Paper · 15313890

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.

Tsavachidou D and 6 others. Cancer Res, 2004. Cited by 98 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant. Papers, record 15313890. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/15313890

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.; PubMed
Journal: Cancer Res; PubMed
Year: 2004; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/15313890/; PubMed
DOI: https://doi.org/10.1158/0008-5472.can-04-1669; PubMed
The journal: https://conductscience.org/library/journal-index/2984705R; PubMed
Citations, by iCite: 98; iCite
Relative citation ratio, by iCite: 1.64; iCite
Revised in PubMed: 2014-11-20; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Tsavachidou D	Dimitra
2	Coleman ML	Mathew L
3	Athanasiadis G	Galene
4	Li S	Shuixing
5	Licht JD	Jonathan D
6	Olson MF	Michael F
7	Weber BL	Barbara L

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Melanocytes	Major topic
Melanoma	Major topic
Mitogen-Activated Protein Kinases	Major topic
Proteins	Major topic
Proto-Oncogene Proteins c-raf	Major topic
ras Proteins	Major topic
Cell Line, Tumor
Gene Expression Profiling
Humans
Intracellular Signaling Peptides and Proteins
MAP Kinase Signaling System
Membrane Proteins
Mutation
Oligonucleotide Array Sequence Analysis
Protein Biosynthesis
Proto-Oncogene Proteins B-raf
RNA, Small Interfering
Transfection

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA030721-01A1	NCI NIH HHS	United States		PubMed	PubMed
CA59998	NCI NIH HHS	United States	R01CA059998	PubMed and NIH	NIH RePORTER
			R01CA030721	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by62

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 98 citations.

PMID	Title	Journal	Year	In Papers	Source
42,979,327	Concurrent loss of RB1 facilitates EGFR-TKI resistance in EGFR-mutant lung cancer by modulating histone crotonylation.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42979327	PubMed
39,494,610	Model ensembling as a tool to form interpretable multi-omic predictors of cancer pharmacosensitivity.	Brief Bioinform	2024	https://conductscience.org/library/papers/39494610	PubMed
38,012,755	Therapeutic effect and transcriptome-methylome characteristics of METTL3 inhibition in liver hepatocellular carcinoma.	Cancer Cell Int	2023	https://conductscience.org/library/papers/38012755	PubMed
37,845,209	TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling.	Cell Death Discov	2023	https://conductscience.org/library/papers/37845209	PubMed
37,444,145	Examining the Effects of Gestational Physical Activity and Hofbauer Cell Polarization on Angiogenic Factors.	Int J Environ Res Public Health	2023	https://conductscience.org/library/papers/37444145	PubMed
36,765,910	ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant Melanomas by Stabilizing RAF/MYC/ETS1 and Promoting RAF Homodimerization.	Cancers (Basel)	2023	https://conductscience.org/library/papers/36765910	PubMed
36,139,698	RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines.	Cancers (Basel)	2022	https://conductscience.org/library/papers/36139698	PubMed
35,707,123	The DNA methylation landscape of five pediatric-tumor types.	PeerJ	2022	https://conductscience.org/library/papers/35707123	PubMed
35,116,291	The role of TRIM51 as a multipurpose biomarker in melanoma.	Transl Cancer Res	2021	https://conductscience.org/library/papers/35116291	PubMed
34,048,471	Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma.	PLoS One	2021	https://conductscience.org/library/papers/34048471	PubMed

1 to 10 of 62

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Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
BRAF	673	PubTator's text mining	https://conductscience.org/library/genes/673	NCBI Gene
MAPK1	5,594	PubTator's text mining	https://conductscience.org/library/genes/5594	NCBI Gene
RAF1	5,894	PubTator's text mining	https://conductscience.org/library/genes/5894	NCBI Gene
SPRY2	10,253	PubTator's text mining	https://conductscience.org/library/genes/10253	NCBI Gene
SPRY4	81,848	PubTator's text mining	https://conductscience.org/library/genes/81848	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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