Paper · 42979327

Concurrent loss of RB1 facilitates EGFR-TKI resistance in EGFR-mutant lung cancer by modulating histone crotonylation.

Chen S and 10 others. Acta Pharm Sin B, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Concurrent loss of RB1 facilitates EGFR-TKI resistance in EGFR-mutant lung cancer by modulating histone crotonylation. Papers, record 42979327. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42979327

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Title: Concurrent loss of RB1 facilitates EGFR-TKI resistance in EGFR-mutant lung cancer by modulating histone crotonylation.
Journal: Acta Pharm Sin B
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42979327/
DOI: https://doi.org/10.1016/j.apsb.2026.08.007
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13730233/
The journal: https://conductscience.org/library/journal-index/101600560
Revised in PubMed: 2026-11-05

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Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Chen S	Sihong
2	Wang X	Xiaoyuan
3	Xuan Q	Qihao
4	Liu C	Chang
5	Su Y	Youwei
6	Liu Z	Zongang
7	Jia L	Lina
8	Ren Y	Yi
9	Cui W	Wei
10	Fan X	Xinyu

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Comments and corrections0

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References65

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	25,818,647	Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.	Mol Cell	2015	https://conductscience.org/library/papers/25818647	PubMed
2	29,596,544	Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With EGFR-Mutant Advanced Non-Small Cell Lung Cancer.	JAMA Oncol	2018	https://conductscience.org/library/papers/29596544	PubMed
3	32,289,276	Targeting the MAPK Pathway in KRAS-Driven Tumors.	Cancer Cell	2020	https://conductscience.org/library/papers/32289276	PubMed
4	36,970,205	Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer.	Acta Pharm Sin B	2023	https://conductscience.org/library/papers/36970205	PubMed
5	42,368,588	Organoids, organ-on-a-chip, and microtumors: Biomimetic 3D tumor models advancing drug development and precision medicine.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42368588	PubMed
6	33,848,425	Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation.	Annu Rev Biochem	2021	https://conductscience.org/library/papers/33848425	PubMed
7	21,925,322	Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.	Cell	2011	https://conductscience.org/library/papers/21925322	PubMed
8	15,313,890	SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.	Cancer Res	2004	https://conductscience.org/library/papers/15313890	PubMed
9	42,368,576	Lactate metabolism and epigenetic reprogramming drive c-KIT hyperactivation to mediate Gilteritinib resistance: Rationale for c-KIT degraders over kinase inhibitors.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42368576	PubMed
10	28,724,430	EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer.	Mol Cancer	2017	https://conductscience.org/library/papers/28724430	PubMed

1 to 10 of 65

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Cited by0

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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