Paper · 42902383

Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma.

Celesia A and 13 others. Mol Cancer, 2026.

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ConductScience Library. Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma. Papers, record 42902383. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42902383

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma.
Journal: Mol Cancer
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42902383/
DOI: https://doi.org/10.1186/s12943-026-02746-y
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13685200/
The journal: https://conductscience.org/library/journal-index/101147698
Revised in PubMed: 2026-10-23

Source PubMed

Authors14

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Celesia A	Adriana
2	Piccoli F	Filippo
3	Wang T	Tian
4	Hu Y	Yushu
5	Danzi F	Federica
6	Aparo A	Antonino
7	Cisterna B	Barbara
8	Pacchiana R	Raffaella
9	Poles M	Maria
10	Scupoli MT	Maria Teresa

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Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Ferroptosis	Major topic
Tumor Suppressor Protein p53	Major topic
Carcinoma, Pancreatic Ductal	Major topic
Pancreatic Neoplasms	Major topic
Mutation	Major topic
Humans
Animals
Mice
Metabolic Reprogramming
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Mitochondria
Reactive Oxygen Species
Glycolysis

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Stated by
21509	Fondazione AIRC per la ricerca sul cancro ETS	PubMed
27080	Fondazione AIRC per la ricerca sul cancro ETS	PubMed
PE00000019, CUP: B33C22001030006	PNRR "HEAL ITALIA - Health Extended Alliance for Innovative Therapies, Advanced Lab-research, and Integrated Approaches of Precision Medicine	PubMed
PE00000006 (CUP: B33C22001060002)	PNRR project MNESYS	PubMed
FIS3 FIS-2024-04982	Italian Ministry of University and Research	PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References60

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	35,484,422	MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.	Nat Cancer	2022	https://conductscience.org/library/papers/35484422	PubMed
2	36,003,910	The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease.	Front Cardiovasc Med	2022	https://conductscience.org/library/papers/36003910	PubMed
3	40,182,139	Pancreatic Cancer: Pathogenesis and Clinical Studies.	MedComm (2020)	2025	https://conductscience.org/library/papers/40182139	PubMed
4	25,719,666	Whole genomes redefine the mutational landscape of pancreatic cancer.	Nature	2015	https://conductscience.org/library/papers/25719666	PubMed
5	41,358,172	Pancreatic cancer in 2025: Have we found a solution?	World J Gastroenterol	2025	https://conductscience.org/library/papers/41358172	PubMed
6	35,398,344	Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.	Gastroenterology	2022	https://conductscience.org/library/papers/35398344	PubMed
7	25,402,683	Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.	Nat Cell Biol	2014	https://conductscience.org/library/papers/25402683	PubMed
8	35,169,856	Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation.	Mol Med Rep	2022	https://conductscience.org/library/papers/35169856	PubMed
9	39,774,001	Multidimensional analyses identify genes of high priority for pancreatic cancer research.	JCI Insight	2025	https://conductscience.org/library/papers/39774001	PubMed
10	40,614,202	TP53 missense-specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer.	Sci Adv	2025	https://conductscience.org/library/papers/40614202	PubMed

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Cited by0

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None in this release.

Genes0

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None in this release.

Drugs0

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None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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