Paper · 46281

Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide.

Verma IM. J Virol, 1975. Cited by 49 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide. Papers, record 46281. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/46281

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide.; PubMed
Journal: J Virol; PubMed
Year: 1975; PubMed
Publication types: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/46281/; PubMed
DOI: https://doi.org/10.1128/jvi.15.1.121-126.1975; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC354425/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 49; iCite
Relative citation ratio, by iCite: 1.17; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Verma IM	I M

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Avian Leukosis Virus	Major topic
Avian Sarcoma Viruses	Major topic
Peptides	Major topic
RNA-Directed DNA Polymerase	Major topic
Ribonucleases	Major topic
Cell-Free System
Chromatography
Guanosine Triphosphate
Molecular Weight
Mutation
Polynucleotides
Temperature
Tritium

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References12

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,122,425	Characterization of two conditional early mutants of Rous sarcoma virus.	Virology	1973	https://conductscience.org/library/papers/4122425	PubMed
2	4,132,918	Hamster leukemia virus: lack of endogenous DNA synthesis and unique structure of its DNA polymerase.	J Virol	1974	https://conductscience.org/library/papers/4132918	PubMed
3	4,136,633	Different mode of action of ribonuclease H in purified alpha and alpha beta ribonucleic acid-directed deoxyribonucleic acid polymerase from avian myeloblastosis virus.	J Biol Chem	1974	https://conductscience.org/library/papers/4136633	PubMed
4	4,137,615	DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile.	Nature	1974	https://conductscience.org/library/papers/4137615	PubMed
5	4,317,920	Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion.	Proc Natl Acad Sci U S A	1970	https://conductscience.org/library/papers/4317920	PubMed
6	4,119,223	A single subunit from avian myeloblastosis virus with both RNA-directed DNA polymerase and ribonuclease H activity.	Proc Natl Acad Sci U S A	1973	https://conductscience.org/library/papers/4119223	PubMed
7	4,334,983	Purification of the DNA polymerase of avian myeloblastosis virus.	Biochim Biophys Acta	1971	https://conductscience.org/library/papers/4334983	PubMed
8	4,337,614	Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus.	Biochemistry	1972	https://conductscience.org/library/papers/4337614	PubMed
9	4,344,646	Association of an endoribonuclease with the avian myeloblastosis virus deoxyribonucleic acid polymerase.	J Biol Chem	1972	https://conductscience.org/library/papers/4344646	PubMed
10	4,348,509	RNA-directed DNA synthesis and RNA tumor viruses.	Adv Virus Res	1972	https://conductscience.org/library/papers/4348509	PubMed

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Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 49 citations.

PMID	Title	Journal	Year	In Papers	Source
34,900,141	M-MuLV reverse transcriptase: Selected properties and improved mutants.	Comput Struct Biotechnol J	2021	https://conductscience.org/library/papers/34900141	PubMed
30,669,277	The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda.	Viruses	2019	https://conductscience.org/library/papers/30669277	PubMed
9,621,052	Replication defect of moloney murine leukemia virus with a mutant reverse transcriptase that can incorporate ribonucleotides and deoxyribonucleotides.	J Virol	1998	https://conductscience.org/library/papers/9621052	PubMed
2,450,347	Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.	Proc Natl Acad Sci U S A	1988	https://conductscience.org/library/papers/2450347	PubMed
2,429,313	Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.	Proc Natl Acad Sci U S A	1986	https://conductscience.org/library/papers/2429313	PubMed
209,213	Genome organization of RNA tumor viruses. I. In vitro synthesis of full-genome-length single-stranded and double-stranded viral DNA transcripts.	J Virol	1978	https://conductscience.org/library/papers/209213	PubMed
81,314	Mammalian retrovirus-associated RNase H is virus coded.	J Virol	1978	https://conductscience.org/library/papers/81314	PubMed
81,313	Reverse transcriptase-associated RNase H activity. II. Inhibition by natural and synthetic RNA.	J Virol	1978	https://conductscience.org/library/papers/81313	PubMed
75,271	Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.	J Virol	1978	https://conductscience.org/library/papers/75271	PubMed
72,160	Interactions of murine leukemia virus core components: characterization of reverse transcriptase packaged in the absence of 70S genomic RNA.	J Virol	1977	https://conductscience.org/library/papers/72160	PubMed

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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