Paper · 438334
Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore.
Ramirez F and 11 others. J Clin Invest, 1979. Cited by 18 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore. Papers, record 438334. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/438334
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Publication types
- Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
- PubMed
Topics13
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA | Major topic |
| Globins | Major topic |
| Hemoglobins, Abnormal | Major topic |
| RNA, Messenger | Major topic |
| Adolescent | |
| Child, Preschool | |
| Homozygote | |
| Humans | |
| Male | |
| Nucleic Acid Denaturation | |
| Nucleic Acid Hybridization | |
| Protein Biosynthesis | |
| Transcription, Genetic |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References39
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 14,284,319 | ABNORMAL HUMAN HEMOGLOBINS. X. A STUDY OF HEMOGLOBIN LEPORE BOSTON. | Biochim Biophys Acta | 1965 | https://conductscience.org/library/papers/14284319 | PubMed |
| 2 | 14,254,255 | STUDIES ON HEMOGLOBIN BIOSYNTHESIS: ASYNCHRONOUS SYNTHESIS OF HEMOGLOBIN A AND HEMOGLOBIN A2 BY ERYTHROCYTE PRECURSORS. | J Clin Invest | 1965 | https://conductscience.org/library/papers/14254255 | PubMed |
| 3 | 13,968,954 | The fusion of two peptide chains in hemoglobin Lepore and its interpretation as a genetic deletion. | Proc Natl Acad Sci U S A | 1962 | https://conductscience.org/library/papers/13968954 | PubMed |
| 4 | 9,762,093 | Quantitation of human globin chain synthesis by cellulose acetate electrophoresis. | Anal Biochem | 1978 | https://conductscience.org/library/papers/9762093 | PubMed |
| 5 | 687,828 | Absence of beta mRNA in beta0-thalassemia in Kurdish Jews. | Blood | 1978 | https://conductscience.org/library/papers/687828 | PubMed |
| 6 | 699,038 | Organization of human delta--and beta-globin genes in cellular DNA and the presence of intragenic inserts. | Cell | 1978 | https://conductscience.org/library/papers/699038 | PubMed |
| 7 | 274,720 | The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/274720 | PubMed |
| 8 | 274,714 | Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/274714 | PubMed |
| 9 | 273,235 | Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/273235 | PubMed |
| 10 | 597,859 | The rabbit beta-globin gene contains a large large insert in the coding sequence. | Cell | 1977 | https://conductscience.org/library/papers/597859 | PubMed |
1 to 10 of 39
See all 39 referencesCited by5
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 18 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 24,052,746 | Molecular Diagnostics of β-Thalassemia. | Balkan J Med Genet | 2012 | https://conductscience.org/library/papers/24052746 | PubMed |
| 7,263,864 | Localization of the site of recombination in formation of the Lepore Boston globin gene. | J Clin Invest | 1981 | https://conductscience.org/library/papers/7263864 | PubMed |
| 6,407,302 | The thalassemias: molecular mechanisms of human genetic disease. | Am J Hum Genet | 1983 | https://conductscience.org/library/papers/6407302 | PubMed |
| 6,255,309 | The molecular basis of disorders of human hemoglobin synthesis. | Mol Cell Biochem | 1980 | https://conductscience.org/library/papers/6255309 | PubMed |
| 2,999,704 | DNA sequences regulating human beta globin gene expression. | Nucleic Acids Res | 1985 | https://conductscience.org/library/papers/2999704 | PubMed |
Genes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| HBA2 | 3,040 | PubTator's text mining | https://conductscience.org/library/genes/3040 | NCBI Gene |
| HBB | 3,043 | PubTator's text mining | https://conductscience.org/library/genes/3043 | NCBI Gene |
| HBD | 3,045 | PubTator's text mining | https://conductscience.org/library/genes/3045 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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