Paper47633
The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond.
Isenman DE and 2 others. Proc Natl Acad Sci U S A, 1975. Cited by 58 papers, by iCite.
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ConductScience Library. The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond. Papers, record 47633. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/47633
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond.
- PubMed
Topics5
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Beta-Globulins | Major topic |
| Circular Dichroism | |
| Guanidines | |
| Models, Structural | |
| Protein Conformation |
Source PubMed
References27
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 4,195,396 | Properties of halves of immunoglobulin light chains. | Proc Natl Acad Sci U S A | 1969 | https://conductscience.org/library/papers/4195396 | PubMed |
| 2 | 4,773,847 | Structure of a lambda-type Bence-Jones protein at 3.5-A resolution. | Biochemistry | 1973 | https://conductscience.org/library/papers/4773847 | PubMed |
| 3 | 4,519,624 | Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution. | Proc Natl Acad Sci U S A | 1973 | https://conductscience.org/library/papers/4519624 | PubMed |
| 4 | 4,850,521 | An atypical human immunoglobulin G with deletions in both heavy and light chains. Studies of the conformation and the in vitro recombination of the isolated subunits. | Can J Biochem | 1974 | https://conductscience.org/library/papers/4850521 | PubMed |
| 5 | 5,008,437 | Initiation of protein synthesis at an unusual position in an immunoglobulin gene? | Science | 1972 | https://conductscience.org/library/papers/5008437 | PubMed |
| 6 | 11,946,697 | A fragment corresponding to the C(H)2 region of immunoglobulin G (IgG) with complement fixing activity. | FEBS Lett | 1972 | https://conductscience.org/library/papers/11946697 | PubMed |
| 7 | 4,175,239 | Isolation and properties of a low molecular weight beta-2-globulin occurring in human biological fluids. | J Biol Chem | 1968 | https://conductscience.org/library/papers/4175239 | PubMed |
| 8 | 4,882,248 | Protein denaturation. | Adv Protein Chem | 1968 | https://conductscience.org/library/papers/4882248 | PubMed |
| 9 | 5,257,969 | The covalent structure of an entire gammaG immunoglobulin molecule. | Proc Natl Acad Sci U S A | 1969 | https://conductscience.org/library/papers/5257969 | PubMed |
| 10 | 5,358,347 | Immunoglobulin peptide with complement fixing activity. | Nature | 1969 | https://conductscience.org/library/papers/5358347 | PubMed |
| 11 | 4,991,411 | Formation of three-dimensional structure in proteins. I. Rapid nonenzymic reactivation of reduced lysozyme. | Biochemistry | 1970 | https://conductscience.org/library/papers/4991411 | PubMed |
| 12 | 5,289,387 | Folding of polypeptide chains in proteins: a proposed mechanism for folding. | Proc Natl Acad Sci U S A | 1971 | https://conductscience.org/library/papers/5289387 | PubMed |
| 13 | 14,338,230 | RECOVERY OF SPECIFIC ACTIVITY AFTER COMPLETE UNFOLDING AND REDUCTION OF AN ANTIBODY FRAGMENT. | Proc Natl Acad Sci U S A | 1965 | https://conductscience.org/library/papers/14338230 | PubMed |
| 14 | 4,945,437 | The reaction of monomeric and aggregated immunoglobulins with C1. | Immunochemistry | 1971 | https://conductscience.org/library/papers/4945437 | PubMed |
| 15 | 4,581,224 | Acquisition of three-dimensional structure of proteins. | Annu Rev Biochem | 1973 | https://conductscience.org/library/papers/4581224 | PubMed |
| 16 | 4,857,587 | Amino acid sequence of a murine immunoglobulin fragment that possesses complement fixing activity. | Biochemistry | 1974 | https://conductscience.org/library/papers/4857587 | PubMed |
| 17 | 4,132,700 | Complement fixing and macrophage opsonizing activities associated with beta2 microglobulin. | Immunol Commun | 1974 | https://conductscience.org/library/papers/4132700 | PubMed |
| 18 | 4,099,771 | Molecular size and conformation of immunoglobulins. | Adv Immunol | 1970 | https://conductscience.org/library/papers/4099771 | PubMed |
| 19 | 4,351,801 | Nucleation, rapid folding, and globular intrachain regions in proteins. | Proc Natl Acad Sci U S A | 1973 | https://conductscience.org/library/papers/4351801 | PubMed |
| 20 | 4,184,996 | The antibody problem. | Annu Rev Biochem | 1969 | https://conductscience.org/library/papers/4184996 | PubMed |
Cited by15
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 58 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 35,613,051 | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. | Proc Natl Acad Sci U S A | 2022 | https://conductscience.org/library/papers/35613051 | PubMed |
| 34,639,093 | Global Proteotoxicity Caused by Human β2 Microglobulin Variants Impairs the Unfolded Protein Response in C. elegans. | Int J Mol Sci | 2021 | https://conductscience.org/library/papers/34639093 | PubMed |
| 32,661,194 | The role of the IT-state in D76N β2-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander? | J Biol Chem | 2020 | https://conductscience.org/library/papers/32661194 | PubMed |
| 28,879,061 | A practical guide to build de-novo assemblies for single tissues of non-model organisms: the example of a Neotropical frog. | PeerJ | 2017 | https://conductscience.org/library/papers/28879061 | PubMed |
| 28,298,446 | Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation. | J Biol Chem | 2017 | https://conductscience.org/library/papers/28298446 | PubMed |
| 23,329,840 | Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors. | J Biol Chem | 2013 | https://conductscience.org/library/papers/23329840 | PubMed |
| 20,377,236 | Strategy for degradomic-peptidomic analysis of human blood plasma. | J Proteome Res | 2010 | https://conductscience.org/library/papers/20377236 | PubMed |
| 11,514,668 | Role of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitro. | Protein Sci | 2001 | https://conductscience.org/library/papers/11514668 | PubMed |
| 10,850,793 | Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation. | Protein Sci | 2000 | https://conductscience.org/library/papers/10850793 | PubMed |
| 2,928,336 | Comparison of the secondary structures of human class I and class II major histocompatibility complex antigens by Fourier transform infrared and circular dichroism spectroscopy. | Proc Natl Acad Sci U S A | 1989 | https://conductscience.org/library/papers/2928336 | PubMed |
| 1,649,598 | Structural modifications of human beta 2 microglobulin treated with oxygen-derived radicals. | Biochem J | 1991 | https://conductscience.org/library/papers/1649598 | PubMed |
| 932,203 | A comparative analysis of the C1-binding ability of fragments derived from complement-fixing and noncomplement-fixing IgM proteins. | J Clin Invest | 1976 | https://conductscience.org/library/papers/932203 | PubMed |
| 825,451 | The importance of quaternary structure in the expression of the C1-binding site of IgM. | Immunology | 1976 | https://conductscience.org/library/papers/825451 | PubMed |
| 417,020 | Studies on the structural and biological functions of the Cmu4 domains of IgM. | Immunology | 1978 | https://conductscience.org/library/papers/417020 | PubMed |
| 91,170 | Heavy chain of HLA-A and HLA-B antigens is conformationally labile: a possible role for beta 2-microglobulin. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/91170 | PubMed |
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| HLA-G | 3,135 | PubTator's text mining | https://conductscience.org/library/genes/3135 |
Source NCBI Gene
Data dates
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
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- Drugs
- Data
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- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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