Paper · 4530276

A limited number of globin genes in human DNA.

Gambino R and 5 others. Proc Natl Acad Sci U S A, 1974. Cited by 29 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A limited number of globin genes in human DNA. Papers, record 4530276. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4530276

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A limited number of globin genes in human DNA.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1974; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4530276/; PubMed
DOI: https://doi.org/10.1073/pnas.71.10.3966; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC434307/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 29; iCite
Relative citation ratio, by iCite: 0.83; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Gambino R	R
2	Kacian D	D
3	O'Donnell J	J
4	Ramirez F	F
5	Marks PA	P A
6	Bank A	A

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA	Major topic
Genes	Major topic
Globins	Major topic
Base Sequence
Centrifugation, Density Gradient
Chromatography
Haploidy
Humans
Hydroxyapatites
Kinetics
Nucleic Acid Hybridization
RNA, Messenger
Spleen
Thalassemia

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,291,998	Isolation of deoxyribonucleic acid from mammalian tissues.	Biochem J	1967	https://conductscience.org/library/papers/4291998	PubMed
2	4,874,239	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	Science	1968	https://conductscience.org/library/papers/4874239	PubMed
3	5,248,810	Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin.	Proc Natl Acad Sci U S A	1968	https://conductscience.org/library/papers/5248810	PubMed
4	5,540,329	Silent hemoglobin alpha genes in apes: potential source of thalassemia.	Science	1971	https://conductscience.org/library/papers/5540329	PubMed
5	4,932,893	DNA-RNA hybridization in vast DNA excess.	Nat New Biol	1971	https://conductscience.org/library/papers/4932893	PubMed
6	5,096,528	Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes.	J Clin Invest	1971	https://conductscience.org/library/papers/5096528	PubMed
7	5,129,324	Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia.	J Clin Invest	1971	https://conductscience.org/library/papers/5129324	PubMed
8	4,333,043	In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer).	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4333043	PubMed
9	4,334,193	In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA.	Nat New Biol	1972	https://conductscience.org/library/papers/4334193	PubMed
10	4,334,194	In vitro synthesis of DNA components of human genes for globins.	Nat New Biol	1972	https://conductscience.org/library/papers/4334194	PubMed

1 to 10 of 22

See all 22 references

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 29 citations.

PMID	Title	Journal	Year	In Papers	Source
1,071,439	Study of markers of human erythroid differentiation in hybrid cells.	In Vitro	1976	https://conductscience.org/library/papers/1071439	PubMed
1,055,426	Relative numbers of human globin genes assayed with purified alpha and beta complementary human DNA.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1055426	PubMed
993,355	Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA.	J Clin Invest	1976	https://conductscience.org/library/papers/993355	PubMed
815,907	No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA.	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/815907	PubMed
438,334	Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore.	J Clin Invest	1979	https://conductscience.org/library/papers/438334	PubMed
274,714	Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/274714	PubMed
66,681	Human placental lactogen mRNA and its structural genes during pregnancy: quantitation with a complementary DNA.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/66681	PubMed
49,057	Human globin gene analysis for a patient with beta-o/delta beta-thalassemia.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/49057	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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