Paper · 75271

Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.

Lai MH and 1 other. J Virol, 1978. Cited by 36 papers, by iCite.

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ConductScience Library. Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity. Papers, record 75271. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75271

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.; PubMed
Journal: J Virol; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/75271/; PubMed
DOI: https://doi.org/10.1128/jvi.25.2.652-663.1978; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC353978/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 36; iCite
Relative citation ratio, by iCite: 0.81; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Lai MH	M H
2	Verma IM	I M

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Avian Leukosis Virus	Major topic
Avian Myeloblastosis Virus	Major topic
Peptides	Major topic
RNA-Directed DNA Polymerase	Major topic
Chymotrypsin
Molecular Weight
Ribonucleases

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,316,301	RNA-dependent DNA polymerase in virions of Rous sarcoma virus.	Nature	1970	https://conductscience.org/library/papers/4316301	PubMed
2	46,281	Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide.	J Virol	1975	https://conductscience.org/library/papers/46281	PubMed
3	5,432,063	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	Nature	1970	https://conductscience.org/library/papers/5432063	PubMed
4	4,326,772	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	Biochemistry	1971	https://conductscience.org/library/papers/4326772	PubMed
5	4,316,300	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	Nature	1970	https://conductscience.org/library/papers/4316300	PubMed
6	50,321	Sequence relatedness between the subunits of avian myeloblastosis virus reverse transcriptase.	J Biol Chem	1975	https://conductscience.org/library/papers/50321	PubMed
7	4,348,509	RNA-directed DNA synthesis and RNA tumor viruses.	Adv Virus Res	1972	https://conductscience.org/library/papers/4348509	PubMed
8	4,360,349	Protein iodination with solid state lactoperoxidase.	Biochemistry	1974	https://conductscience.org/library/papers/4360349	PubMed
9	4,140,514	Studies on the reverse transcriptase of RNA tumor viruses. Structural relatedness of two subunits of avian RNA tumor viruses.	Proc Natl Acad Sci U S A	1974	https://conductscience.org/library/papers/4140514	PubMed
10	5,106,387	Reversible denaturation of enzymes by sodium dodecyl sulfate.	J Biol Chem	1971	https://conductscience.org/library/papers/5106387	PubMed

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Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 36 citations.

PMID	Title	Journal	Year	In Papers	Source
6,257,933	Partial phosphorylation in vivo of the avian retrovirus pp32 DNA endonuclease.	J Virol	1980	https://conductscience.org/library/papers/6257933	PubMed
6,205,170	Murine leukemia virus mutant with a frameshift in the reverse transcriptase coding region: implications for pol gene structure.	J Virol	1984	https://conductscience.org/library/papers/6205170	PubMed
6,165,835	Virus-coded DNA endonuclease from avian retrovirus.	J Virol	1981	https://conductscience.org/library/papers/6165835	PubMed
6,157,835	Effect of p15-associated protease from an avian RNA tumor virus on avian virus-specific polyprotein precursors.	J Virol	1980	https://conductscience.org/library/papers/6157835	PubMed
6,154,149	Activation of an Mg2+-dependent DNA endonuclease of avian myeloblastosis virus alpha beta DNA polymerase by in vitro proteolytic cleavage.	J Virol	1980	https://conductscience.org/library/papers/6154149	PubMed
2,459,414	Functional organization of the murine leukemia virus reverse transcriptase: characterization of a bacterially expressed AKR DNA polymerase deficient in RNase H activity.	J Virol	1988	https://conductscience.org/library/papers/2459414	PubMed
2,452,083	Identification and characterization of HIV-specific RNase H by monoclonal antibody.	EMBO J	1988	https://conductscience.org/library/papers/2452083	PubMed
2,450,347	Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.	Proc Natl Acad Sci U S A	1988	https://conductscience.org/library/papers/2450347	PubMed
2,448,747	Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity.	Nucleic Acids Res	1988	https://conductscience.org/library/papers/2448747	PubMed
2,429,313	Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.	Proc Natl Acad Sci U S A	1986	https://conductscience.org/library/papers/2429313	PubMed

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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