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Gene · 657

BMPR1A: bone morphogenetic protein receptor type 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BMPR1A: bone morphogenetic protein receptor type 1A. Genes, record 657. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/657

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Gene

Symbol
BMPR1A
HGNC
Name
bone morphogenetic protein receptor type 1A
HGNC
NCBI Gene ID
657
NCBI Gene
HGNC ID
HGNC:1076
HGNC
Ensembl
ENSG00000107779
NCBI Gene
Aliases
10q23del, ACVRLK3, ALK-3, ALK3, BMPR-1A, CD292, SKR5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P36894Bone morphogenetic protein receptor type-1A53211Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439077P36894Espacenet
JP 2026004568 A2026-01-1439078P36894Espacenet
EP 4650780 A22025-11-199046P36894Espacenet
US 12421295 B22025-09-2322P36894Espacenet
JP 2025529142 A2025-09-04585P36894Espacenet
US 12371689 B22025-07-29585P36894Espacenet
JP 2025517970 A2025-06-129046P36894Espacenet
JP 2025062604 A2025-04-149330P36894Espacenet
JP 2025506727 A2025-03-131P36894Espacenet
US 12240887 B22025-03-0474P36894Espacenet

1 to 10 of 63

See all 63 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIBOTERMIN ALFACHEMBL2109171Bone morphogenetic protein receptor type-1A agonistAGONISTChEMBL
EPTOTERMIN ALFACHEMBL2108594Bone morphogenetic protein receptor type-1A agonistAGONISTChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05911477DIBOTERMIN ALFAClinicalTrials.gov
NCT01133613EPTOTERMIN ALFAPHASE1ClinicalTrials.gov
NCT01111045EPTOTERMIN ALFAPHASE2ClinicalTrials.gov
NCT00456157EPTOTERMIN ALFAPHASE1ClinicalTrials.gov

NIH grants2,225

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBMPR1A papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
P30CA016672Cancer Center Support Grant152025
P30CA015704Cancer Center Support Grant132025
P30CA068485Cancer Center Support Grant132025
P30CA006973Regional Oncology Research Center102025
P30CA016058Cancer Center Support Grant102025
P30DK058404Molecular and Cellular Basis for Digestive Diseases82025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)72025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)72025
P30CA054174Mays Cancer Center at UT Health SA62025

1 to 10 of 2,225Source NIH's project files

See all 2,225 nih grants

Papers3,264

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Retraction: ALK3-SMAD1/5 signaling mediates the BMP2-induced decrease in PGE2 production in human endometrial stromal cells and decidual stromal cells.Front Cell Dev Biol202642787304PubTator, text miningPubMed
CK2.1 Activates Chondrogenesis by Regulation of the p38 Mitogen-Activated Protein Kinase Pathway.Kinases Phosphatases202642769872PubTator, text miningPubMed
Hypericin attenuates pathological scarring through concurrent modulation of transforming growth factor-β1 and bone morphogenetic protein 2 signaling in vitro and in vivo.Phytomedicine202642762718PubTator, text miningPubMed
Familial Juvenile Polyposis Syndrome: A Case Report of a Cosegregation of SMAD4 Germline Pathogenic Variant c.403C>T and Review of the Literature.Case Rep Surg202642670380PubTator, text miningPubMed
Case Report: BMPR1A and BARD1 variants: first case identified in a Colombian family with juvenile polyposis syndrome.Front Oncol202642661631PubTator, text miningPubMed
Prenatal diagnosis of a familial 10q22.3q23.2 microduplication encompassing NRG3, GRID1, BMPR1A and GLUD1 associated with no apparently phenotypic abnormality in the family carrier members.Taiwan J Obstet Gynecol202642642123PubTator, text miningPubMed
Links of BMP4, BMPR1A, and GREM1 expression in subcutaneous and visceral adipose tissue with metabolic syndrome and their regulation by insulin and weight loss.Pol Arch Intern Med202642639863PubTator, text miningPubMed
Juvenile Polyposis Syndrome in a Post-Fontan Adolescent With Tetralogy of Fallot: A Rare Association With Important Cancer Risk and Developmental Overlap.ACG Case Rep J202642583663PubTator, text miningPubMed
Proteomic characterization of airway obstruction-associated proteins in non-smoking lung adenocarcinoma.Clin Transl Oncol202642472420PubTator, text miningPubMed
PAPSS2-mediated BMPR1A sulfation in stromal cells regulating endometrial decidualization via autophagy.Hum Reprod202642421304PubTator, text miningPubMed

1 to 10 of 3,264

See all 3,264 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/657

GET https://conductscience.org/api/genes/v1/657/patents?page=2