
3Islam AAyesha
4Bikoff EKElizabeth K
5Robertson EJElizabeth J

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Embryo, MammalianMajor topic
Signal TransductionMajor topic
Smad1 ProteinMajor topic
Smad5 ProteinMajor topic
Smad8 ProteinMajor topic
Amino Acid Sequence
Animals
Female
Genetic Carrier Screening
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Molecular Sequence Data

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
059312Wellcome TrustUnited KingdomPubMed
214175Wellcome TrustUnited KingdomPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References63

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,466,190Genetic analysis of the mammalian transforming growth factor-beta superfamily.Endocr Rev2002https://conductscience.org/library/papers/12466190PubMed
215,084,259Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.Cell2004https://conductscience.org/library/papers/15084259PubMed
310,226,013The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.Development1999https://conductscience.org/library/papers/10226013PubMed
414,570,583Nodal signaling in vertebrate development.Annu Rev Cell Dev Biol2003https://conductscience.org/library/papers/14570583PubMed
59,529,255Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.Cell1998https://conductscience.org/library/papers/9529255PubMed
611,566,864Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.Development2001https://conductscience.org/library/papers/11566864PubMed
710,079,226Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.Development1999https://conductscience.org/library/papers/10079226PubMed
88,898,212Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development.Development1996https://conductscience.org/library/papers/8898212PubMed
99,702,197Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.Mol Cell1998https://conductscience.org/library/papers/9702197PubMed
108,543,149Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.Genes Dev1995https://conductscience.org/library/papers/8543149PubMed

1 to 10 of 63

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Cited by80

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 131 citations.

PMIDTitleJournalYearIn PapersSource
42,872,025FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells.iScience2026https://conductscience.org/library/papers/42872025PubMed
42,856,601Optogenetic BMP4 models symmetry breaking and primitive streak formation in hPSCs.bioRxiv2026https://conductscience.org/library/papers/42856601PubMed
42,370,939Dampened HPG axis activity and altered ovarian gene transcription in Dummerstorf high-fertility mouse line FL2.Endocr Connect2026https://conductscience.org/library/papers/42370939PubMed
41,727,058High resolution spatial transcriptomic and proteomic profiling of early primate gastrulation in utero.bioRxiv2026https://conductscience.org/library/papers/41727058PubMed
41,267,116Translational biomarkers of hypoxic brain injury uncovered in CSF secreting human choroid plexus organoids.Fluids Barriers CNS2025https://conductscience.org/library/papers/41267116PubMed
40,806,316Molecular Determinants of Bone Plasticity Regeneration After Trauma: Forensic Consequences.Int J Mol Sci2025https://conductscience.org/library/papers/40806316PubMed
40,723,346The Role of TGF-β Signaling Pathway in Determining Small Ruminant Litter Size.Biology (Basel)2025https://conductscience.org/library/papers/40723346PubMed
39,795,025Potential Candidate Genes Associated with Litter Size in Goats: A Review.Animals (Basel)2025https://conductscience.org/library/papers/39795025PubMed
37,354,899Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.Dev Cell2023https://conductscience.org/library/papers/37354899PubMed
37,082,965BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage.Development2023https://conductscience.org/library/papers/37082965PubMed

1 to 10 of 80

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Genes14

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
BMP2650PubTator's text mininghttps://conductscience.org/library/genes/650NCBI Gene
BMP4652PubTator's text mininghttps://conductscience.org/library/genes/652NCBI Gene
BMP6654PubTator's text mininghttps://conductscience.org/library/genes/654NCBI Gene
BMPR1A657PubTator's text mininghttps://conductscience.org/library/genes/657NCBI Gene
BMPR1B658PubTator's text mininghttps://conductscience.org/library/genes/658NCBI Gene
INHBE83,729PubTator's text mininghttps://conductscience.org/library/genes/83729NCBI Gene
SMAD14,086PubTator's text mininghttps://conductscience.org/library/genes/4086NCBI Gene
SMAD24,087PubTator's text mininghttps://conductscience.org/library/genes/4087NCBI Gene
SMAD34,088PubTator's text mininghttps://conductscience.org/library/genes/4088NCBI Gene

1 to 10 of 14

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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