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Paper4579014

Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.

Chiller JM and 3 others. Proc Natl Acad Sci U S A, 1973. Cited by 192 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity. Papers, record 4579014. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4579014

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1973
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
192
iCite
Relative citation ratio, by iCite
5.18
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chiller JMJ M
2Skidmore BJB J
3Morrison DCD C
4Weigle WOW O

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adjuvants, ImmunologicMajor topic
LipopolysaccharidesMajor topic
MitogensMajor topic
Polysaccharides, BacterialMajor topic
Animals
Antibody Formation
B-Lymphocytes
Escherichia coli
Immune Tolerance
Immunization
Lymphocyte Activation
Mice
Mice, Inbred A
Salmonella
Serum Albumin, Bovine
Structure-Activity Relationship
T-Lymphocytes

Source PubMed

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,023,169Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts.J Immunol1972https://conductscience.org/library/papers/5023169PubMed
25,926,455Cytodynamics of the distinctive immune response produced in regional lymph nodes by Salmonella somatic polysaccharide.J Immunol1966https://conductscience.org/library/papers/5926455PubMed
34,170,425A modification of the hemolytic plaque assay for use with protein antigens.J Immunol1968https://conductscience.org/library/papers/4170425PubMed
45,804,498A new method for the extraction of R lipopolysaccharides.Eur J Biochem1969https://conductscience.org/library/papers/5804498PubMed
54,874,538Regulatory effect of antibody on the immune response.Adv Immunol1968https://conductscience.org/library/papers/4874538PubMed
614,265,747ACTINOMYCIN SENSITIVITY IN ESCHERICHIA COLI PRODUCED BY EDTA.Biochem Biophys Res Commun1965https://conductscience.org/library/papers/14265747PubMed
75,285,341Endotoxin and double stranded RNA render macrophages cytotoxic.Nat New Biol1971https://conductscience.org/library/papers/5285341PubMed
85,010,393Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin.J Immunol1972https://conductscience.org/library/papers/5010393PubMed
913,957,684Plaque formation in agar by single antibody-producing cells.Science1963https://conductscience.org/library/papers/13957684PubMed
1014,139,023ENHANCEMENT OF THE PRIMARY ANTIBODY RESPONSE TO PARTICULATE ANTIGENS BY SIMPLE LIPIDS.J Immunol1964https://conductscience.org/library/papers/14139023PubMed
116,034,749Immunization of dissociated spleen cell cultures from normal mice.J Exp Med1967https://conductscience.org/library/papers/6034749PubMed
125,069,711Nature and linkages of the fatty acids present in the lipid-A component of Salmonella lipopolysaccharides.Eur J Biochem1972https://conductscience.org/library/papers/5069711PubMed
135,924,622The adjuvant activity of aliphatic nitrogenous bases.Immunology1966https://conductscience.org/library/papers/5924622PubMed
144,567,119Biological activities of lipid A complexed with bovine-serum albumin.Eur J Biochem1972https://conductscience.org/library/papers/4567119PubMed
1516,557,702Specific inhibition of endotoxin coating of red cells by a human erythrocyte membrane component.Infect Immun1970https://conductscience.org/library/papers/16557702PubMed
164,120,288Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).J Exp Med1973https://conductscience.org/library/papers/4120288PubMed
174,559,167Selective induction of DNA synthesis in T and B lymphocytes.Cell Immunol1972https://conductscience.org/library/papers/4559167PubMed
184,563,346Lipopolysaccharide can substitute for helper cells in the antibody response in vitro.Eur J Immunol1972https://conductscience.org/library/papers/4563346PubMed
194,557,773Immune response to a hapten coupled to a nonimmunogenic carrier. Influence of lipopolysaccharide.J Exp Med1972https://conductscience.org/library/papers/4557773PubMed
204,103,727Cellular events during induction of immunologic unresponsiveness in adult mice.J Immunol1971https://conductscience.org/library/papers/4103727PubMed

See all 27 references

Cited by52

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 192 citations.

PMIDTitleJournalYearIn PapersSource
33,274,243The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis.J Immunol Res2020https://conductscience.org/library/papers/33274243PubMed
25,563,849Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection.Sci Rep2015https://conductscience.org/library/papers/25563849PubMed
7,923,049Molecular adjuvants and immunomodulators: new approaches to immunization.Clin Microbiol Rev1994https://conductscience.org/library/papers/7923049PubMed
7,042,572Transfer of Salmonella resistance and delayed hypersensitivity with murine-derived transfer factor.Infect Immun1982https://conductscience.org/library/papers/7042572PubMed
7,037,619In vivo activation of mouse spleen lymphocytes by lipid A in carrier-free form.Immunology1982https://conductscience.org/library/papers/7037619PubMed
7,000,681Effect of lipid A-associated protein and lipid A on the expression of lipopolysaccharide activity. I. Immunological activity.Immunology1980https://conductscience.org/library/papers/7000681PubMed
6,991,433Breast milk lymphocyte response to K1 antigen of Escherichia coli.Infect Immun1980https://conductscience.org/library/papers/6991433PubMed
6,982,864In vitro studies on the adjuvanticity of Brucella fractions.Infect Immun1982https://conductscience.org/library/papers/6982864PubMed
6,980,191Lipopolysaccharides from Bacteroides fragilis are mitogenic for spleen cells from endotoxin responder and nonresponder mice.Infect Immun1982https://conductscience.org/library/papers/6980191PubMed
6,968,810Late clonal selection and expansion of the TEPC-15 germ-line specificity.J Exp Med1980https://conductscience.org/library/papers/6968810PubMed
6,715,043Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A.Infect Immun1984https://conductscience.org/library/papers/6715043PubMed
6,348,772Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6348772PubMed
6,193,755Protective activities of ribosomal ribonucleic acid and lipopolysaccharide of Pseudomonas aeruginosa: a comparative study.Antonie Van Leeuwenhoek1983https://conductscience.org/library/papers/6193755PubMed
4,610,079Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response.J Exp Med1974https://conductscience.org/library/papers/4610079PubMed
4,607,609Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides.J Exp Med1974https://conductscience.org/library/papers/4607609PubMed
4,544,246Induction of IgG by lipid A in the newborn mouse.J Exp Med1974https://conductscience.org/library/papers/4544246PubMed
4,543,458Specific murine B-cell activation by synthetic single-and double-stranded polynucleotides.J Exp Med1973https://conductscience.org/library/papers/4543458PubMed
4,378,413Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins).J Exp Med1974https://conductscience.org/library/papers/4378413PubMed
4,372,628Collagenase production by endotoxin-activated macrophages.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4372628PubMed
4,138,849Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones to lipopolysaccharides.J Exp Med1974https://conductscience.org/library/papers/4138849PubMed

See all 52 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
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  • PubTator 3Public domain
  • UniProtCC BY 4.0
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  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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