Paper · 4384885

Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin.

Pearse AG. Proc R Soc Lond B Biol Sci, 1968. Cited by 568 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin. Papers, record 4384885. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4384885

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin.; PubMed
Journal: Proc R Soc Lond B Biol Sci; PubMed
Year: 1968; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4384885/; PubMed
DOI: https://doi.org/10.1098/rspb.1968.0025; PubMed
The journal: https://conductscience.org/library/journal-index/7505889; PubMed
Citations, by iCite: 568; iCite
Revised in PubMed: 2018-12-12; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Pearse AG	A G

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Islets of Langerhans	Major topic
Parathyroid Glands	Major topic
Pituitary Gland	Major topic
Stomach	Major topic
Thyroid Gland	Major topic
Animals
Calcitonin
Dogs
Guinea Pigs
Histocytochemistry
Hormones
Microscopy, Electron
Rats
Swine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by124

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 568 citations.

PMID	Title	Journal	Year	In Papers	Source
42,058,020	Brain neurovascular unit biomarkers: a hypothesis-driven paradigm to advance understanding of post-cardiac arrest cerebral injury.	Ann Intensive Care	2026	https://conductscience.org/library/papers/42058020	PubMed
35,821,751	Pulmonary Neuroendocrine Cells and Small Cell Lung Carcinoma: Immunohistochemical Study Focusing on Mechanisms of Neuroendocrine Differentiation.	Acta Histochem Cytochem	2022	https://conductscience.org/library/papers/35821751	PubMed
32,426,489	Local sympathetic innervations modulate the lung innate immune responses.	Sci Adv	2020	https://conductscience.org/library/papers/32426489	PubMed
29,915,166	Unusual Sites of High-Grade Neuroendocrine Carcinomas: A Case Series and Review of the Literature.	Am J Case Rep	2018	https://conductscience.org/library/papers/29915166	PubMed
29,593,561	Reciprocal Interactions of Mitochondria and the Neuroimmunoendocrine System in Neurodegenerative Disorders: An Important Role for Melatonin Regulation.	Front Physiol	2018	https://conductscience.org/library/papers/29593561	PubMed
29,580,839	The now and then of gut-brain signaling.	Brain Res	2018	https://conductscience.org/library/papers/29580839	PubMed
29,077,690	Small-cell lung cancer: what we know, what we need to know and the path forward.	Nat Rev Cancer	2017	https://conductscience.org/library/papers/29077690	PubMed
27,493,881	On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited.	Eur Thyroid J	2016	https://conductscience.org/library/papers/27493881	PubMed
25,894,842	Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis.	PLoS One	2015	https://conductscience.org/library/papers/25894842	PubMed
24,756,777	C and APUD cells and endocrine tumours. Pearse's laboratory in the years 1965-1969: a personal recollection.	Endocr Pathol	2014	https://conductscience.org/library/papers/24756777	PubMed

1 to 10 of 124

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
CALCA	796	PubTator's text mining	https://conductscience.org/library/genes/796

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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