Paper · 46912

The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues.

Janeway CA and 3 others. J Exp Med, 1975. Cited by 51 papers, by iCite.

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ConductScience Library. The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues. Papers, record 46912. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/46912

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues.; PubMed
Journal: J Exp Med; PubMed
Year: 1975; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/46912/; PubMed
DOI: https://doi.org/10.1084/jem.141.1.42; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2190509/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 51; iCite
Relative citation ratio, by iCite: 1.15; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Janeway CA	C A
2	Cohen BE	B E
3	Ben-Sasson SZ	S Z
4	Paul WE	W E

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Dinitrophenols	Major topic
Epitopes	Major topic
Immunity, Cellular	Major topic
T-Lymphocytes	Major topic
Tyrosine	Major topic
Albumins
Animals
Cell Migration Inhibition
Cells, Cultured
DNA
Glutamates
Guinea Pigs
Haptens
Hemocyanins
Hypersensitivity, Delayed
Lysine
Macrophages
Mercaptoethanol
Mycobacterium tuberculosis
Nitrobenzenes
Ovalbumin
Skin Tests
Tritium

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,981,513	The immunogenicity of dinitrophenyl amino acids.	J Exp Med	1969	https://conductscience.org/library/papers/4981513	PubMed
2	5,112,203	The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.	J Exp Med	1971	https://conductscience.org/library/papers/5112203	PubMed
3	4,108,379	The carrier effect in the secondary response to hapten-protein conjugates. V. Use of antilymphocyte serum to deplete animals of helper cells.	Eur J Immunol	1971	https://conductscience.org/library/papers/4108379	PubMed
4	4,108,424	Functional specificity of antigen-binding receptors of lymphocytes.	Transplant Rev	1970	https://conductscience.org/library/papers/4108424	PubMed
5	4,112,562	Antigen recognition and the immune response. Humoral and cellular immune responses to small mono- and bifunctional antigen molecules.	J Exp Med	1972	https://conductscience.org/library/papers/4112562	PubMed
6	4,116,444	Lymphocyte receptors and mechanisms of in vitro cell-mediated immune reactions.	Transplant Rev	1972	https://conductscience.org/library/papers/4116444	PubMed
7	4,395,780	Hapten competition and the nature of cell-cooperation in the antibody response.	Proc R Soc Lond B Biol Sci	1971	https://conductscience.org/library/papers/4395780	PubMed
8	4,544,193	Macrophage control of time-dependent changes in antigen sensitivity of immune T lymphocyte populations.	J Immunol	1974	https://conductscience.org/library/papers/4544193	PubMed
9	4,551,581	Depletion of antibody-forming cells and their precursors from complex lymphoid cell populations.	J Immunol	1972	https://conductscience.org/library/papers/4551581	PubMed
10	4,587,740	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	Eur J Immunol	1973	https://conductscience.org/library/papers/4587740	PubMed

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 51 citations.

PMID	Title	Journal	Year	In Papers	Source
20,617,150	Bridging innate and adaptive antitumor immunity targeting glycans.	J Biomed Biotechnol	2010	https://conductscience.org/library/papers/20617150	PubMed
15,493,260	The T-cell response to haptenated insulins. I. The proliferative response.	Immunology	1989	https://conductscience.org/library/papers/15493260	PubMed
6,602,202	Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells.	J Exp Med	1983	https://conductscience.org/library/papers/6602202	PubMed
947,646	Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens.	Clin Exp Immunol	1976	https://conductscience.org/library/papers/947646	PubMed
302,915	Primary in vitro sensitisation of human T cells.	Nature	1977	https://conductscience.org/library/papers/302915	PubMed
95,787	Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.	J Exp Med	1977	https://conductscience.org/library/papers/95787	PubMed
85,255	Recognition of antigens by T lymphocytes.	Mol Cell Biochem	1978	https://conductscience.org/library/papers/85255	PubMed
81,789	Leukocyte migration inhibition induced by the combination of drug and a liver constituent in patients with drug-induced hepatitis.	Gastroenterol Jpn	1978	https://conductscience.org/library/papers/81789	PubMed
77,841	Specificity of murine delayed-type hypersensitivity to conjugates of large or small haptens on protein carriers bearing lipid groups.	Immunology	1978	https://conductscience.org/library/papers/77841	PubMed
68,923	The immune response to oxidized ferredoxin. I. Specificity of the response to the amino terminal determinant.	Immunology	1976	https://conductscience.org/library/papers/68923	PubMed

1 to 10 of 15

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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