Paper91170
Heavy chain of HLA-A and HLA-B antigens is conformationally labile: a possible role for beta 2-microglobulin.
Lancet D and 2 others. Proc Natl Acad Sci U S A, 1979. Cited by 151 papers, by iCite.
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ConductScience Library. Heavy chain of HLA-A and HLA-B antigens is conformationally labile: a possible role for beta 2-microglobulin. Papers, record 91170. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/91170
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics9
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Beta-Globulins | Major topic |
| HLA Antigens | Major topic |
| beta 2-Microglobulin | Major topic |
| Epitopes | |
| Macromolecular Substances | |
| Peptide Fragments | |
| Protein Conformation | |
| Protein Denaturation | |
| Spectrophotometry, Ultraviolet |
Source PubMed
References23
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,055,432 | Evolutionary relationship between immunoglobulins and transplantation antigens. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1055432 | PubMed |
| 2 | 1,141,219 | Purification of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. | J Biol Chem | 1975 | https://conductscience.org/library/papers/1141219 | PubMed |
| 3 | 287,067 | Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/287067 | PubMed |
| 4 | 330,091 | Structure of HL-A A and B antigens isolated from cultured human lymphocytes. | Cold Spring Harb Symp Quant Biol | 1977 | https://conductscience.org/library/papers/330091 | PubMed |
| 5 | 363,227 | Evolution and function of the HLA system. | Br Med Bull | 1978 | https://conductscience.org/library/papers/363227 | PubMed |
| 6 | 371,676 | Fragmentation of the human transplantation antigen heavy chain by limited proteolysis, acid cleavage, and cyanogen bromide treatment. | Biochemistry | 1979 | https://conductscience.org/library/papers/371676 | PubMed |
| 7 | 396,105 | Isolation and structure of human histocompatibility (HLA) antigens. | Contemp Top Mol Immunol | 1977 | https://conductscience.org/library/papers/396105 | PubMed |
| 8 | 410,030 | Further structural studies of the heavy chain of HLA antigens and its similarity to immunoglobulins. | Proc Natl Acad Sci U S A | 1977 | https://conductscience.org/library/papers/410030 | PubMed |
| 9 | 4,124,595 | The genetic control of immunoglobulin synthesis. | Annu Rev Genet | 1972 | https://conductscience.org/library/papers/4124595 | PubMed |
| 10 | 4,139,785 | The immunoglobulin-like structure of human histocompatibility antigens. | Transplant Rev | 1974 | https://conductscience.org/library/papers/4139785 | PubMed |
| 11 | 4,175,239 | Isolation and properties of a low molecular weight beta-2-globulin occurring in human biological fluids. | J Biol Chem | 1968 | https://conductscience.org/library/papers/4175239 | PubMed |
| 12 | 444,449 | Chemical, physical-chemical, and immunological properties of papain-solubilized human transplatation antigens. | Biochemistry | 1979 | https://conductscience.org/library/papers/444449 | PubMed |
| 13 | 447,367 | Further structural analysis of the murine H-2Kb glycoprotein using radiochemical methodology. | Mol Immunol | 1979 | https://conductscience.org/library/papers/447367 | PubMed |
| 14 | 4,558,655 | 2 -Microglobulin--a free immunoglobulin domain. | Proc Natl Acad Sci U S A | 1972 | https://conductscience.org/library/papers/4558655 | PubMed |
| 15 | 465,472 | Folding pathways of immunoglobulin domains. The folding kinetics of the Cgamma3 domain of human IgG1. | Biochemistry | 1979 | https://conductscience.org/library/papers/465472 | PubMed |
| 16 | 47,633 | The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/47633 | PubMed |
| 17 | 4,830,825 | Physical-chemical properties of beta 2-microglobulin. | Immunochemistry | 1974 | https://conductscience.org/library/papers/4830825 | PubMed |
| 18 | 5,346,390 | Computed circular dichroism spectra for the evaluation of protein conformation. | Biochemistry | 1969 | https://conductscience.org/library/papers/5346390 | PubMed |
| 19 | 5,659,649 | Transplantation antigens from human spleens. | Nature | 1968 | https://conductscience.org/library/papers/5659649 | PubMed |
| 20 | 60,339 | Rapid purification of detergent-solubilized HLA antigen by affinity chromatography employing anti-beta2-microglobulin serum. | J Biol Chem | 1976 | https://conductscience.org/library/papers/60339 | PubMed |
Cited by48
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 151 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 37,092,447 | Antibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment. | Antibodies (Basel) | 2023 | https://conductscience.org/library/papers/37092447 | PubMed |
| 36,134,954 | Role of HLA-I Structural Variants and the Polyreactive Antibodies They Generate in Immune Homeostasis. | Antibodies (Basel) | 2022 | https://conductscience.org/library/papers/36134954 | PubMed |
| 35,214,796 | Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines. | Vaccines (Basel) | 2022 | https://conductscience.org/library/papers/35214796 | PubMed |
| 32,438,322 | The Mechanism of β2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. | iScience | 2020 | https://conductscience.org/library/papers/32438322 | PubMed |
| 26,634,302 | CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. | Blood | 2016 | https://conductscience.org/library/papers/26634302 | PubMed |
| 20,444,690 | Crystal structure of a bony fish beta2-microglobulin: insights into the evolutionary origin of immunoglobulin superfamily constant molecules. | J Biol Chem | 2010 | https://conductscience.org/library/papers/20444690 | PubMed |
| 18,323,608 | Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta2-microglobulin. | Acta Crystallogr Sect F Struct Biol Cryst Commun | 2008 | https://conductscience.org/library/papers/18323608 | PubMed |
| 9,420,246 | Characterization of a murine cytomegalovirus class I major histocompatibility complex (MHC) homolog: comparison to MHC molecules and to the human cytomegalovirus MHC homolog. | J Virol | 1998 | https://conductscience.org/library/papers/9420246 | PubMed |
| 9,114,041 | Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog. | Proc Natl Acad Sci U S A | 1997 | https://conductscience.org/library/papers/9114041 | PubMed |
| 9,104,809 | The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8. | J Exp Med | 1997 | https://conductscience.org/library/papers/9104809 | PubMed |
| 8,069,222 | Monte Carlo study of the effect of beta 2-microglobulin on the binding cleft of the HLA-A2 complex. | Protein Sci | 1994 | https://conductscience.org/library/papers/8069222 | PubMed |
| 7,688,348 | Assembly-dependent expression of antigenic epitopes by beta 2-microglobulin(b). | Immunogenetics | 1993 | https://conductscience.org/library/papers/7688348 | PubMed |
| 7,519,239 | Downregulation of peptide transporter genes in cell lines transformed with the highly oncogenic adenovirus 12. | J Exp Med | 1994 | https://conductscience.org/library/papers/7519239 | PubMed |
| 7,005,076 | Phenotypic conversion of human erythrocytes by H-Y antigen. | Hum Genet | 1980 | https://conductscience.org/library/papers/7005076 | PubMed |
| 6,571,999 | Anti-HLA antibodies of predetermined specificity: a chemically synthesized peptide induces antibodies specific for HLA-A,B heavy chain. | Proc Natl Acad Sci U S A | 1983 | https://conductscience.org/library/papers/6571999 | PubMed |
| 6,546,418 | A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens. | Nucleic Acids Res | 1984 | https://conductscience.org/library/papers/6546418 | PubMed |
| 6,319,431 | Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells. | J Cell Biol | 1984 | https://conductscience.org/library/papers/6319431 | PubMed |
| 6,199,195 | Endocytosis of HLA and H-2 molecules on transformed murine cells measured by fluorescence dequenching of liposome-encapsulated carboxyfluorescein. | EMBO J | 1983 | https://conductscience.org/library/papers/6199195 | PubMed |
| 6,187,676 | Genetics of beta-2 microglobulin in the mouse. | Immunogenetics | 1983 | https://conductscience.org/library/papers/6187676 | PubMed |
| 6,184,441 | HLA-A2 mutants immunoselected in vitro. Definition of residues contributing to an HLA-A2-specific serological determinant. | J Exp Med | 1983 | https://conductscience.org/library/papers/6184441 | PubMed |
Genes4
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| B2M | 567 | PubTator's text mining | https://conductscience.org/library/genes/567 | NCBI Gene |
| HLA-A | 3,105 | PubTator's text mining | https://conductscience.org/library/genes/3105 | NCBI Gene |
| HLA-B | 3,106 | PubTator's text mining | https://conductscience.org/library/genes/3106 | NCBI Gene |
| HLA-G | 3,135 | PubTator's text mining | https://conductscience.org/library/genes/3135 | NCBI Gene |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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