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Paper · 25719666

Whole genomes redefine the mutational landscape of pancreatic cancer.

Waddell N and 89 others. Nature, 2015. Cited by 2,123 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Whole genomes redefine the mutational landscape of pancreatic cancer. Papers, record 25719666. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25719666

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Whole genomes redefine the mutational landscape of pancreatic cancer.
PubMed
Journal
Nature
PubMed
Year
2015
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
2,123
iCite
Relative citation ratio, by iCite
62.5
iCite
Revised in PubMed
2026-05-18
PubMed

Authors90

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Waddell NNicola
2Pajic MMarina
3Patch AMAnn-Marie
4Chang DKDavid K
5Kassahn KSKarin S
6Bailey PPeter
7Johns ALAmber L
8Miller DDavid
9Nones KKatia
10Quek KKelly

1 to 10 of 90Source PubMed

See all 90 authors

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA Mutational AnalysisMajor topic
Genome, HumanMajor topic
GenomicsMajor topic
MutationMajor topic
Pancreatic NeoplasmsMajor topic
Adenocarcinoma
Animals
Carcinoma, Pancreatic Ductal
DNA Repair
Female
Genes, BRCA1
Genes, BRCA2
Genetic Markers
Genomic Instability
Genotype
Humans
Mice
Platinum
Point Mutation
Poly(ADP-ribose) Polymerase Inhibitors
Xenograft Model Antitumor Assays

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
103721Wellcome TrustUnited KingdomPubMedPubMed
P50 CA62924NCI NIH HHSUnited StatesP50CA062924PubMed and NIHNIH RePORTER
C29717/A17263Cancer Research UKUnited KingdomPubMedPubMed
C596/A18076Cancer Research UKUnited KingdomPubMedPubMed
17263Cancer Research UKUnited KingdomPubMedPubMed
P50 CA062924NCI NIH HHSUnited StatesP50CA062924PubMed and NIHNIH RePORTER
P30 CA006973NCI NIH HHSUnited StatesP30CA006973PubMed and NIHNIH RePORTER

Trials4

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT02869802Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic AnalysisBackgroundClinicalTrials.gov
NCT05556603AssesSment of Early-deteCtion basEd oN liquiD Biopsy in PANCEATIC Cancer (ASCEND-PANCREATIC)BackgroundClinicalTrials.gov
NCT06574620Using Tumour DNA and Proteins to Better Understand How Pancreatic Cancer Responds to TreatmentBackgroundClinicalTrials.gov
NCT06736717Onvansertib in Combination With NALIRIFOX for First Line Treatment of Advanced Pancreatic CancerBackgroundClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,577,041Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer.J Clin Oncol2007https://conductscience.org/library/papers/17577041PubMed
222,315,472A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.Gut2012https://conductscience.org/library/papers/22315472PubMed
317,952,125Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays.Oncogene2008https://conductscience.org/library/papers/17952125PubMed
418,373,843Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer.BMC Cancer2008https://conductscience.org/library/papers/18373843PubMed
518,495,755A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions.FASEB J2008https://conductscience.org/library/papers/18495755PubMed
618,772,397Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.Science2008https://conductscience.org/library/papers/18772397PubMed
719,097,774New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).Eur J Cancer2009https://conductscience.org/library/papers/19097774PubMed
822,421,440Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22421440PubMed
922,622,578Melanoma genome sequencing reveals frequent PREX2 mutations.Nature2012https://conductscience.org/library/papers/22622578PubMed
1022,608,084Mutational processes molding the genomes of 21 breast cancers.Cell2012https://conductscience.org/library/papers/22608084PubMed

1 to 10 of 53

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Cited by1,580

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,123 citations.

PMIDTitleJournalYearIn PapersSource
42,979,040Naringenin in pancreatic cancer: emerging evidence on the tumor immune-stromal microenvironment, immunometabolic reprogramming, microbiota-host crosstalk, and therapeutic resistance.Front Immunol2026https://conductscience.org/library/papers/42979040PubMed
42,975,825LC-WGS-based Chromosomal Instability Analysis of EUS-FNA Specimens for Diagnosing Solid Pancreatic Lesions.Ann Surg Oncol2026https://conductscience.org/library/papers/42975825PubMed
42,927,598Peripheral immune tolerance as a driver of tumor immune escape and therapy resistance.Clin Transl Oncol2026https://conductscience.org/library/papers/42927598PubMed
42,926,530The impact of sex and ancestry on the molecular landscape of pancreatic adenocarcinoma.bioRxiv2026https://conductscience.org/library/papers/42926530PubMed
42,922,762Paternal regulation of H3K4 methylation supports tumor suppressor networks in mammals intergenerationally.bioRxiv2026https://conductscience.org/library/papers/42922762PubMed
42,902,383Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma.Mol Cancer2026https://conductscience.org/library/papers/42902383PubMed
42,883,798p38α Signaling Is Associated with Pancreatic Ductal Adenocarcinoma Progression and Represents a Potential Therapeutic Vulnerability.Int J Mol Sci2026https://conductscience.org/library/papers/42883798PubMed
42,869,988Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression.Nat Genet2026https://conductscience.org/library/papers/42869988PubMed
42,846,490Transcriptomic buffering detection: a computational approach to identifying essential gene dependencies in pancreatic cancer.Bioinform Adv2026https://conductscience.org/library/papers/42846490PubMed
42,793,040The Significance of Somatic Variants Involved in the Development of Pancreatic Cancer in Patients with HBOC-Associated Germline Variants.Genes (Basel)2026https://conductscience.org/library/papers/42793040PubMed

1 to 10 of 1,580

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Genes33

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ARID1A8,289PubTator's text mininghttps://conductscience.org/library/genes/8289NCBI Gene
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
COL11A21,302PubTator's text mininghttps://conductscience.org/library/genes/1302NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene
FANCM57,697PubTator's text mininghttps://conductscience.org/library/genes/57697NCBI Gene
FGFR12,260PubTator's text mininghttps://conductscience.org/library/genes/2260NCBI Gene

1 to 10 of 33

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE61502

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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